Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

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Overview of autoimmune disorders INDICATION PRIMARY PATHOLOGY HIGH NEED? PREVALENCE PATIENTS DISEASE PROGRESSION Rheumatoid Arthritis Joint/bone degeneration Yes 1% global +60 mln WW Mild, moderate, severe Multiple Sclerosis Destruction of CNS myelin Yes
RA patient cascade Top 5 European countries 1'800'000 1'600'000 1'400'000 1% population > 35 years Patients with GP Patients with Rheumatologist Patients (Actual) 1'200'000 1'000'000 800'000 600'000 400'000 200'000 0 30-40% inadequate response DMARD-<strong>IR</strong> TNF-<strong>IR</strong> 80K 60K Prevalence RA Diag/Trt All DMARDs 1st Biologic ≥2nd Biologic Source: Decision Resources 57
Page 2 and 3:
Roche Analyst Meeting EULAR 2007 Ba
Page 4 and 5:
Introduction Dr. Karl Mahler Head o
Page 6 and 7: Roche’s key therapeutic areas Cur
Page 8 and 9: RA: A very concentrated market 6.00
Page 10 and 11: Increased penetration of biologics
Page 12 and 13: Actemra: The OPTION trial results P
Page 14 and 15: Elevated IL-6 plays central role in
Page 16 and 17: The OPTION study TOcilizumab Pivota
Page 18 and 19: Demographics Intent-to-treat popula
Page 20 and 21: Results: Efficacy and safety 20
Page 22 and 23: Rapid onset of action with tocilizu
Page 24 and 25: Tocilizumab induces rapid CRP norma
Page 26 and 27: Most frequently reported AEs Incide
Page 28 and 29: Adverse events Consistent with thos
Page 30 and 31: MabThera: Longer-term repeat treatm
Page 32 and 33: Rituximab selectively targets CD20-
Page 34 and 35: Rituximab: Advancing in RA Initial
Page 36 and 37: Inhibition of radiographic progress
Page 38 and 39: Efficacy: Repeat treatment courses
Page 40 and 41: Patient exposure to repeat courses
Page 42 and 43: ACR scores are sustained Repeated c
Page 44 and 45: Consistent time intervals between t
Page 46 and 47: More than 2400 patient-years As of
Page 48 and 49: No increase in infection rates with
Page 50 and 51: IgM RF levels by treatment course o
Page 52 and 53: Rates of serious infection Similar
Page 54 and 55: Roche’s franchise in autoimmune d
Page 58 and 59: Not all patients respond to current
Page 60 and 61: Major players are active in this ar
Page 62 and 63: Actemra Potential to become a signi
Page 64 and 65: Ocrelizumab in autoimmune diseases
Page 66 and 67: Multiple sclerosis An emerging ther
Page 68 and 69: Prevalence of MS in Europe ~260,000
Page 70 and 71: Development hurdles & treatment cha
Page 72 and 73: Roche in autoimmune disorders Roche
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Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

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