Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
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Inhibition of radiographic progression<br />
First evidence in patients with inadequate response to TNF inhibitors<br />
Mean change at Week 56<br />
2.5<br />
2.0<br />
1.5<br />
1.0<br />
0.5<br />
0.0<br />
p=0.0046<br />
2.31<br />
1<br />
Total Genant-modified<br />
Sharp score<br />
p=0.0006<br />
0.99<br />
0.41<br />
Joint space narrowing<br />
Placebo (n=184) RTX (n=273)<br />
p=0.0114<br />
1.32<br />
0.59<br />
Erosion score<br />
Primary analysis: Radiographs within time window, linear extrapolation from Week 24 for missing values<br />
Keystone et al. <strong>EULAR</strong> 2007 (Abstract No. SAT0011)<br />
36