to view our brochure - Research Institute for Fragrance Materials
to view our brochure - Research Institute for Fragrance Materials
to view our brochure - Research Institute for Fragrance Materials
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RIFM’S VISION<br />
To be the international scientific authority<br />
<strong>for</strong> the safe use of fragrance materials<br />
MISSION<br />
■ Engage in research and evaluation<br />
of fragrance materials through an<br />
independent expert panel<br />
■ Determine safety in use<br />
■ Gather, analyze and publish<br />
scientific in<strong>for</strong>mation<br />
■ Distribute scientific data and safety<br />
assessment judgements <strong>to</strong> RIFM<br />
members, industry associations and<br />
other interested parties<br />
■<br />
Maintain an active dialogue with<br />
official international agencies<br />
Transparent<br />
Science<br />
Supports<br />
Brand<br />
Trust<br />
RIFM AND IFRA TOGETHER PROTECT THE<br />
CONSUMER AND THE ENVIRONMENT<br />
RIFM and the International <strong>Fragrance</strong> Association (IFRA)<br />
are two global organizations that work <strong>to</strong>gether <strong>for</strong><br />
fragrance ingredient safety. IFRA Standards are based on<br />
RIFM peer-re<strong>view</strong>ed science, validated by independent<br />
experts, and determine how fragrance ingredients can<br />
safely interact with humans and the environment.<br />
The RIFM/IFRA relationship allows <strong>for</strong> efficient<br />
coordination of data from the science arena <strong>to</strong> action<br />
(IFRA Standard) and the advocacy needs of the fragrance<br />
industry. This special relationship between RIFM and IFRA<br />
facilitates communication of in<strong>for</strong>med scientific data on<br />
the safe use of fragrance raw materials throughout the<br />
global fragrance industry and <strong>to</strong> official agencies and<br />
other interested parties around the world.<br />
The <strong>Research</strong> <strong>Institute</strong> <strong>for</strong> <strong>Fragrance</strong> <strong>Materials</strong><br />
(RIFM), founded in 1966, is the international<br />
scientific authority <strong>for</strong> the safe use of fragrance<br />
materials. RIFM generates, evaluates and distributes<br />
scientific data on the safety assessment of fragrance<br />
raw materials found in fine fragrances, and other<br />
personal and household care products. Through<br />
extensive research, testing and constant moni<strong>to</strong>ring<br />
of pertinent scientific literature, RIFM per<strong>for</strong>ms<br />
fragrance ingredient safety evaluations. All resulting<br />
<strong>to</strong>xicological, environmental data, physical-chemical<br />
properties, literature and in<strong>for</strong>mation is maintained<br />
in the most comprehensive Database, worldwide, of<br />
known fragrance and flavor materials.<br />
RIFM Science is the sustainable, cost-effective<br />
solution <strong>for</strong> fragrance material safety evaluation.<br />
Shared safety research and testing expenses<br />
eliminate unnecessary and duplicate testing and<br />
provide uni<strong>for</strong>m interpretation of test results.<br />
<strong>Research</strong> <strong>Institute</strong> <strong>for</strong><br />
<strong>Fragrance</strong> <strong>Materials</strong><br />
The International Authority <strong>for</strong><br />
the Safe Use of <strong>Fragrance</strong> <strong>Materials</strong><br />
RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS, INC.<br />
50 Tice Boulevard<br />
Woodcliff Lake, NJ 07677 USA<br />
p : 201.689.8089<br />
f : 201.689.8090<br />
email: rifm@rifm.org<br />
www.rifm.org
The RIFM Database: The most comprehensive database<br />
of fragrance and flavor materials in the world.<br />
RIFM SCIENCE<br />
RIFM’s extensive scientific program provides the<br />
most complete evaluations on the safe use of<br />
fragrance raw materials and includes Human<br />
Health, Respira<strong>to</strong>ry, and Environmental endpoints.<br />
All data collected by RIFM <strong>for</strong> their evaluations are<br />
housed in the RIFM Database.<br />
The Quantitative Risk Assessment (QRA)<br />
determines safe use levels of fragrance ingredients<br />
in a variety of consumer product types <strong>to</strong> prevent<br />
dermal sensitization.<br />
The EDEN Project – the European Derma<strong>to</strong>-<br />
Epidemiology Network (EDEN) under the guidance<br />
of the Expert Panel designed an original study <strong>to</strong><br />
determine the prevalence of contact allergy in the<br />
general population.<br />
Aggregate Exposure Model – assesses<br />
aggregated consumer exposure <strong>to</strong> fragrance<br />
ingredients from various products in use daily by<br />
the typical consumer.<br />
RIFM is developing alternative methods <strong>for</strong> testing<br />
fragrance materials <strong>for</strong> Human Health, Respira<strong>to</strong>ry<br />
and Environmental endpoints. A number of models<br />
are available <strong>to</strong> RIFM Database subscribers.<br />
RIFM Respira<strong>to</strong>ry Models<br />
▲ 2-Box Indoor Air Dispersion Model assesses<br />
inhalation exposure.<br />
▲ Computational Fluid Dynamics (CFD) and<br />
Multiple Path Particle Deposition (MPPD)<br />
are in silico predictive dosimetry profilers that<br />
locate and quantify materials deposited in the<br />
respira<strong>to</strong>ry tract <strong>to</strong> assess potential biological<br />
effects following inhalation exposure.<br />
AN EXPERT PANEL REVIEWS<br />
RIFM SCIENCE<br />
All of RIFM's scientific findings are re<strong>view</strong>ed by an<br />
Expert Panel – internationally renowned<br />
derma<strong>to</strong>logists, pathologists, <strong>to</strong>xicologists,<br />
respira<strong>to</strong>ry, reproduction and environmental<br />
scientists. And, additional expertise is provided by<br />
adjunct groups when needed. The Expert Panel<br />
evaluates the safety of fragrance ingredients under<br />
conditions of intended use and their independent<br />
evaluations are published in peer-re<strong>view</strong>ed<br />
scientific j<strong>our</strong>nals. The decisions of the Expert Panel<br />
regarding restrictions of fragrance ingredient use<br />
are also published as an IFRA Standard, available<br />
<strong>to</strong> the public at www.ifraorg.org.<br />
RIFM’s well-documented conclusions from<br />
comprehensive analysis translate <strong>to</strong> enhanced<br />
product management – resulting in safer<br />
and more life-enriching products <strong>for</strong> the<br />
consumer.<br />
The Member Advantage<br />
THE RIFM DATABASE<br />
Through extensive research, testing and constant<br />
moni<strong>to</strong>ring of pertinent scientific literature, RIFM maintains<br />
the most comprehensive Database, worldwide, of<br />
<strong>to</strong>xicological, eco-<strong>to</strong>xicological data and physical-chemical<br />
properties associated with known fragrance and flavor<br />
materials. The RIFM Database covers more than 5,700<br />
substances, categorized by CAS numbers, and contains<br />
related synonyms, regula<strong>to</strong>ry, inven<strong>to</strong>ry, occupational and<br />
industry labeling in<strong>for</strong>mation.<br />
Access <strong>to</strong> the most comprehensive database of<br />
fragrance and flavor material available 24 h<strong>our</strong>s a<br />
day, 7 days a week.<br />
Membership in RIFM is open <strong>to</strong> all companies<br />
that manufacture, sell, distribute or engage in business<br />
related <strong>to</strong> the fragrance industry <strong>for</strong> at least one year.<br />
View RIFM’s Global Member List at<br />
www.rifm.org<br />
Membership in RIFM expands y<strong>our</strong> network <strong>to</strong> include<br />
fragrance industry leaders, RIFM, IFRA and fragrance<br />
industry scientists and other experts in the scientific and<br />
academic communities.<br />
RIFM Members<br />
▲ Receive discounted subscriptions <strong>to</strong> the RIFM Database<br />
▲ Receive free or discounted Letters of Access (LoAs) <strong>to</strong><br />
RIFM funded studies used <strong>for</strong> material registration<br />
▲ Receive free or discounted RIFM publications<br />
▲ Receive free or discounted registration <strong>for</strong> RIFM<br />
educational offerings—in-person or webinar<br />
▲ Rely on the expertise of RIFM staff scientists <strong>to</strong> address<br />
technical needs and questions<br />
▲ May request materials research and re<strong>view</strong> by the<br />
independent Expert Panel<br />
Open Communication based on real science. The world's leading authorities on<br />
<strong>Fragrance</strong> Safety protect the consumer by setting the highest standards <strong>for</strong> fragrance<br />
use in personal and home care products.