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mitations Impacting Environmental Assessments

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QSAR Application<br />

Absent measured values QSARs and other<br />

models may be used to fill data gaps<br />

Concerns arise regarding the “fit” of the<br />

chemical under study to the model domain<br />

‣ Is the structure type adequately covered by<br />

the model?<br />

‣ Are there li<strong>mitations</strong> on physical-chemical<br />

chemical<br />

parameters?<br />

‣ What is the model’s s reliability?<br />

1 March 2007 CTFA Annual Meeting

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