F&N Bulletin Vol 23 No 1b - United Nations University
F&N Bulletin Vol 23 No 1b - United Nations University
F&N Bulletin Vol 23 No 1b - United Nations University
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Iron and energy supplementation<br />
The AED group had a daily energy balance of –498<br />
kcal before iron supplementation, –457 kcal after<br />
iron supplementation, and 48 kcal after iron–energy<br />
supplementation. There was a significant (p < .01)<br />
difference in the daily energy balance after iron–energy<br />
supplementation (table 4).<br />
Blood iron indices<br />
The values for hemoglobin, serum iron, total ironbinding<br />
capacity (TIBC), and transferrin saturation<br />
(TS) of AEA and AED subjects are given in table 5.<br />
Hemoglobin, serum iron, and TS increased significantly<br />
(p < .01) after iron supplementation, whereas<br />
TIBC showed a significant (p < .01) decline after the<br />
supplementation. It took 6 to 9 months to bring the<br />
hemoglobin level of anemic subjects to 12 g/dl.<br />
Treadmill test<br />
Exercise time and maximum work load on the treadmill<br />
increased significantly (p < .01) after iron supplementation<br />
and after iron–energy supplementation<br />
in both groups (table 6), indicating improved physical<br />
61<br />
fitness after iron supplementation and still better<br />
physical fitness after iron–energy supplementation.<br />
Edgerton et al. [35] and Gopaldas and Seshadri [36]<br />
reported an improvement in physical fitness with an<br />
increase in hemoglobin level. Rowland et al. [37] also<br />
reported that the treadmill endurance time improved<br />
significantly with iron supplementation. The minimal<br />
level for maximal work load to estimate physical fitness<br />
is 11 MET. The AEA group before and after iron supplementation,<br />
and the AED group after iron–energy<br />
supplementation, had an exercise capacity above the<br />
minimal level of fitness, i.e., 11 MET. However, before<br />
supplementation, the treadmill exercise capacity of the<br />
AED group was below the fitness level, which means<br />
that with both energy and iron deficiency the fitness<br />
level was unsatisfactory, but after supplementation<br />
there was a satisfactory improvement in fitness in<br />
both groups. There was no significant change in initial<br />
systolic blood pressure of either group after iron and<br />
iron–energy supplementation. Similarly, there was no<br />
significant difference in postexercise systolic blood<br />
pressure before and after supplementation. However,<br />
the subjects were able to exercise for a longer time<br />
after iron supplementation.<br />
TABLE 4. Energy intake, basal metabolic rate, energy expenditure, and energy balance of subjects in the anemic but<br />
energy-adequate (AEA) and the anemic and energy-deficient (AED) groups a<br />
AEA<br />
AED<br />
Before iron After iron Before iron After iron After iron–<br />
supplemen- supplemen- supplemen- supplemen- energy supple- p value<br />
Value (kcal/24 h) tation (a) tation (b) tation (c) tation (d) mentation (e) (c vs e)<br />
Energy intake 1,966 ± 22 1,989 ± 26 1,334 ± 32 1,351 ± 31 1,932 ± 12 < .01<br />
Basal metabolic rate 1,353 ± 12 1,352 ± 12 1,284 ± 70 1,286 ± 8 1,324 ± 60 < .01<br />
Energy expenditure 1,926 ± 38 1,932 ± 39 1,831 ± 28 1,808 ± 28 1,885 ± 28 NS<br />
Energy balance 40 ± 33 57 ± 34 –498 ± 43 –457 ± 37 48 ± 18 < .01<br />
a. Values are means ± SE. NS, <strong>No</strong>nsignificant. Differences between a and b and between c and d are nonsignificant for all nutrients.<br />
TABLE 5. Blood iron status of subjects in the anemic but energy-adequate (AEA) and the anemic and energy-deficient<br />
(AED) groups (n = 15) a AEA AED<br />
Before iron After iron Before iron After iron After iron–<br />
supplemen- supplemen- t value supplemen- supplemen- energy supplep<br />
value<br />
Blood value b tation (a) tation (b) (a vs b) tation (c) tation (d) mentation (e) (c vs d) (c vs e)<br />
Hb (g/dl) 7.7 ± 0.2 12.2 ± 0.06 22.61** 7.4 ± 0.1 12.1 ± 0.05 12.1 ± 0.7 < .01 < .01<br />
Serum iron 51.3 ± 2.8 94.6 ± 6.1 6.69** 51.6 ± 3.0 90.4 ± 4.0 93.1 ± 4.2 < .01 < .01<br />
(µg/100 ml)<br />
TIBC (µg/100 ml) 577 ± 13.7 332 ± 9.1 15.46** 554 ± 18.3 339 ± 12.1 349 ± 10.8 < .01 < .01<br />
Unsaturated iron- 525 ± 16.2 <strong>23</strong>7 ± 13.6 14.13** 502 ± 21.0 248 ± 11.8 256 ± 14.2 < .01 < .01<br />
binding capacity<br />
(µg/100 ml)<br />
TS (%) 9.2 ± 0.8 29.0 ± 2.2 8.88** 9.8 ± 1.0 27.2 ± 1.6 27.4 ± 1.8 < .01 < .01<br />
a. Values are means ± SE. Hb, Hemoglobin; TIBC, total iron-binding capacity; TS, transferrin saturation.<br />
b. The normal values are Hb, 12 g/dl [25]; serum iron, 63–202 µg/100 ml [33]; TIBC, 250–416 µg/100 ml [34]; unsaturated iron-binding<br />
capacity, 0–500 µg/100 ml [22]; and TS, 16%–37% [<strong>23</strong>].<br />
**p < .01.