Kredex (carvedilol) - Product Information (PI) - Roche Australia
Kredex (carvedilol) - Product Information (PI) - Roche Australia
Kredex (carvedilol) - Product Information (PI) - Roche Australia
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Cardiovascular System: Fluid overload, and postural hypotension.<br />
Central and Peripheral Nervous System: Hyperaesthesia and vertigo.<br />
Gastrointestinal: Melaena and periodontitis.<br />
Liver and Biliary System: AST and ALT increased.<br />
Haematology: Purpura, prothrombin decreased.<br />
Metabolic and Nutritional: Hyperuricaemia, hypoglycaemia, hyponatraemia, increased alkaline<br />
phosphatase, glycosuria.<br />
Psychiatric: Somnolence.<br />
Reproductive, male: Impotence.<br />
Urinary System: Abnormal renal function, albuminuria.<br />
Less Common >0.1% to ≤1%<br />
The following adverse events were reported as possibly or probably related in worldwide open or<br />
controlled trials with KREDEX in patients with hypertension or congestive heart failure.<br />
Cardiovascular: Peripheral ischaemia, tachycardia.<br />
Central and Peripheral Nervous System: Hypokinesia.<br />
Gastrointestinal: Hyperbilirubinaemia, increased hepatic enzymes (0.2% of hypertension patients<br />
and 0.4% of congestive heart failure patients were discontinued from therapy because of increases<br />
in hepatic enzymes; see PRECAUTIONS, Hepatic Injury).<br />
General: Substernal chest pain, oedema.<br />
Psychiatric: Sleep disorder, aggravated depression, impaired concentration, abnormal thinking,<br />
paranoia, emotional lability.<br />
Respiratory System: Asthma (see CONTRAINDICATIONS).<br />
Reproductive, Male: decreased libido.<br />
Skin and Appendages: Pruritus, rash erythematous, rash maculopapular, rash psoriaform,<br />
photosensitivity reaction.<br />
Special Senses: Tinnitus.<br />
Urinary System: Micturition frequency.<br />
<strong>Kredex</strong> ® <strong>PI</strong> 110720<br />
CDS 5.0 18 of 24