Neuroimaging Christopher Bever, MD, MBA (MODERATOR) Use of ...

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MRI in MS Clinical Trials and Natural History Studies Interferon dosing Natural History Data From Li et al From Fisniku et al Question - The Relevance <strong>of</strong> Population Studies to the Individual ?
FROM SIMPLE TO COMPLEX T2-Lesions Gd-Enhancing Lesions T1-Black Holes Atrophy Magnetization Transfer Diffusion Tensor Myelin Water Functional MRI MR Spectroscopy •Long Experience, Validated - Secondary Measures in Trials •Increasing Relevance to Care <strong>of</strong> the Individual Patient
Page 1 and 2: Neuroimaging Christopher Bever, MD,
Page 3 and 4: Disclaimer • The speaker has rece
Page 5: MRI in the Individual Patient (As O
Page 9 and 10: Gadolinium Enhancing Lesions Cell T
Page 11 and 12: T2 Lesions Non-Specific Pathology I
Page 13 and 14: Distribution--Periventricular >> Pe
Page 15 and 16: T1 “Black Holes” A subset of T2
Page 17 and 18: Spinal Cord Proton/T2 Proton densit
Page 19 and 20: Number Lesions Most of the Disease
Page 21 and 22: MRI in Diagnostic Criteria
Page 23 and 24: Accurate Prediction of Earliest MS
Page 25 and 26: Barkoff Combined Criteria More Accu
Page 27 and 28: McDonald Criteria Annals of Neurolo
Page 29 and 30: Earlier Diagnosis of MS with MRI Ev
Page 31 and 32: The Criteria are Imperfect - Vigila
Page 33: Both criteria highly specific (>90%
Page 36 and 37: 2003 Cortical Lesions only in retro
Page 38 and 39: Okuda et al. Neurology 2009;72:800
Page 40 and 41: Use of MRI to Follow Subclinical Di
Page 42 and 43: 1 4 7 10 13 16 19 22 25 28 37 40 43
Page 44 and 45: Use of MRI to Determine Treatment R
Page 46 and 47: Evaluating the Therapeutic Response
Page 48 and 49: Two year follow-up ; Outcome = Disa
Page 50 and 51: Treated Patients with 2 or more les
Page 52 and 53: New atypical weakness or seizure In
Page 54 and 55: PML Concern is Detecting PML +MS
Page 56 and 57:
Yousry et al. NEJM;2006 354:924-933
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Standardized MRI For Improved Care
Page 61 and 62:
Standardized MRI Guidelines PD opti
Page 63 and 64:
Update T. Traboulsee et al In 2009
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Field Strength Matters Sicotte, 200
Page 67 and 68:
We Expect 3D Acquisitions to become
Page 69 and 70:
3D FLAIR - 1mm partitions reconstru
Page 71 and 72:
MRI Signal and Field Strength 3T sc
Page 73 and 74:
7T MS MPRAGE 0.8 mm thick AIRC at O
Page 75 and 76:
MS, Fe Permeability Study OHSU 7T,
Page 77 and 78:
Summary- And Learning • Classical
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Neuroimaging Christopher Bever, MD, MBA (MODERATOR) Use of ...

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