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A sustainable business model based on innovation and ... - Roche

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Rheumatoid Arthritis: Not all patients resp<strong>on</strong>d to<br />

current therapy<br />

Gold st<strong>and</strong>ard therapy<br />

anti-TNF + MTX<br />

% ACR70 Resp<strong>on</strong>ders<br />

Unmet Medical Need<br />

Only 1 of 3 patients receives<br />

significant benefit<br />

anti-TNF + MTX<br />

anti-TNF al<strong>on</strong>e<br />

ACR 7070 Improvement in:<br />

MTX al<strong>on</strong>e<br />

Disease activity – patient<br />

Disease activity – physician<br />

Patient assessment of Pain<br />

Physical disability<br />

Acute phase reactants – CRP,ESR<br />

27

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