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Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

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Major players are active in this area…<br />

…Yet opportunities remain for novel therapies<br />

Phase I/II<br />

Denosumab<br />

Amgen<br />

Ocrelizumab<br />

<strong>Roche</strong><br />

Orals<br />

e.g. p38<br />

HuMax 20<br />

GenMab<br />

Belimumab<br />

HGS/CAT/GSK<br />

Tru015<br />

Trubion/Wyeth<br />

Phase III<br />

Actemra<br />

<strong>Roche</strong><br />

Cimzia<br />

Celltech/UCB<br />

Golimumab<br />

J&J<br />

Launched<br />

Enbrel<br />

Amgen<br />

Remicade<br />

J&J<br />

Humira<br />

Abbott<br />

MabThera<br />

<strong>Roche</strong><br />

Orencia<br />

BMS<br />

1998 1999 2000 2001 2002 2003 2004 2005<br />

2006<br />

2008 and later<br />

Anti-TNF Other MoA Costimulation modulator B-Cell Targeted Therapy <strong>Roche</strong><br />

60

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