2011 RIFM Annual Report - Research Institute for Fragrance Materials

Research Institute for Fragrance Materials, Inc.
The International Scientific Authority for the Safe Use of Fragrance Materials
21 st Century
Pathways and People
2011 Annual Report

2 21st Century Pathways and People www.rifm.org rifm@rifm.org

VISION
To be the International Scientific Authority for the Safe Use of Fragrance Materials
MISSION
• Engage in research and evaluation of fragrance materials through an
independent Expert Panel
• Determine safety in use
• Gather, analyze and publish scientific information
• Distribute scientific data and safety assessment judgments to
RIFM members, industry associations and other interested parties
• Maintain an active dialogue with official international agencies
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2011 Annual Report
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Table of Contents
21st Century Pathways and People
2011 Annual Report
Vision - Mission 1
Letter From the RIFM Board Chair 4
Letter From RIFM’s President 6
RIFM’s Board Of Directors 8
RIFM’s 45th Annual Meeting 9
News From The Expert Panel 10
Human Health Science 14
Environmental Science 20
Respiratory Science 24
The RIFM Database 26
RIFM Communications 28
Member Services 29
The RIFM Staff 30
RIFM’s Member List 32

Message From the RIFM Board Chair
It has been an honor and a privilege to have served you as Chair of
RIFM’s Board of Directors this past year. I would like to update you on the
state of RIFM and offer a glimpse of the challenges facing us.
One of the primary responsibilities of the Board is governance. RIFM
is in excellent shape financially thanks to the support, even in these
difficult economic times, of its member companies. With a recent clean
opinion from its auditors, RIFM fulfills its commitment, through the
interaction and guidance of the Expert Panel, to ensure the integrity of
the science produced at RIFM and to maintain the level of transparency
its membership and the global community has come to expect. The
safety program is, after all, its whole reason for being.
RIFM continues to publish research results in the open, peer reviewed
literature. In the period between 2007 and 2010, RIFM had three of the
most cited papers in the leading Journal, Food and Chemical Toxicology.
RIFM works closely with Industry to identify emerging issues for proactive research. New programs in respiratory
science and recent alternative methodologies for fragrance ingredient risk assessment are but a few of the
projects underway. This authority underlies RIFM’s reputation as the place to go for the most comprehensive
and current research on fragrance safety. The pages of this annual report are testament to the progress in
excellent science RIFM carries forward from its 46 year history of sound scientific research.
Of course there are always challenges which come to us at an ever-increasing pace. Unfortunately, the
significant progress we have made is not fast enough for our critics. Going forward we will need to address
these criticisms head on. We have a dual need of even more urgency for our testing program, while ensuring
the thoroughness and credibility of the science itself.
There are approximately 2,700 fragrance materials used worldwide, with 1,700 of these ingredients used at

The exact cost for this ambitious program is still being determined but as you would expect, the price tag
will be substantial and we must all share the cost.
The IFRA Board – the fragrance companies that support a large part of RIFM’s and IFRA’s activities – has
agreed to begin such a program. It will be robust, and will allow RIFM staff to obtain the necessary data/
information for the Expert Panel to complete and publish its safety evaluations. It is intended that this new
effort also will communicate more directly with the public. The message: The fragrance industry is serious
about its responsibilities and will continue to ensure the safe enjoyment of fragrances by millions of
consumers around the world every day.
I would like to publicly acknowledge the RIFM staff, the many industry volunteers and RIFM’s member
companies who generously make their expert staff available for the benefit of the whole industry and
society.
I would also like to recognize the RIFM Board of Directors, and Executive Committee, who have been
so dedicated in their roles and committed to RIFM. The breadth of representation in our Board meeting
continues to result in a truly rich input that enables a very high quality discussion. I would like to thank
the Board for this engagement and their support of me in my role – it has certainly made my job easier.
Thank you.
Sean G. Traynor, Ph.D.
Chair, RIFM Board
President, Takasago International Corp. (USA)
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2011 Annual Report
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Letter From The President
Ladies and Gentlemen of the Membership,
RIFM’s 2011 performance is best reflected in some highlights from my
State of the Institute address, delivered at the 45th Annual Meeting of
the membership on November 3rd. The largest attendance in our history,
and the fact that we dedicated our program theme to Alternative
Methodology, stand in testament to our ongoing evolution.
• Our annual budget is approaching $10 million and provides testing,
research and technical expertise from the staff and Expert
Panel. In 2011, we closed the year at a board-approved slight
deficit. Operations costs reflected legal fees and software upgrades.
Science expenditures were influenced by technical workshops
and staff activity. Most of the deficit came from testing and
research to accelerate respiratory work and use level support.
• Our reserve fund is a healthy $3.5 million and will support future
accelerated testing, while a baseline will be maintained for extraordinary
situations.
• Total membership, currently at 77 companies (47 Active, 6 IFRA
Active, 5 Consumer Active, 16 Supporting, 2 Associate), has remained
very stable over the last decade despite industry consolidation
and global economic turmoil.
• Expert Panel activities continue to address priority ingredient issues, long term testing strategy and
publication of peer-reviewed scientific evaluations. Implementation of guidelines for tenure and rotation
provide for relevant expertise and new thinking. Next additions will include chemistry and reproduction
practitioners.
• RIFM peer-reviewed publications – individual test results, respiratory deposition modeling, environmental
group analyses and human health group summaries – continue to strengthen our scientific
credibility.
• Our postdoctoral training program is in its 4th successful year, having placed 3 well-educated and
further experienced individuals within member companies.
• Our business now is conducted through an online store, so members and other customers can have
access to our educational and technical events, and we can accept electronic payment.
• We have a social media presence and function in an international news arena. RIFM’s communications
on LinkedIn, Facebook and Twitter will continue to be an important source of information in an increasingly
connected world.
• A state-of-the-science epidemiology study will be reported in 2012 to finally address the true prevalence
of fragrance allergy in the general population.
• The first environmental group summary was published.
6 21st Century Pathways and People www.rifm.org rifm@rifm.org

• Our respiratory program has developed and published novel methods to accurately evaluate inhalation
exposure, related to important societal questions.
• All our scientific programs integrate predictive, alternative and traditional methodology to supplement
available data for a comprehensive safety evaluation.
• Our flavor and fragrance database continues to expand its safety data and regulatory content and
refine its usability, to provide unique member value and non-dues revenue through data sales for regulatory
compliance. Features include state-of-the-art server technology, off site backup and expanded
access.
The highest current priority is development and implementation of an accelerated program to ensure adequate
safety support of individual fragrance ingredients. This will involve a concerted effort, throughout the
supply chain, to assess what we know, and to create a systematic approach for filling needs through all applicable
methods. The greater challenge is to balance competing influences – to maintain the programmatic
inertia that exists, to continue research, to increase testing – using transparent processes consistent with the
goal of consumer protection.
Other accomplishments over the last 14 years have addressed not only the scientific needs of the organization,
but also the requirements of operating a global business. A few of these are: development of a Comprehensive
Research Plan with a 5-year outlook and use of a Strategic Advisory Group to vet priorities and
identify emerging issues; redesign of the Corporate logo and development of branding as the international
scientific authority for safe use of fragrance ingredients; initiation of a robust communication program with annual
reports, an updated website and use of press releases for widespread information sharing; self-analysis
of board governance practices, member services and company satisfaction; installation of association management
software to create administrative efficiencies; development of best practices for fulfillment of tax
requirements and fiduciary responsibilities; global recognition of RIFM staff professional expertise. Looking
back on the opportunities I have had for mentorship, the last point is particularly meaningful to me.
As I retire from my position as President in 2012, I want to express my gratitude to all those I have encountered
and with whom I have had the pleasure to work. There is a lot of passion in this industry, which should
serve it well in the future, as product life cycles mature, new markets develop and sustainable organizations
are created.
Best regards,
Ladd W. Smith, PhD, Dipl ABT, Fellow ATS, CAE
President
Research Institute for Fragrance Materials, Inc. (RIFM)
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2011 Annual Report
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The RIFM Board of Directors
Executive Committee
Sean G. Traynor, Ph.D. (Chair)
President
Takasago International Corp.
USA
Robert H. Bedoukian, Ph.D.
(Vice Chair)
President
Bedoukian Research, Inc.
David C. Shipman (Treasurer)
Group Vice President
Firmenich
Stephen Hicks (Secretary)
Director, R&D
The Procter & Gamble Company
Michael Carlos
President - Fragrance Division
Givaudan Corporation
Ladd W. Smith, Ph.D., Dipl.
ABT, Fellow ATS, CAE (Staff
Liaison)
President
RIFM
The RIFM Board meets 3 times per year and at this time
has two subcommittees, the RIFM Executive Committee
and the Strategic Advisory Group which works on strategic
governance to maximize the efficiency of RIFM’s
technical areas, Human Health, Respiratory, and Environmental
Sciences and the RIFM Technical Database.
The Board consists of 18 voting members representing
13 fragrance ingredient manufacturers and 5 consumer
product companies, all of which are RIFM Active
members. There are also 5 non-voting, liaison members
from the International Fragrance Association (IFRA), the
Japanese Flavor & Fragrance Manufacturers Association
(JFFMA), and the International Fragrance Association
North America (IFRANA).
Directors
George Daher, Ph.D.
V. P., Global Safety Assess. & Reg. Affairs
S.C. Johnson & Son, Inc.
Achim Daub
Global Pres. Scent & Care,
Exec. Board Symrise AG
Symrise AG
Rob J. M. Edelman
V. P., Global BU Fragrance Ingredients
International Flavors & Fragrances, Inc.
Isabelle Esser
Vice President
Deodorants R&D
Unilever
James Heinz
President & CEO
Bell Flavor and Fragrances, Inc.
Antoine Housset
Deputy CEO Corporate Affairs
Chanel SA
Peter N. Lombardo
President
Robertet, Inc.
Stephen R. Manheimer
Executive Vice President
Kerry Ingredients & Flavours, Inc.
Miguel Pena
Vice President, Aroma Chemicals
BASF SE
Richard C. Pisano, Sr.
Executive Chairman
Citrus & Allied Essences
Viny Srinivasan, Ph.D., Dipl. ABT
Asst. Vice P.resident
L’Oreal
Steve Tanner
President/CEO
Arylessence, Inc.
Non-Voting Liaison Members
Pierre Sivac, President
IFRA
Yoshinari Niimura
JFFMA
Jennifer Abril, Executive Director
Kim Bleimann, President
IFRANA
Kevin Renskers, Ph.D
IFRA Scientific Committee Chair
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RIFM’s 45th Annual Meeting
RIFM’s 45th Annual Meeting highlighted the development of technology for Alternative Methods of testing materials that
is taking place in the scientific community, the fragrance industry and at RIFM. The theme of the 2011 Annual Meeting
and Report, “21st Century Pathways and People,” was derived from the National Academy of Science publication, Toxicity
Testing in the 21st Century: A Vision and A Strategy which can be viewed from the National Academy Press website
at www.nap.edu.
The publication was a project of the National Research Council, whose members are drawn from the councils of the
National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of
the committee responsible for the report were chosen for their special competencies and with regard for appropriate
balance. The project was supported by the National Academy of Sciences and the U.S. Environmental Protection Agency.
RIFM was fortunate to have as speakers, two of the authors of Toxicity Testing in the 21st Century.
Daniel Krewski, MHA, MSc., PhD
Daniel Krewski, MHA, MSc., PhD., Scientific Director
of the McLaughlin Centre for Population Health Risk
Assessment at the University of Ottawa and Martin L.
Stephens, PhD., Vice President and Senior Research
Associate at Johns Hopkins University Center for
Alternatives to Animal Testing (CAAT). Both spoke
about different facets of 21st century shift in technology
from the animal model to the human model and
how it affects toxicity testing and human health risk
assessment and safety.
Martin L. Stephens, PhD.
Rounding out the speakers for the day was Jean-
Roch Meunier, PhD., International Director of the
Department of Predictive Biological Models and
Methods at L’Oreal who gave the industry presentation
on the development of an integrative approach
for toxicity testing.
Jean-Roch Meunier, PhD.
The Expo
This year RIFM expanded the annual meeting to include an exposition designed to allow RIFM staff to
demonstrate and inform meeting attendees about the alternative methods and models for fragrance
material risk assessment in progress at RIFM. The demos and all presentation from the RIFM 45th Annual Meeting are
available, for members, from the RIFM web site in the Member Events Archive
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2011 Annual Report
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Report From The Expert Panel
The Expert Panel continues its tenure/rotation schedule. The complete roster of scientists participating on the independent
panel is listed here. Other scientific experts, who participate as adjuncts, supplement the Expert Panel’s knowledge base.
Items at each panel meeting include Conflict of Interest declaration, human health and environmental group summaries
and fragrance material reviews, IFRA use level testing and Standards approval, priority materials resulting from PBT evaluations
and human health and environmental criteria documents and risk assessments, the Comprehensive Research Plan,
impact of REACH and systemic, dermal and environmental decision trees. The Expert Panel meets three times per year.
The Expert Panel
Dr. I. Glenn Sipes, PhD. (Chair)
Professor & Department Head
Department of Pharmacology,
College of Medicine
University of Arizona
Tucson, AZ USA
Prof. Donald V. Belsito, MD
Clinical Professor, Medicine
Department of Dermatology
Columbia University Medical Center
New York, NY USA
Dr. David R. Bickers, MD (Co-Chair)
Carl Truman Nelson Prof. & Chair
Department of Dermatology
Columbia University Medical Center
New York, NY USA
Prof. Magnus Bruze, MD - Professor
Department of Occupational &
Environmental Dermatology
Malmo University Hospital
Malmo, Sweden
Research Prof. Peter Calow, PhD
Science and Public Policy
Office of Research and Economic
Development
University of Nebraska
Lincoln, NE
Prof. Maria L. Z. Dagli, DVM, PhD.
Professor, Veterinary Pathologist
Department of Pathology
School of Veterinary Medicine and
Animal Science
University of Sao Paulo
Sao Paulo, Brazil
Prof. Dr. Wolfgang Dekant
Institut fuer Toxikologie
Universitaet Wuerzburg
Wuerzburg, Germany
Prof. Allison D. Fryer, PhD
Prof. of Pulmonary and Critical Care
Oregon Health & Science University
Portland, OR USA
Dr. Yoshiki Miyachi, MD, PhD
Professor & Chairman, Dermatology
Graduate School of Medicine
Kyoto University Hospital
Kyoto, Japan
Prof. Jean-Hilaire Saurat, MD
Professor & Chairman, Dermatology
Swiss Center for Applied Human
Toxicology
University of Geneva
Geneva, Switzerland
Reproduction Advisory Panel
Dr. Jochen Buschmann
Head of Reproductive Toxicology
Working Group
Fraunhofer Inst. of Toxicology and
Experimental Medicine
Hannover, Germany
Dr. Anthony Scialli
Consultant
Tetra Tech Sciences
Arlington, VA USA
Dr. Mineo Yasuda - Emeritus Professor
Hiroshima University
Sendai, Japan
Environmental Adjunct Group
Prof. Beate Escher
Deputy Director
National Research Centre for
Environmental Toxicology (Entox)
University of Queensland
Coopers Plains, Queensland Australia
Prof. Michael J. Whelan, Ph.D.
Sr. Lecturer in Environmental Science
Dept. of Natural Resources
Cranfield University
Bedfordshire, United Kingdom
Genetic Toxicity Adjunct Group
Experts from the Neuherberg Institute
for Toxicology,
Germany
via Dr. Helmut Greim
10 21st Century Pathways and People www.rifm.org rifm@rifm.org

The Expert Panel’s January meeting, held in
Miami, Florida included a presentation by Dr. Wolfgang
Dekant, University of Wurzburg, Germany, on some of
his academic work with the toxicokinetics of 4-MBC, a
material used in sunscreens. Dr. Dekant, a member of
the Scientific Committee on Health and Environmental
Risks (SCHER) committee in the EU, was invited
to join the panel as a standing member. Dr. Helmut
Greim rotated off the group, according to established
operating guidelines. Other guests included a journalism
student, Mr. Pierre Sivac, IFRA President, and Mr.
Michel Bongi, IFRA Board Chair.
Occupational Exposure
The Panel continued its discussion of relevant
occupational exposure, defined as the professional
use of fragrance in settings such as hospitals, beauty
salons and department stores. Evaluations of Finn and
Hilltop patch test chambers were planned, to resolve
false positive reactions seen in some phototoxicity assays.
Results and plans from the Data Analysis and
Priorities Group (DAPG) for accelerating the testing
program were reviewed.
Respiratory Program Reports
Respiratory Program reports detailed endpoints,
deposited dose, in the upper airways and lungs and
wall mass flux (tissue absorption) for a variety of materials
such as formaldehyde (control), acrolein (control)
and acetaldehyde, as part of the Dosimetry/Deposition
Computational Modeling Project. Corroboration
studies have been completed with d-limonene, α-hexyl
cinnamaldehyde, and isoeugenol showing little to no
effect following 14 days of inhalation exposure. An
alternative method in development that evaluates
cytokine profiling was shown to be successfully
feasible. Preliminary studies showed acceptable
cell viability, intact cell junctions, and consistent cellular
behavioral characteristics. Dendritic cell maturation,
needed for sensitization, was shown to be
independent of macrophage ratio and, as expected,
dependent on signaling from both macrophages and
epithelial cells. All 3 cell-types comprise the actual
air-exchange unit in the lungs. A joint RIFM/member
company proposal was submitted to the CEFIC Long
Range Initiative Program for Inhalation Toxicological
Threshold of Concern (TTC). The proposal was not
funded due to the greater experience of the Fraunhofer
Institute who ultimately received the award. RIFM
entered into a data sharing agreement with the
Fraunhofer Institute to continue active participation in
this project.
IFRA
IFRA business included actions on sensitization
data for p-methoxybenzaldehyde, cyclamen aldehyde,
vanillin, vanillin isobutyrate, alpha-butylcinnamaldehyde,
ortho-methoxycinnamaldehyde, 2-heptylidene
cyclopentan-1-one, 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one,
1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one,
2,6,6-trimethylcyclohex-1,3-dienyl
methanol and isoeugenol.
Reproduction Workshop
A reproduction toxicity workshop was held following
the Panel meeting, with invited guests
from the Expert Panel, the Reproduction Advisory
Group, the IFRA Scientific Committee and member
companies, as well as external experts.
Key points included:
• In vitro metabolism should use rat, rabbit and
human cells
• The current enhanced OECD 415 in vivo protocol
was further modified to a significant degree—as
a benchmark study for a material which would
support a structural group
• Dietary administration was selected, with the
desire for kinetic studies, skin absorption and
consideration of
microencapsulation
to avoid high/
bolus doses
• Hazard/toxicity
studies are preferred
vs. safety
studies, although
CMR and other
labeling issues
arise from studies
which show adverse
effects
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2011 Annual Report
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Report From The Expert Panel
In May 2011, the Expert Panel met in Brussels,
Belgium, following cancellation of the planned
trip to Tokyo due to the unfortunate natural events
which occurred there. DAPG status was reviewed,
notably the decision to retain responsibility for
functional ingredients, the content of the 11-endpoint
Safety Dossier and company interest in supporting
certain aroma chemicals. Occupational exposure was
defined as “professional consumer” use, such as hair
salons and similar consumer-oriented work spaces.
Data from one company’s survey of 300 hair salons
was reviewed.
EDEN
The EDEN epidemiology study was reported by
Dr. Thomas Diepgen, one of the principal investigators.
All people had been recruited for the 6
European clinics; 10,000 had been interviewed
and 2500 had been patch tested. Dr. Hans Merk
also presented his expertise on proteins and
metabolism, and the relevancy of understanding the
proper dose and route of administration, such as
the ability of a parent molecule to stimulate its own
activation. Dr. Matthias Vey, IFRA Scientific Director,
presented the results of an IFRA Scientific Committee
workshop on IFRA Standards. The panel also heard
a presentation by a non-member company on its
reproduction/developmental testing with terpineol for
REACH compliance.
Group Summaries
Group summaries on the following structural classes
were reviewed: alkyl cyclic ketones, para-alkyl phenols
and aromatic hydrocarbons. Many of these included
functional ingredients and materials which will be
supported largely by companies. Group human health
testing considerations included studies on: benzyl acetone
subchronic, comparative in vitro metabolism,
isobornyl acetate reproduction, p-methoxybenzaldehyde
reproduction, alpha-hexyl cinnamic aldehyde
skin absorption/metabolism, epoxides dermal sensitization,
allyl ester dermal sensitization, alkyl cyclic
alcohols dermal sensitization, and p-methylanisole
reproduction.
Environmental Strategy
The Panel discussed an environmental strategy
document which had been developed by the IFRA
Environmental Task Force. The first environmental group
summary on macrocyclic materials and 2 other papers
were accepted for publication. Member company
information was requested for a planned life cycle
assessment project to look at the environmental
impact of manufacturing processes. Customer
companies also have asked for hazard assessment
of naturals. The panel discussed the role of socioeconomic
analysis in environmental risk assessment
in light of a recent ECETOC Task Force report
stewarded by Peter Calow.
Following the panel meeting,
an INFOX was held in
Brussels, continuing the
tradition of sharing RIFM
research and providing
an opportunity for scientific
networking. In addition to staff discussion of
human health, environmental and respiratory programs,
this year’s session included
• Presentations on the data accumulation program:
• Chemical regulations in Japan and Asia
• The role of pathology in safety
evaluations
• Relevant mechanisms in
airway hyper-reactivity
and asthma
• An update on IFRA
Standards and the
compliance program
As part of the INFOX,
a special session on
alternatives to animal
testing addressed cellbased
assays, sensitization
methods research,
Cosmetics Europe’s strategy
for skin sensitization and
development of peptide
reactivity assays.
12 21st Century Pathways and People www.rifm.org rifm@rifm.org

In September, the panel met in Barcelona, Spain,
where, as last year, the European Society of Contact
Dermatitis provided an ancillary learning opportunity.
Dr. Helmut Greim provided a primer on mixture
toxicity, covering the opinion of DG Sanco’s 3 scientific
committees. Notably the opinion recommends:
additivity should be assumed for components with
similar modes of action, TTC and QSAR are appropriate
methodologies, and for ecotoxicology, the use of
Predicted No-Effect Concentration is for protection of
populations and not individuals.
Information on the DAPG/accelerated program was
reviewed, using the plan presented to the RIFM
Strategic Advisory Group. A positive outcome of
low priority analysis may be a reduced fragrance
palette, which perhaps would enable the industry to
better support remaining ingredients. One potential
issue might be differing safety evaluations, if providers
are responsible for their individual materials. The
panel also developed a plan to handle the additional
workload which would be created by increasing the
amount of data to be reviewed, and made allowance
for extra time to be spent in 2012.
Professor Bruze presented on elicitation and induction
and relevance of a positive patch test to true
allergy. RIFM has received much credit from the
European dermatology community for supporting
Dr. Ann Therese Karlberg’s work on oxidation. The
group summary on alkyl cyclic ketones was agreed.
Group testing items included terpineol reproduction,
acetoxydihydrodicyclopentadione subchronic,
10-undecenal subchronic, lauric aldehyde subchronic,
p-methoxybenzaldehyde reproduction and
methyl anthranilate developmental. Use level testing
discussions involved ethyl maltol phototoxicity,
Tagete phototoxicity and Sandalwood oil photoallergenic
potential.
The computational fluid dynamics model was completed
in the respiratory program, and in vivo studies
were completed for limonene and 2,3-pentanedione.
Priority materials for environmental testing also were
agreed upon.
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2011 Annual Report
13

Human Health Science
Research
Epidemiology Study
The European Dermato-Epidemiology Network
(EDEN) Global Study on the Prevalence of Contact
Allergy to Fragrances was completed in Europe in
2011. The data are being compiled and analyzed.
A full report is expected in 2012. The study will
provide data on the prevalence of contact allergy to
fragrances in the general population in different
countries, establishing a standardized methodology
and facilitating international collaboration.
From the beginning, this was an original landmark
endeavor promoted by the RIFM Expert Panel. The
study was designed to conduct, with the utmost
scientific rigor, an analysis of the baseline sensitivity
to fragrances in heterogeneous populations in
multiple and diverse centers in Europe. The full study
was implemented and spread over a 3-year period at
the request of the RIFM Board to maximize efficient
use of resources. As stipulated by the study protocol,
>3,050 of the total of more than 12,000 subjects
enrolled were patch-tested, involving approximately
500 subjects at each of the six centers.
Elicitation Threshold Study in Humans
The aim of this study is to determine the threshold
for elicitation of allergy and irritation using two methods—patch
testing and repeated open application
testing. Two pilots for the elicitation threshold study for
eugenol have been completed at the clinic of
Dr. Magnus Bruze, at Malmo University Hospital. The
protocol was revised and Dermatology groups in three
major geographical areas, 2 North American, 3 European,
and 3 Japanese centers, have agreed to participate
in the full study. Testing at the European clinics is
planned for 2012.
The pilot study has been accepted for publication in the
scientific peer-reviewed journal Dermatitis. The article is
titled ‘Does the new standard for eugenol designed to
protect against contact sensitization protect those sensitized
from elicitation of the reaction?’
14 21st Century Pathways and People www.rifm.org rifm@rifm.org

Update on the QRA
The implementation of the dermal sensitization
Quantitative Risk Assessment (QRA) approach
continued with the publication of the 46th Amendment
to the IFRA Code of Practice. The new Amendment included
6 new Standards based on the QRA. A revised
QRA Booklet (Version 6.0) was issued at the same
time. This document can be found on RIFM’s website at
http://www.rifm.org/publications-details.php?id=16. As
with previous Amendments, some of the new IFRA Standards
restrict fragrance ingredients that can be found in
other sources such as essential oils.
Human Health Methodology
Alternative Meetings and Interactions
RIFM continues to evaluate and support the development of
alternative methodologies. In 2011, RIFM continued participation
in efforts to develop the Tissue Metabolism Simulator – Skin
Sensitization (TIMES – SS).
RIFM collaborated with member companies to evaluate in vitro
hazard assessment paradigms for skin sensitization. Partnering
with Givaudan, the utility of the SkinEthic model to reconcile
suspected irritant responses in the LLNA was evaluated.
With Alberto-Culver, the CeeTox method for identifying potential
contact allergens was explored.
RIFM staff participated in the In Vitro Alternatives
Forum (Alexandria, Va.), the meeting provided the
opportunity to interact with regulators, scientists and
industry specialists concerned with the development of
alternatives methodologies.
At the 12th International Conference on Perspectives
in Percutaneous Penetration, Jon Lalko presented
the industries Quantitative Risk Assessment (QRA)
approach to evaluating potential skin sensitizers.
Human Health Testing
Aldehydes / Benzaldehyde and Derivatives
Several dermal sensitization studies were completed for materials
in this group, including Human Repeat Insult Patch Tests
(HRIPTs) for key members of the group—p-methoxybenzaldehyde,
piperonal, vanillin and vanillin isobutyrate. A 14-day acute
study is in progress on p-methoxybenzaldehyde, with both
dermal and oral administration, in preparation for an enhanced
1-generation reproduction study.
Alcohols Alkyl Cyclic
In vitro metabolism and in vivo toxicokinetic studies are
in progress on terpineol and will provide valuable data
when designing the planned reproduction study.
Allyl Esters
A dosage-range finder reproduction study was
completed on allyl cyclohexanepropionate.
Aldehydes Straight Chain Saturated
An enhanced 90-day subchronic toxicity study is in
progress on lauric aldehyde.
Aldehydes Straight Chain Unsaturated
An enhanced 90-day subchronic toxicity study is in
progress on 10-undecenal.
Anthranilates
A developmental toxicity study is in progress on
methyl anthranilate.
Esters/Cyclic Alcohol Simple Acid Ester/
Bicyclo/Bridged/Saturated/Secondary
An enhanced one-generation reproduction study was
completed on isobornyl acetate.
Esters/Cyclic Alcohol Simple Acid Ester/Tricyclo
An enhanced 90-day subchronic toxicity study is in
progress on acetoxydihydrodicyclopentadiene.
Ketones Aromatic
An enhanced 90-day subchronic toxicity study was
completed on benzyl acetone.
Substituted Cinnamyl Aldehydes
A micronucleus test is in progress on o-methoxycinnamaldehyde.
In Vitro Comparative Metabolism Studies
As a first step in RIFM’s Reproduction Testing Paradigm,
in vitro comparative metabolism studies are in progress
for 19 fragrance materials using hepatocytes from
humans, rats, rabbits and in a few cases mice.
Experimental Sensitization Studies
The Local Lymph Node Assay (LLNA) continues to provide
a valuable data point in the conduct of QRAs for the induction
of sensitization. In 2011, over twenty LLNAs were
conducted in support of research and testing initiatives.
The data from the assays, evaluated by the Expert Panel,
will guide future human testing and be incorporated into
assessments of each material. Experience shows that
results of the LLNA correlate closely to No Observed Effect
www.rifm.org rifm@rifm.org
2011 Annual Report
15

Human Health Science
Levels in human confirmatory studies for the induction of
contact sensitization. This correlation allowed LLNA data
to contribute to weight of evidence risk assessments and
provides guidance for conducting human studies. Over
the past year, a robust summary of RIFM’s available LLNA
data for 52 fragrance materials that also have available
HRIPT data has been provided in support of ongoing discussions
with the SCCP.
In addition to routine LLNAs, B220 assays were
conducted on high purity samples of linalool, linalyl acetate
and nerolidol. The B220 assay is an experimental method
designed to provide information to help identify false positives,
due to irritation, in the LLNA.
Use Level Testing
As part of RIFM’s systematic test program, a number
of routine and research oriented studies were
conducted in 2011. The materials investigated were
tested to support current use levels or for an IFRA Standard.
To confirm a lack of sensitization potential on select
fragrance ingredients, 8 HRIPTs and 1 human and 1
mouse phototoxicity study were carried out.
Consortia
Vetiveryl Acetate Consortium
In response to an opinion issued by the SCCP, a consortium
of interested parties was formed to support vetiveryl
acetate. Two in vitro chromosome aberration studies
were conducted, in CHO and HPBL cells. A 28-day
subchronic study was completed. At the request of the
consortia, a 3T3 Neutral Read Uptake study was completed
to evaluate potential phototoxicity.
Styrax and Opoponax Consortium
RIFM continues to work with companies interested in
the support of styrax and opoponax. Over the past year,
LLNAs were completed and HRIPTs planned to provide
data for future risk assessments to support the use of
these materials.
Group Summaries and Fragrance Material Reviews
RIFM Fragrance Ingredient Study
Among The Top Ten Most Cited
Papers Published In Food And
Chemical Toxicology
A toxicologic and dermatologic assessment
of cyclic and non-cyclic terpene
alcohols when used as fragrance ingredients,
Belsito, D., Bickers, D., Bruze,
M., Calow, P., Greim, H., Hanifin, J.M.,
Rogers, A.E., Saurat, J.H., Sipes, I.G.,
Tagami, H., 2008 Food and Chemical
Toxicology 46 (2), pp. 446-475, ranks
number two. Scientific publishing giant
Elsevier released its top cited papers
based on statistics from Scopus, the
largest abstract and citation database
of research literature and quality web
sources covering nearly 18,000 titles
from more than 5,000 publishers.
More RIFM studies are highlighted in
the statistics provided by Elsevier. The
fourth most downloaded from Food
and Chemical Toxicology in 2010 is
the RIFM Special Review Supplement,
A safety assessment of saturated
branched chain alcohols when used
as fragrance ingredients, Belsito, D.,
Bickers, et al., 2010 Food and Chemical
Toxicology 48 (Suppl 4), pp. S1-
S46. RIFM’s Human Health research
studies on fragrance ingredients are
available from the RIFM web site at
www.rifm.org in the RIFM Human
Health Science Program area or the
Publications section.
The first and second most downloaded
from Food and Chemical Toxicology
in 2011 are A toxicological and
dermatological assessment of macrocyclic
lactone and lactide derivatives
when used as fragrance ingredients,
Belsito, D., Bickers, D., Bruze, M.,
Calow, P., Dagli, M.L., Fryer, A.D.,
Greim, H., Miyachi, Y., Saurat, J.H.,
Sipes, I.G., 2011 Food and Chemical
Toxicology, 49, (Suppl 2), pp. S219-
S241 and A toxicological and dermatological
assessment of macrocyclic
ketones when used as fragrance
ingredients, Belsito, D., et al, 2011
Food and Chemical Toxicology, 49,
(Suppl 2), pp. S126-S141.
To date RIFM has published a total of
12 Group Summaries and more than
230 Fragrance Material Reviews (FMRs)
on individual fragrance ingredients.
16 21st Century Pathways and People www.rifm.org rifm@rifm.org

Five Group Summaries Accepted
For Publication
1. A Toxicological and Dermatological
Assessment of Macrocyclic Ketones
when used as Fragrance Ingredients
2. A Toxicological and Dermatological
Assessment of Macrocyclic Lactone
and Lactide Derivatives when used
as Fragrance Ingredients
3. A Toxicological and Dermatological
Assessment of Cinnamyl Phenylpropyl
Materials when used as Fragrance
Ingredients
4. A Toxicological and Dermatological
Assessment of Aryl Alkyl Alcohols
when used as Fragrance Ingredients
5. A Toxicological and Dermatological
Assessment of Ketones Cyclopentanones
and Cyclopentenones when
used as Fragrance Ingredients
24 Fragrance Material Reviews
Published
• Cycloheptadeca-9-en-1-one
• Cyclohexadecanone
• 5-Cyclohexadecen-1-one
• Cyclohexadec-8-en-1-one (mix of cis and
trans isomer)
• Cyclopentadecanone
• 4-Cyclopentadecen-1-one
• 4-Cyclopentadecen-1-one, (Z)-
• Cyclotetradecan-1-one
• 3-Methyl-1-cyclopentadecanone
• 3-Methylcyclopentadecenone (mixed
isomers)
• 3-Methylcyclotridecan-1-one
• Ethylene brassylate
• Ethylene dodecanedioate
• Hexadecanolide
• omega-6-Hexadecenlactone
• 16-Hydroxy-7-hexadecenoic acid lactone
• Oxacycloheptadec-10-ene-2-one
• Oxacyclohexadecane-2,13-dione
• (E) and (Z)-Oxacyclohexadec-(12 or
13)-en-2-one
• 10-Oxahexadecanolide
• 11-Oxahexadecanolide
• 12-Oxahexadecanolide
• omega-Pentadecalactone
• 3-Phenyl-1-propanol
• 3-Phenylpropyl cinnamate
• 3-Phenylpropyl isobutyrate
Three Group Summaries and
FMRs Submitted to Journal
Aryl Alkyl Alcohols Simple Acid Esters
• (4-Methoxyphenyl)methyl Isobutyrate
• 1,1-Dimethyl-2-phenylethyl acetate
• 1,1-Dimethyl-2-phenylethyl butyrate
• 1,1-Dimethyl-2-phenylethyl formate
• 1,1-Dimethyl-2-phenylethyl isobutyrate
• 1,1-Dimethyl-2-phenylethyl propionate
• 1,2-Ethanediol, 1-phenyl-, 1,2-diacetate
• 1,3-Benzodioxole-5-propanol, .α.-methyl-,
5-acetate
• 1,3-Dimethyl-3-phenylbutyl acetate
• 1-Phenyl-3-methyl-3-pentyl Acetate
• 2-(p-Tolyloxy)ethyl Acetate
• 2,4-Dimethylbenzyl Acetate
• 2-Hydroxy-2-phenylethyl acetate
• 2-Methyl-4-phenyl-2-butyl acetate
• 2-Phenoxyethyl Isobutyrate
• 2-Phenoxyethyl propionate
• 2-Phenylpropyl Acetate
• 3-Phenyl-3-buten-1-yl acetate
• 3-Phenylpropyl acetate
• 4-Methylbenzyl Acetate
• Anisyl Acetate
• Anisyl Formate
• Anisyl Propionate
• Benzyl 2-Hydroxypropionate
• Benzyl Acetate
• Benzyl Butyrate
• Benzyl Formate
• Benzyl Isobutyrate
• Benzyl Propionate
• Carbonic acid, methyl phenylmethyl ester
• p-Anisyl acetate
• Phenethyl acetate
• Phenethyl butyrate
• Phenethyl formate
• Phenethyl isobutyrate
• Phenethyl Propionate
• Piperonyl Acetate
• p-Isopropylbenzyl Acetate
• α-Methylbenzyl Acetate
• α-Methylbenzyl Isobutyrate
• α-Methylbenzyl Propionate
Aryl Alkyl Alcohols
• 1-Phenyl-3-methyl-3-pentanol
• 2-(4-Methylphenoxy)ethanol
• β-methoxy-benzeneethanol
• β,β,3-trimethyl-benzenepropanol
• α,α-Dimethylphenethyl alcohol
• 2,2-Dimethyl-3-phenylpropanol
• α-Isobutylphenylethyl alcohol
• β-Methylphenethyl alcohol
• 2-Methyl-4-phenyl-2-butanol
• 2-Methyl-4-phenylpentanol
• 2-Phenoxyethanol
• α-Propylphenethyl alcohol
• o-Tolylethanol
• α,α,4-Trimethylphenethyl alcohol
• p-Isopropylbenzyl alcohol
• 2-Phenyl-2-propanol
• p-α,α-Trimethylbenzyl alcohol
• 2-Benzylheptanol
• 2-p-Tolylethanol
• Anisyl alcohol (o-m-p-)
• 2-Methyl-5-phenylpentanol
• 3-Methyl-1-phenylbutan-2-ol
• 2-(3-Methylphenyl) Ethanol
• α-Methylbenzyl alcohol
• p-Tolyl alcohol
• Anisyl alcohol
• Benzyl alcohol
• Phenylethyl alcohol
• 3-Methyl-5-phenylpentanol
• 4-Phenyl-3-buten-2-ol
Ketones Cyclopentanone and
Cyclopentenone
• 2-(3,7-Dimethyl-2,6-octadienyl)cyclopentanone
• 2-(p-Menth-1-ene-10-yl) cyclopentanone
• 2,2,5-Trimethyl-5-pentylcyclopentanone
• 2-cyclopentylcyclopentanone
• 2-Heptylcyclopentanone
• 2-Heptylidenecyclopentan-1-one
• 2-Hexylcyclopentanone
• 2-Hexylidene cyclopentanone
• 2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one
• 2-Pentylcyclopentan-1-one
• 3-Ethyl-2-hydroxy-2-cyclopenten-1-one
• 3-Methyl-2-(2-pentenyl)-2-cyclopenten-1-one
• 3-Methyl-2-(n-pentanyl)-2-cyclopenten-1-one
• 3-methyl-2-(pentyloxy)-2-cyclopenten-1-one
• 3-Methyl-2-pentylcyclopentan-1-one
• cis-Jasmone
• Cyclopentanone
• Cyclotene propionate
• Dihydroisojasmone
• Hexenylcyclopentanone
• Isojasmone
• Methyl 3-oxo-2-(pent-2-enyl)cyclopentaneacetate
• Methyl dihydrojasmonate
• Methyl hexyl oxo cyclopentanone carboxylate
• Methyl jasmonate
Cinnamyl Phenylpropyl Materials
• 3-Phenyl-1-propanol
• 3-Phenylpropyl cinnamate
• 3-Phenypropyl isobutyrate
4 groups will be submitted in 2012.
Alkyl Cyclic Ketones
Aromatic Ketones
Alkyl and Cyclic Alkyl Nitriles
Aryl and Aryl Alkyl Nitriles
www.rifm.org rifm@rifm.org
2011 Annual Report
17

Human Health Science
Flavor or Fragrance Ingredient Data Sheets (FFIDSs)
In 2011, RIFM Human Health Staff compiled a
Master List of Materials. The list prioritizes materials
for preparation of FFIDSs and review by the IFRA/
IOFI Global Harmonic System (GHS) Task Force for
assignment of hazard phrases.
All European and US hazard phrases are in the
RIFM Database and the IFRA/IOFI Labeling Manual
can be downloaded from there. Staff worked with
members of the IFRA/IOFI GHS Task Force on the
assignment of OSHA hazard phrases for materials
that will target organ endpoints. All OSHA hazard
phrases are also in the RIFM Database.
In 2011, FFIDS covering 73 materials were issued
and are available from the RIFM Database.
• Acetic acid, anhydride, reaction products with 1,5,10-
trimethyl-1,5,9-cyclododecatriene
• 1-(2-Benzofuranyl)ethanone
• Benzoic acid, 2-.(..(.(4-methoxyphenyl)
methylene.).amino.).-,methyl ester
• Benzoic acid, 2-[[3-(4-methoxyphenyl)-2-methylpropylidene]amino]-,
methyl ester
• Benzyl methyl ether
• 2-tert-Butylcyclohexanone
• Butyl 2-methylvalerate
• 3-(p-tert-Butylphenyl)-2-methylpropanol
• sec-Butylquinoline
• Cuminyl nitrile
• Cyclododecyl formate
• Cyclohexadecanone
• Cyclohexanecarboxylic acid, 1,4-dimethyl-, methyl ester,
trans-
• Cyclohexane, 1-(1,1-dimethylpropyl)-4-ethoxy-, trans-
• 1-Cyclohexylethanol
• Cyclooct-4-en-1-yl methyl carbonate
• Cyclopropanecarboxylic acid, (3Z)-3-hexenyl ester
• Cyclopropanemethanol, 1-methyl-2-[(1,2,2-trimethylbicyc-
lo[3.1.0]hex-3-yl)methyl]-
• 1-Cyclopropylmethyl-4-methoxybenzene
• Diethyl 1,4-cyclohexane dicarboxylate
• 2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal
• (,5Z)-2,6-Dimethylocta-3,5-dien-2-ol
• (E)-6,10-Dimethylundeca-5,9-dien-2-yl acetate
• 6,10-Dioxaspiro[4.5]decane, 8,8-dimethyl-7-
(1-methylethyl)-
• Dodecahydro-3,8,8,11a-tetramethyl-5H-3,5aepoxynaphth[2,1-c]oxepin
• 2-Ethoxy-2,6,6-trimethyl-9-methylenebicyclo[3.3.1]nonane
• (2-endo,3-exo)-Ethyl 3-(1-methylethyl)bicyclo[2.2.1]hept-
5-ene-2-carboxylate
• N-Ethyl-N-(3-methylphenyl)propionamide
• Ethyl 2,3,6,6-tetramethylcyclohex-2-ene-1-carboxylate
• 4-Heptanol, 2,6-dimethyl-, acetate
• 4(3a,4,5,6,7,7a-Hexahydro-4,7-methano-1H-inden-6-yl)-
3-methyl-3-buten-2-ol
• (1a.alpha.,4.alpha.,7a.alpha.)-1a,3,3,4,6,6-Hexamethyl-
1a,2,3,4,5,6,7,7a-octahydronapth[3,3-b]oxirene
• Hexanoic acid, 6-(acetyloxy)-, ethyl ester
• 4-(Isopropyl)cyclohexyl propionate
• 2-Isopropyl-N,2,3-trimethylbutyramide
• 1-p-Menthene-8-thiol
• 2-(p-Menth-1-ene-10-yl)cyclopentanone
• l-Menthyl lactate
• 6-Methoxy-2,6-dimethylheptan-1-al
• 7-Methoxy-3,7-dimethyloct-1-ene
• α-Methylcinnamic alcohol
• Methyl cyclohexadiene (mixture of isomers)
• Methyl linoleate
• 2-(Methylpropyl)quinoline
• 2-(1-Methylpropyl)-1-vinylcyclohexyl acetate
• Methyl 2,6,6-trimethylcyclohex-2-ene-1-carboxylate
• 1-Nonanol, 2,4,6,8-tetramethyl-,acetate
• Octanenitrile
• 1-Oxaspiro[4.5]decan-2-one, 8-methyl-
• 3,4,5,6,6-Pentamethylheptan-2-ol
• 1,6,7,8-Tetrahydro-1,4,6,6,8,8-hexamethyl-as-indacene-
3(2H)-one
• Theaspirane
• o-Tolylethanol
• 4,7,7-Trimethyl-6-thiabicyclo[3.2.1]octane
Revised FFIDS
• Acetaldehyde ethyl cis-3-hexenyl acetal
• Benzaldehyde glyceryl acetal
• Benzyl laurate
• α-Butylcinnamaldehyde
• Butyl 10-undecenoate
• Carveol
• Caryophyllene oxide
• Cedryl formate
• 9-Cycloheptadecen-1-one
• Decahydro-β-naphthol
• Diethyl sebacate
• α,α-Dimethyl-p-ethylphenylpropanal
• 2-Heptyltetrahydrofuran
• Isoamyl benzoate
• Maltyl isobutyrate
• α-Methylcinnamic alcohol
• 2-Methyl-3-(p-isopropylphenyl)propionaldehyde
• Myrcene
• Nona-2-trans-6-cis-dienal
18 21st Century Pathways and People www.rifm.org rifm@rifm.org

Publications
Accepted for Publication
1. Chemical Reactivity Measurements: potential for characterization
of respiratory chemical allergens (2011). J. Lalko, I.
Kimber, R.J. Dearman, G.F. Gerberick, K. Sarlo, A.M. Api.
Toxicology In Vitro 25: 433-445.
2. IFRA/RIFM QRA Information Booklet, Version 6.0, June
2011 http://www.rifm.org/publications-details.php?id=16
3. A toxicological and dermatological Assessment of macrocyclic
ketones when used as fragrance ingredients. D.
Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D.
Fryer, H. Greim, Y. Miyachi, J. H. Saurat, and I. G. Sipes
Food and Chemical Toxicology, 49(2), 2011.
4. Fragrance material reviews 9 macrocyclic ketones manuscripts.
Food and Chemical Toxicology, 49(2), 2011.
5. A toxicological and dermatological Assessment of macrocyclic
lactone and lactide derivatives when used as
fragrance ingredients. D. Belsito, D. Bickers, M. Bruze, P.
Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J. H.
Saurat, and I. G. Sipes Food and Chemical Toxicology,
49(2), 2011.
6. Fragrance material reviews 12 macrocyclic lactone and
lactide derivatives manuscripts. Food and Chemical Toxicology
49(2), 2011.
7. A toxicological and dermatological Assessment of cinnamyl
phenylpropyl materials when used as fragrance
ingredients. D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L.
Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J. H. Saurat, and I.
G. Sipes Food and Chemical Toxicology, 49(2), 2011.
8. Fragrance material reviews 3 cinnamyl phenylpropyl
materials manuscripts. Food and Chemical Toxicology,
49(S2),2011.
9. A toxicological and dermatological Assessment of aryl
alkyl alcohols when used as fragrance ingredients. D. Belsito,
D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer,
H. Greim, Y. Miyachi, J. H. Saurat, and I. G. Sipes Food
and Chemical Toxicology, in press.
10. Fragrance material reviews 30 of aryl alkyl alcohols materials
manuscripts. Food and Chemical Toxicology, in press.
Submitted for Publication
1. A toxicological and dermatological assessment of aryl
alkyl alcohols simple acid esters when used as fragrance
ingredients. D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L.
Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J. H. Saurat, and I.
G. Sipes. Food and Chemical Toxicology.
2. Fragrance material reviews 41 of aryl alkyl alcohols simple
acid esters materials manuscripts. Food and Chemical
Toxicology.
3. A toxicological and dermatological assessment of ketones
cyclopentanones and cyclopentenones when used as
fragrance ingredients. D. Belsito, D. Bickers, M. Bruze, P.
Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J. H.
Saurat, and I. G. Sipes. Food and Chemical Toxicology, .
4. Fragrance material reviews 25 of ketones cyclopentanones
and cyclopentenones materials manuscripts. Food and
Chemical Toxicology.
Manuscripts in Progress
1. A toxicological and dermatological assessment of alkyl
cyclic ketones when used as fragrance ingredients.
2. A toxicological and dermatological assessment of aromatic
ketones when used as fragrance ingredients.
3. A toxicological and dermatological assessment of alkyl and
cyclic alkyl nitriles when used as fragrance ingredients.
4. A toxicological and dermatological assessment of aryl and
aryl alkyl nitriles when used as fragrance ingredients.
5. A toxicological and dermatological assessment of meta,
ortho-alkylphenols when used as fragrance ingredients.
6. A toxicological and dermatological assessment of meta,
ortho-alkoxyphenols when used as fragrance ingredients
7. A toxicological and dermatological assessment of parahydroxybenzoates
when used as fragrance ingredients.
Presentations
1. Status of the Dermal QRA Approach for Fragrance Materials.
J. Lalko. EPAA Cross-sector workshop: Optimized testing
strategies for skin sensitization-LLNA and beyond. Sept.
19, Brussels, Belgium
2. RIFM Human Health Sciences Program. A.M. Api
S.C. Johnson. Feb. 16.
3. Changes in the level of expression and frequency of B220
positive lymphocytes may discriminate more accurately
between contact allergen and skin irritants. R.J. Dearman, I.
Kimber, A.M. Api and J. Lalko, British Toxicology Society
4. Preferential Reactivity of Contact and Respiratory Low
Molecular Weight Chemical Allergens under Competitive
Conditions. J. Lalko, I. Kimber, R.J. Dearman, F. Gerberick,
A.M. Api and L.W.Smith. Society of Toxicology (SOT) 50th
Annual Meeting, March 6-10, Wash., D.C., USA.
5. Allergen Exposure Results in Changes in the Level of Expression
and Frequency of B220+ Lymphocytes. S. Khan,
I. Kimber, R.J. Dearman, J.F. Lalko and A.M. Api. SOT 50th
Annual Meeting, March 6-10, Wash., D.C., USA.
6. Evaluation of A Combined Dermal Developmental And
Perinatal/Postnatal Reproduction Toxicity Study Of PEA
(Phenethyl Alcohol) In Rats-Including An Examination
Skeletal Variants Postnatally. V.T. Politano, E.M. Lewis, A.M.
Hoberman, R.M. Diener and A.M. Api. SOT 50th Annual
Meeting, March 6-10, Wash., D.C., USA.
7. A Group Approach For Human Health Safety Assessment
Of Fragrance Ingredients. A.M. Api, S. Bhatia, C. Letizia, D.
McGinty, J. Scognamiglio and L.W. Smith. SOT 50th Annual
Meeting, March 6-10, Wash., D.C., USA.
8. Oral (Gavage) One-Generation Reproduction Study of
Citronellyl Nitrile in Rats, With An Evaluation Through Sexual
Maturity in the F1 Generation. J. Scognamiglio, D. McGinty,
V.T. Politano, and A.M. Api. SOT 50th Annual Meeting,
March 6-10, Wash., D.C., USA.
Symposia
SOT 2011, Informatics and Social Media Essentials for Toxicologists.
Sneha Bhatia, Co-chair & Speaker.
www.rifm.org rifm@rifm.org
2011 Annual Report
19

Environmental Science
Bioaccumulation Assessment of
Natural Complex Substances (NCSs)
Drs. Michael McLachlan and Matthew McLeod, of Stockholm
University, through the European Chemical Industry
Council’s (Cefic’s) Long-Range Research Initiative Programme
(LRI). provided better assessment methods for
bio-accumulation in fish. The research group has proposed
the development of a method to assess bioaccumulation
(B) of multi-constituent substances following
the methods developed under the Cefic LRI. It is envisioned
that this method can be applied to NCSs as a
whole or prepared fractions from the whole NCS. Stockholm
University will be taking a phased approach working
towards this as the end product of the initial study.
The proposal was discussed with the IFRA Environmental
Task Force (ETF) and contracted with the university. In
the first phase, the research team, in collaboration with
the IFRA ETF, will select a group of fragrance materials
with measured BCFs to use in method development.
For the future, there is a plan to develop a method to
examine persistence in wastewater.
Life Cycle Assessment Project
As part of the RIFM Environmental Strategy, a Life
Cycle Assessment project was identified as a key milestone
activity for RIFM and the industry. This project,
using the consultancy P-E International (formerly Five
Winds), was funded in late 2010 and commenced
over the summer of 2011. An industry working group
of major fragrance material suppliers (including Small
to Medium size Enterprises (SMEs) and their customers
are providing data for this project. The study is a
‘cradle - to - gate’ review of fragrance compounding
(from receipt of goods through manufacturing and up
to the point it leaves the supplier for the customer).
The work group identified five key chemical classes
(ketones, hydrocarbons, alcohols, esters, and aldehydes)
and natural complex substances that represent
the major processing steps for most fragrance ingredients.
Presently the project is in the data collection
phase. The expected completion of this project is 1st
Quarter 2012.
20 21st Century Pathways and People www.rifm.org rifm@rifm.org

RIFM Testing Program Supports
IFRA Environmental Standards
RIFM continues to focus its testing program on materials selected as high priority. Using the RIFM Environmental
Framework, risk and screening assessments for hazard look at persistence and bioaccumulation. The
studies and test plans are developed in close collaboration with the IFRA Environmental Task Force and the
Expert Panel Environmental Adjunct Group. The tables provide a summary of the studies performed and any
recent revisions to the risk and hazard characterizations of the listed materials from their original screening
assessments.
2011 Revised Risk and Hazard Assessments in Support of the IFRA Environmental Standards
Based on RIFM and Member Provided Data
Material
Assessment
Benzyl Acetate (140-11-4) RQ < 1
Isobornyl Acetate (125-12-2) RQ < 1
4-tert Butylcylohexyl Acetate (3056-64-2) RQ < 1
a, a-Dimethylphenethyl Acetate (151-05-3) RQ < 1
a-Terpineol Acetate (80-26-2) RQ < 1
1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, [3R-(3α,3α,β,6β,7β,8α,α)] (6β) (Cedramber) (19870-74-7)
Not P
Isolongifolanone (Piconia) (23787-90-8)
Not B
Terpineol (8000-41-7)
Not P
1,6-Octadiene, 7-methyl-3-methylene-(Myrcene) (123-35-3)
Not P
3-Cyclohexene-1-carboxaldehyde, 4-(4-methyl-3-penten-1-yl)-(Myrac aldehyde) (37677-14-8)
Not P
3-Cyclohexene-1-carboxaldehyde, 1-methyl-3-(4-methyl-3-pentenyl)-(Precyclemone B) (52475-86-2)
Not P
2-Buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (Bacdanol) (28219-61-6)
Not P
4-Penten-1-one, 1-(5,5-dimethyl-1-cyclohexen-1-yl)- (Galbanone) (56973-85-4)
Not P
www.rifm.org rifm@rifm.org
2011 Annual Report
21

Environmental Science
RIFM Environmental Testing Status (as of 4Q 2011)
Risk Based Material Selection(Screening
Risk Quotients requiring additional study)
Hazard Based Material Selection (Screening P or B estimates
indicate insufficient data)
Material (CAS #)
Study/Method
Status
Material (CAS #)
Study/Method
Status
Decanal (112-31-2)
Daphnia Chronic
Study/ OECD 211
In Progress
1H-3a,7-Methanoazulene, octahydro-
6-methoxy-3,6,8,8-tetramethyl-,[3R-
(3a,3a,β,6β,7β,8a,a)] (6β) (Cedramber)
(19870-74-7)
Ready Biodegradation Test
(OECD 310)
Completed
a-Hexylcinnamaldehyde
(101-86-0)
Daphnia Chronic
Study/OECD 211
Completed
2-tert- Amylcyclohexyl acetate (67874-
72-0)
Modified Ready Test
In Progress
3a,4,5,6,7,7a-
Hexahydro-4,7-
methano-1H-indenyl
propionate (Mixture of
Isomers) (68912-13-0)
Daphnia Chronic
Study/OECD 211
In Progress
2-Naphthalenecarboxaldehyde,
1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-
(Melafleur) (68991-97-9)
Modified Ready Test
In Progress
Isobornyl acetate (125-
12-2)
a-Terpineol acetate
(80-26-2)
Fish, Daphnia, Algae
Acute Studies/ OECD
203, OECD 202 and
OECD 201
Completed
Fish, Daphnia, Algae
Acute Studies/ OECD
203, OECD 202 and
OECD 201
Completed
4-Penten-1-one, 1-(5,5-dimethyl-1-cyclohexen-1-yl)-
(Galbanone) (56973-
85-4)
Isolongifolanone (Piconia) (23787-90-8)
Modified Ready Test
Completed
Modified Ready Test;
Modified Bioaccumulation
Test/ OECD 305
Completed
Benzyl Acetate (140-
11-4)
Daphnia Acute Study/
OECD 202
Completed
Terpineol (8000-41-7)
Ready Biodegradation Test
(OECD 310)
Completed
4 Tert butylcyclohexyl
acetate (3056-64-2)
Fish and Algae Acute
Studies/ OECD 203
and OECD 202
Completed
1,6-Octadiene, 7-methyl-3-methylene-
(Myrcene) (123-35-3)
Ready Biodegradation Test
(OECD 310)
Completed
a, a- Dimethyl
phenethyl acetate
(151-05-3)
Fish Acute Study/
OECD 203
Completed
3-Cyclohexene-1-carboxaldehyde,
4-(4-methyl-3-penten-1-yl)- (Myrac
aldehyde) (37677-14-8)
Ready Biodegradation Test
(OECD 310)
Completed
Methyl Ester of rosin
(8050-15-5)
Fish, Daphnia, Algae
Acute Studies/OECD
203, OECD 202 and
OECD 201
In Progress
3-Cyclohexene-1-carboxaldehyde,
1-methyl-3-(4-methyl-3-pentenyl)- (Precyclemone
B) (52475-86-2)
Ready Biodegradation Test
(OECD 310)
Completed
2-Buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-
3-cyclopenten-1-yl)- (Bacdanol)
(28219-61-6)
Activated Sludge/River
Water Die Away (OECD
314 B; OECD 314 D)
Completed
22 21st Century Pathways and People www.rifm.org rifm@rifm.org

Publications
The papers published in 2011 are indicative of the
breadth of the RIFM Environmental Program and the
highly collaborative nature of RIFM’s efforts in advancing
approaches to risk and hazard assessment.
The paper on the use of chemical categories to
establish risk quotients for macrocyclic fragrance
ingredients was a concerted effort between RIFM staff,
the Expert Panel Environmental Adjunct Group and industry
members. Within this paper, background is provided
establishing how chemical categories can be used in our
understanding of the fate and effects of fragrance ingredients
in the environment.
The paper on ecological risk assessment and population
modeling was the result of a workshop RIFM had
co-funded with the European Centre for Ecotoxicology
and Toxicology of Chemicals (ECETOC) at Roskilde
University on this topic in 2009. Co-authors include
Prof. Peter Calow, Ph.D., Department of Environmental,
Social and Spatial Change at Roskilde University
in Denmark and member of the independent Expert
Panel, researchers from Roskilde University and
collaborators from universities in Europe and the US. A
related effort initiated by ECETOC resulted in a recent
Task Force report: Environmental Impact Assessment for
Socio-Economic Analysis of Chemicals: Principles and
Practice. Prof. Calow stewarded this project for ECETOC
with colleagues from industry, RIFM, and the European
Chemical Agency (ECHA) staff participating.
Lastly, the paper on lab to field bioaccumulation is an
extension of RIFM’s active participation in both the
Society of Environmental Toxicology & Chemistry (SETAC)
Bioaccumulation Science Advisory Group and support of
the Health and Environmental Sciences Institute’s (HESI)
bioaccumulation science program. This paper is part of
a special issue of Integrated Environmental Assessment
and Management (IEAM) addressing the critical links between
laboratory measurements of bioaccumulation and
the meaning of these data relative to observations from
the field.
Macrocyclic fragrance materials—a screening-level
environmental assessment using chemical categorization.
(2011) Daniel Salvito, Aurelia Lapczynski, Christen
Sachse-Vasquez, Colin McIntosh, Peter Calow, Helmut
Greim and Beate Escher Ecotoxicology and Environmental
Safety 74(6):1619-29
Adding value to ecological risk assessment with population
modelling (2011) Valery E. Forbes, Peter Calow,
Volker Grimm, Takehiko I. Hayashi, Tjalling Jager, Agnete
Katholm, Annemette Palmqvist, Rob Pastorok, Dan Salvito,
Richard Sibly, Julann Spromberg, John Stark, Richard
A. Stillman Human and Environmental Risk Assessment
(HERA) 17(2) :287-299
Explaining differences between bioaccumulation measurements
in laboratory and field data through use of
a probabilistic modeling approach. (2011)Henriette
Selck, Ken Drouillard, Karen Eisenreich, Bart Koelmans,
Annemette Palmqvist, Anders Ruus, Daniel Salvito, Irv
Schultz, Stewart R, Annie Weisbrod, Nicco van den Brink,
Martine van den Heuvel-Greve. IEAM 8(1):42-63
Presentations
The Environmental Assessment of Fragrance Materials.
D. Salvito. SETAC North America 32nd Annual Meeting,
Boston, MA November 13-17, 2011.
IFRA Environmental Standards: Risk and Hazard Assessment
Update for 2011. A. Lapczynski, D. Salvito. M. Vey.
SETAC North America 32nd Annual Meeting, Boston, MA
November 13-17, 2011.
IFRA Environmental Standards: An industry self-regulation
approach using risk and hazard. A. Lapczynski, D. Salvito,
M. Vey. SETAC Europe 21st Annual Meeting, Milan,
Italy May 15-19, 2011.
www.rifm.org rifm@rifm.org
2011 Annual Report
23

Respiratory Science
Innovative Models for
Respiratory Assessment of Fragrance Materials
Over the past year, the Respiratory Science Program at
RIFM has debuted two new innovative in silico modeling
programs developed in collaboration with experts
from The Hamner Institutes for Health Sciences, Applied
Research Associates and University of North Carolina.
Though each software program can function independently,
both pieces will be integrated into a single program
designed to evaluate exposure and bioavailability
in one complete user-friendly model for high-throughput
analysis. The RIFM 2-Box Air Dispersion Model calculates
the peak air concentration of a single material of
interest under defined consumer use conditions. The
Multiple Path Particle Deposition Model (MPPD) is built
to calculate the concentration of a material within the upper
and lower parts of the respiratory tract. It provides
important information—about behavior and relative kinetics—on
how each material behaves upon inhalation
from different product release scenarios. From this information,
we can determine the actual dose deposited in
different regions of the respiratory tract, which can then
be applied to subsequent studies and data analysis.
The computational information generated is actively, and
successfully, being correlated to data from in vivo noseonly
exposure studies conducted at WIL Research Laboratories.
Once actual air concentrations are calculated, and
the amount that is available in the air is evaluated for
respiratory tract exposure, the data moves further in
the research program into the development of an in
vitro high-throughput assessment method. Our Respiratory
Cellular Cytokine Profiling Project has produced a
feasible co-culture model effectively mimicking the airtissue
interface inside the lung. This model will provide
a mechanism by which to discern materials according
to a profile of in flammatory mediators that may or may
not be produced following exposure in the system.
Our improved evaluation of the inhalation data in the
RIFM Database has allowed us to establish a new
partnership with The Fraunhofer Institute in Hannover,
Germany. The partnership will help us to continue building,
and reinforcing, a foundation for inhalation toxicological
threshold of concern (TTC) calculation and
assessment. With each of the tools we’ve developed,
the TTC method will be integrated as a benchmark
against which our data can be compared and reviewed
for further study.
The Respiratory Science Program remains fully engaged
in projects that are poised to develop efficient research
methods, promote inhalation safety, and address
potential systemic effects of inhaled fragrance materials.
Among the research targets are the respiratory cellular
interactions potentially involved in respiratory sensitization
and asthma, structure-activity relationships, and
application of our newly completed models (both in vitro
and in silico). Evaluation of these targets will allow RIFM
to provide a respiratory safety assessment and subsequent
decision-making process. A decision tree has
been developed, with participation from members of the
Respiratory Science Working Group and Expert Panel, to
provide guidance for future analysis of existing and new
fragrance materials.
24 21st Century Pathways and People www.rifm.org rifm@rifm.org

Publications
Schroeter, J.D., Kimbell, J.S., Asgharian, B., Tewksbury,
E.W., Singal, M. Computational fluid dynamics simulations
of submicrometer and micrometer particle deposition
in the nasal passages of a sprague-dawley rat. Journal
of Aerosol Science, 43(1): 31-44 (2011)
Asgharian, B., Price, O.T., Schroeter, J.D., Kimbell, J.S.,
Jones, L., Singal, M. Derivation of mass transfer coefficients
for transient uptake and tissue disposition of soluble
vapors in lung airways. Annals of Biomedical Engineering,
39(6): 1788-1804 (2011).
Singal, M., Vitale, D., Smith, L.W. Fragranced products
and VOCs. Letter to the Editor, Environmental Health Perspectives,
119 (5): A200 (2011).
Singal, M. Nanoparticle Induced Inflammatory Signaling
in the Lung, academic textbook published by VDM Publishing
House, Ltd.
Asgharian, B., Price, O.T., Schroeter, J.D., Kimbell, J.S.,
Singal, M. A lung dosimetry model of vapor uptake and
tissue disposition. Manuscript accepted for publication in
Inhalation Toxicology (January 2012)
Landscape of New Research Initiatives: Alternative Method
Development and Tools for Inhalation Risk Assessment,
ACI Asthma Science Forum, Alexandria, VA, May
2011
Recipient Of 2011 Best Presentation
First Prize Blue Ribbon
For The Risk Assessment Specialty Section
M. Singal, B. Asgharian, O. T. Price, J. D. Schroeter,
J. S. Kimbell. Modeling vapor uptake and tissue
disposition in human lungs. Society of Toxicology,
March 2011, Wash., D.C.
Manuscripts in Progress
Asgharian, B., Schroeter, J.D., Kimbell, J.S., Singal, M.
Updated, three-dimensional dosimetry models for uptake
of inhaled formaldehyde in the upper respiratory tract of
rats and humans.
Invited chapter regarding pulmonary inflammation in
development for update to the textbook, Comparative
Biology of the Normal Lung (Editor: Dr. Gary Burleson).
Anticipated publication in 2013
Presentations
Lung deposition and dosimetry with multiple path particle
deposition modeling, RIFM Webinar, Dec. 2011
RIFM Respiratory Science Program: alternative method
development and tools for inhalation risk assessment,
IFRA NA/RIFM Member Webinar, Nov. 2011
Transport of semi-volatile liquid droplets in the human
lung, American Association for Aerosol Research, Oct.
2011, Tampa, FL
A novel approach to assess irritant or respiratory allergenic
potential of chemicals in vitro, World Alternatives
Congress, Aug. 2011, Montreal, Canada
RIFM Respiratory Science Consumer Inhalation Testing
Strategies, EPHECT Meeting, May 2011, Kos, Greece
RIFM Respiratory Science Program, RIFM INFOX, May
2011, Brussels, Belgium
J.D. Schroeter, J.S. Kimbell, B. Asgharian, and
M.Singal. Dosimetry of soluble, reactive vapors in
the upper respiratory tract of the sprague-dawley rat
using a computational fluid dynamics model, Society of
Toxicology, March 2011, Was., D.C.
M. Singal, D. Vitale, D. T. Kirkpatrick, F. G. Burleson,
G. Adamson, S. Robison, J. Rose, and L. Smith.
Evaluation of inhalation exposure to aerosolized 2,3-pentanedione
in sprague-dawley rats, Society of Toxicology,
March 2012, San Francisco, CA (Abstract accepted)
D. Vitale, M. Singal, D. T. Kirkpatrick, F. G. Burleson,
G. Adamson, S. Robison, J. Rose, and L. Smith.
Evaluation of Inhalation Exposure to Aerosolized
d-Limonene in Sprague-Dawley Rats. Society of
Toxicology, March 2012, San Francisco, CA (Abstract accepted)
www.rifm.org rifm@rifm.org
2011 Annual Report
25

The RIFM Database
Member Data Contributions Grow
The RIFM Database continues to grow
as RIFM Member companies consistently
submit their study reports on
their own research. Approximately
1,200 member company toxicological
studies were added in 2011. There
are now over 13,000 company studies
in the Database, accounting for more
than 20% of the total number of references.
RIFM Database use has been fairly
stable, hovering around 550,000 subscriber
hits per year. As a result of
GRAS 25, 64 new materials were added
to the database along with over 100
associated references. The Database
was enhanced with updated physical/
chemical property values using the
newest version of Estimation Program
Software (EPI Suite 4.0).
RIFM Sponsored Studies For REACH
TOTAL REACH STUDY SALES
$553,000
The sale of RIFM sponsored studies for
REACH has resulted in significant income
for RIFM. The additional funds are applied to
operations and generating more studies.
$300,000
$250,000
A “Study Request Form” link from the
Database home page aids subscribers in the
process of compiling and requesting RIFM
sponsored studies for REACH.
$200,000
$150,000
$100,000
$50,000
$0
2009 2010 2011
26 21st Century Pathways and People www.rifm.org rifm@rifm.org

RIFM Database Refinements
Material Queries
Subscirbers can now run their own simple queries to
download information by using the “Run Queries on
Materials” link from the home page of the RIFM Database.
It’s easy to select what type of materials, their
identification information and any associated physical
property or risk and safety information for the desired
output. Christen Sachse-Vasquez- csachsevasquez@
rifm.org can be contacted for recommendations or
additions to the query function or any other suggestions
for the RIFM Database.
Coming Attractions for the RIFM Database
Future plans for the RIFM Database include the capability
to conduct structure searching, additional regulatory
status information and the increased ability for members
to retrieve their own data directly via the web Database.
DocUniq
Another new feature developed by RIFM
staff is a program called DocUniq. The
program allows RIFM to store all material
references in a centralized location and
access them directly from the corresponding
RIFM Database material reference
pages. The program is currently in a pilot
test with a RIFM member company subscriber—testing
reference access to their
own company studies. Look for the expansion
of the program to additional RIFM Database
subscriber companies in 2012.
www.rifm.org rifm@rifm.org
2011 Annual Report
27

Communications
A New Web Site At www.rifm.org
In March of 2011, RIFM launched a
brand new web site with improved
navigation and visitor interactivity.
From the RIFM Science tab on the
home page, you will find pages that
are dedicated to each of RIFM’s scientific
disciplines. There are also
corresponding science pages in
the member area with richer content
for members. The science pages
enable the visitor to more easily find
information dedicated to a particular
scientific category (i.e. respiratory
or environmental, etc.). The
RIFM web site is also now integrated
with RIFM’s contact database which
provides more convenient web based
services to members, like secure
online registration for any of RIFM’s
educational offerings and a secure
member directory where member
company contacts can update their
own information or add themselves to
RIFM’s mailing list to stay current on
RIFM’s activities. Analytics show that
traffic on the RIFM web site, www.rifm.
org, has doubled since the launch of
the new site.
RIFM Registered Logo
The RIFM logo was registered and all materials were
updated with the new logo carrying the registration mark
to strengthen the RIFM
brand. This includes the
RIFM Member logo. For updated
versions of the RIFM
or RIFM Member registered
logos for your company
use, e-mail rifm@rifm.org.
RIFM PR Program
RIFM continues to promote its activities through
e-mail bulletins, the RIFM web site, RIFM’s social
media sites— LinkedIn, Twitter, Facebook, YouTube—
and through a growing PR program. This year 20 press
releases were issued with global coverage through
PR Newswire and our own growing network. RIFM
scientific advancements in fragrance safety are now hitting
all the major web news portals, social media sites,
television networks, news and trade publications. All
of RIFM’s press releases are available by year from the
News and Events section of the web site
28 21st Century Pathways and People www.rifm.org rifm@rifm.org

Member Services
New Member
RIFM welcomed Berje, Inc., Carteret, New Jersey, USA
to membership in 2011. Berje is a global distributor of essential
oils and aromatic fragrance materials.
Member Information Management
With the launch of the new web site, RIFM completed
its conversion to Avectra NetForumPro association
management software to provide members with
instant web access to membership benefits, including:
the RIFM Online Store, a searchable and secure membership
directory, event registration and downloadable
publications. These features seamlessly integrate with
the www.rifm.org web page to provide an optimal user
experience.
Member Interactions
RIFM staff visited and made informational presentations
on the RIFM program at L’Oreal and Johnson &
Johnson. If you would like RIFM staff to present the
program and recent study results at your company or for
anything else member related, e-mail Lauren Dunleavy,
Member Services Manager, ldunleavy@rifm.org.
Social Media
RIFM members and followers are reading the latest industry
news, features and science updates through social
media. RIFM is on Twitter, Facebook, LinkedIn, You-
Tube, and Pinterest. On LinkedIn, RIFM started a new
group “RIFM Safe Use of Fragrance Materials Discussion
Group” where industry leaders and insiders carry on topical
conversations with their peers.
RIFM Member Benefits
RIFM member company contacts can take advantage of the many benefits of RIFM membership:
• Discounted RIFM Database access
• Discounted or free Letters of Access (LoAs) for RIFM funded studies
• Discounted or free event registrations, including webinars
• Discounted or free group summaries and reprints
of recent RIFM study publications
RIFM webinars continue to be some of the most
popular educational offerings across all of the
scientific disciplines and are often free to
RIFM member company staff. They cover
the most up to date information on alternative
methods and models and the
most recent results of RIFM research
and safety evaluations. And, if you
missed one, a recording is often
available from the Events Archive
of the RIFM web site at www.rifm.org.
www.rifm.org rifm@rifm.org
2011 Annual Report
29

The RIFM Staff
Ladd W. Smith, Ph.D., Dipl. ABT, Fellow ATS, CAE
President
Human Health Science
Anne Marie Api, PhD
Vice President,
Human Health Science
Valerie Politano, PhD
Human Health Specialist
Jon Lalko
Human Health Researcher
Gretchen Ritacco
Technical Writing Coordinator
Charlene Letizia
Manager, Technical Writing
Sneha Bhatia
Senior Technical Writer
Danielle McGinty
Technical Writer
Joseph Scognamiglio
Technical Writer
Environmental Science
Daniel T. Salvito, PhD.
Vice President,
Environmental Science
Aurelia Lapczynski
Environmental Specialist
Iain Davies
Environmental Scientist
30 21st Century Pathways and People www.rifm.org rifm@rifm.org

Respiratory Science
Communications
Madhuri Singal, PhD, RRT
Manager, Respiratory Science
Danielle Vitale
Respiratory Specialist
Marie Gartshore
Communications Manager
The RIFM Database Group
Member Services
Christen Sachse-Vasquez
Director, Technical Information
and Services
Dino Pfund
Database Developer/
Programmer
Lauren Dunleavy
Member Services Manager
Administration
Mary Mircovich
Specialist, Scientific Literature
Nancy Nowinski
Literature Specialist
June Moncalieri
Office Manager
Ellen Shapiro
Accountant
Cinthujaa Sivanantha
Data Project Specialist
Cathy Juliano
Administrative Assistant
www.rifm.org rifm@rifm.org
2011 Annual Report
31

The RIFM member logo is a symbol of integrity that stands for the most extensive program, anywhere
in the world, for testing and evaluating fragrance raw materials. A symbol of integrity dedicated to
the safety of fragrance ingredients, RIFM research is supported by industry and evaluated by an
independent panel of international experts in toxicology and dermatology. Implicit in the member
companies’ support of the Institute is their commitment to be guided by its research findings.
Active Members
Agilex Flavors & Fragrances, Inc.
Alpha Aromatics, L.P.
Alpine Aromatics International, Inc.
Arylessence, Inc.
BASF Corporation
Bedoukian Research, Inc.
Bell Flavors & Fragrances, Inc.
Belmay, Inc.
Berje, Inc.
Capua S.r.l.
Carrubba, Inc.
Charabot & Co., Inc.
Chemia Corporation
Citrus & Allied Essences Ltd.
Continental Aromatics
Cosmo International Fragrances Corporation
CPL Aromas
Custom Essence, Inc.
drom fragrance GmbH & Co. KG
Elias Fragrances, Inc.
Flavor and Fragrance Specialties
Fragrance Design, LLC
Fragrance Resources, Inc.
French Color and Fragrance Co., Inc.
French-Korean Aromatics
Consumer Product Active Members
Chanel S.A.S.
L’Oreal
SC Johnson & Son, Inc.
Supporting Members
Alberto-Culver Company
Avon Products, Inc.
Beauty Avenues
Colgate-Palmolive Company
Coty, Inc.
Johnson & Johnson Consumer Companies, Inc.
Kimberly-Clark Corporation
Associate Members
Cadima Pathe
Huber Research
IFRA Members
Firmenich, Inc.
International Flavors & Fragrances, Inc.
Givaudan S. A.
Grau Aromatics GmbH & Co. KG
Intarome Fragrance Corp.
International Aromatics, Inc.
J & E Sozio, Inc.
Kao Corporation
Kerry Group plc
Kimex Co., Ltd.
LyondellBasell Flavors and Fragrances, LLC
Mane, USA
Medallion International, Inc.
Monarch Fragrances, LLC
Ogawa & Co., Ltd.
Organica Aromatics
Oriental Aromatics, Inc.
PFW Aroma Chemicals, B.V.
PT Indesso Aroma
Soda Aromatic Co., Ltd.
Synarome-Nactis U.S., Inc.
T. Hasegawa Co., Ltd.
Tennants Fine Chemicals, Ltd.
The Lebermuth Company, Inc.
Ultra International Limited
Ungerer & Company
Yinghai (Cangzhou) Aroma Chemical Co. Ltd.
The Proctor & Gamble Company
Unilever
Natura Inovacao e Technologia de Produtos Ltd
Parfums Christian Dior
Pola Chemical Industries Inc.
Reckitt Benckiser Healthcare (UK) Ltd
Sally Beauty Supply LLC.
Shiseido Co. Ltd.
The Estee Lauder Companies, Inc.
Yves Rocher
Robertet S. A.
Symrise GmbH & Co. KG
Takasago International Corp.
32 21st Century Pathways and People www.rifm.org rifm@rifm.org

www.rifm.org rifm@rifm.org
2011 Annual Report
33

Research Institute for Fragrance Materials, Inc.
50 Tice Boulevard, Woodcliff Lake, NJ 07677 USA
Tel: 1.201.689.8089 Fax: 1.201.689.8090
www.rifm.org e-mail: rifm@rifm.org
34 21st Century Pathways and People www.rifm.org rifm@rifm.org