Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

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Roche in autoimmune disorders Roche is well placed to address high unmet need and capitalize from large growth opportunity • Innovative pipeline with 2 first-in-class RA drugs in launch / pre-launch • Large investment in development program (second only to oncology) • Scientific and commercial collaboration with co-marketing partners Genentech and Chugai as well as other 3rd parties • Strong corporate commitment to build up Autoimmune franchise – RA – MS – Lupus – Vasculitis Roche poised to become a leader in Autoimmune Diseases 72
Q & A 73
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Roche Analyst Meeting EULAR 2007 Ba
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Introduction Dr. Karl Mahler Head o
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Roche’s key therapeutic areas Cur
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RA: A very concentrated market 6.00
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Increased penetration of biologics
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Actemra: The OPTION trial results P
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Elevated IL-6 plays central role in
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The OPTION study TOcilizumab Pivota
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Demographics Intent-to-treat popula
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Results: Efficacy and safety 20
Page 22 and 23: Rapid onset of action with tocilizu
Page 24 and 25: Tocilizumab induces rapid CRP norma
Page 26 and 27: Most frequently reported AEs Incide
Page 28 and 29: Adverse events Consistent with thos
Page 30 and 31: MabThera: Longer-term repeat treatm
Page 32 and 33: Rituximab selectively targets CD20-
Page 34 and 35: Rituximab: Advancing in RA Initial
Page 36 and 37: Inhibition of radiographic progress
Page 38 and 39: Efficacy: Repeat treatment courses
Page 40 and 41: Patient exposure to repeat courses
Page 42 and 43: ACR scores are sustained Repeated c
Page 44 and 45: Consistent time intervals between t
Page 46 and 47: More than 2400 patient-years As of
Page 48 and 49: No increase in infection rates with
Page 50 and 51: IgM RF levels by treatment course o
Page 52 and 53: Rates of serious infection Similar
Page 54 and 55: Roche’s franchise in autoimmune d
Page 56 and 57: Overview of autoimmune disorders IN
Page 58 and 59: Not all patients respond to current
Page 60 and 61: Major players are active in this ar
Page 62 and 63: Actemra Potential to become a signi
Page 64 and 65: Ocrelizumab in autoimmune diseases
Page 66 and 67: Multiple sclerosis An emerging ther
Page 68 and 69: Prevalence of MS in Europe ~260,000
Page 70 and 71: Development hurdles & treatment cha
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Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

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