Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
Microsoft PowerPoint - Roche IR Event EULAR Final.ppt
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IL-6 contributes to chronic inflammation in RA<br />
Monocytes/<br />
macrophages<br />
T cell activation<br />
Endothelial cells<br />
IL-6<br />
Mesenchymal cells,<br />
fibroblasts/<br />
synoviocytes<br />
Hepatocytes<br />
Maturation of<br />
megakaryocytes<br />
B cells<br />
Acute-phase proteins<br />
hepcidin, CRP<br />
Osteoclast activation<br />
Bone resorption<br />
Thrombocytosis<br />
Auto-antibodies (RF)<br />
Hyper γ-globulinaemia<br />
Firestein GS. Nature 2003;423:356–361; Smolen JS and Steiner G. Nat Rev Drug Disc 2003;2:473–488<br />
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