Microsoft PowerPoint - Roche IR Event EULAR Final.ppt

Inhibition of radiographic progression
Even in patients who do not achieve an ACR20 response (week 24)
Mean change at Week 56
3.0
2.5
2.0
1.5
1.0
0.5
p=0.004
2.82
0.66
p=0.0076
Placebo (n=104)
p=0.0056
1.72
1.1
0.33 0.33
RTX (n=87)
0.0
Total Genant-modified Joint space narrowing Erosion score
Sharp score
Primary analysis: Radiographs within time window, linear extrapolation from Week 24 for missing values
Keystone et al. EULAR 2007
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