Contrast-Enhanced MR Perfusion Imaging - University of Wisconsin ...
Contrast-Enhanced MR Perfusion Imaging - University of Wisconsin ... Contrast-Enhanced MR Perfusion Imaging - University of Wisconsin ...
↑ CBV Predicts Glioma Transformation Post Radiation Necrosis : Low CBV Baseline 6 months 18 months Danchaivijitr et al Radiology 2008; 247: 170-178 CBV Estimation in Tumors Gadolinium Preload Reduces Model Dependence UTI CTI GV PBSI MSD NEI Metastatic Breast Carcinoma (HER-2 +) Without preload CT- MTT CBF With preload Paulson and Schmainda Radiology 2008; 249:601 CT+ CBV Permeability Elevated Permeability in Acute Ischemic Stroke Perfusion Summary CT CTA MTT CBF 1 2 3 1 2 3 CBV KPS 1 2 3 1 2 3 • Perfusion Methods –Dynamic Susceptibility Contrast – T2* –Dynamic Contrast Enhancement – T1 –Arterial Spin Labeling - Tag • Key Parameters –Cerebral Blood Flow –Cerebral Blood Volume –Mean Transit Time • Applications –Stroke and Tumors
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↑ CBV Predicts Glioma Transformation<br />
Post Radiation Necrosis : Low CBV<br />
Baseline 6 months 18 months<br />
Danchaivijitr et al Radiology 2008; 247: 170-178<br />
CBV Estimation in Tumors<br />
Gadolinium Preload Reduces Model Dependence<br />
UTI CTI GV PBSI MSD NEI<br />
Metastatic Breast Carcinoma (HER-2 +)<br />
Without preload<br />
CT-<br />
MTT<br />
CBF<br />
With preload<br />
Paulson and Schmainda Radiology 2008; 249:601<br />
CT+ CBV Permeability<br />
Elevated Permeability in Acute Ischemic Stroke<br />
<strong>Perfusion</strong> Summary<br />
CT<br />
CTA<br />
MTT<br />
CBF<br />
1<br />
2<br />
3<br />
1<br />
2<br />
3<br />
CBV<br />
KPS<br />
1<br />
2<br />
3<br />
1<br />
2<br />
3<br />
• <strong>Perfusion</strong> Methods<br />
–Dynamic Susceptibility <strong>Contrast</strong> – T2*<br />
–Dynamic <strong>Contrast</strong> Enhancement – T1<br />
–Arterial Spin Labeling - Tag<br />
• Key Parameters<br />
–Cerebral Blood Flow<br />
–Cerebral Blood Volume<br />
–Mean Transit Time<br />
• Applications<br />
–Stroke and Tumors
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