PHX WNL QA_13April20.. - Pharsight

Q: When import the data from out exls. how to delete the unnecessary information and how to match
the form WNL required?
The import Wizard in Phoenix allows you to indicate the rows to import from an Excel file. I will attach
the phoenix project that was partially shown in the webinar if you want to see some additional details.
You will need to have Phoenix WinNonlin installed even if you don’t have license.
Q: What does Pharsight recommend as calculation estimation: linear up/log down, or other?
I (Ana) can only speak for myself but my opinion is that if you had to pick a default estimation the best
would be the general linear up/log down because it accounts for several bumps on the data and also for
log-estimation on the decay part of the curve which is especially important if the data are considerably
spread out. However, with rich datasets when the data was collected relatively close to each other the
4 methods will give you very similar results and one should just document what was use for
reproducibility but I doubt it would change any major conclusion.
Q: Why does my version number show as 1.0 on my NCA core output? Our QA Dept. is complaining
that it used to be there and is not anymore!
The core output for NCA still shows the core version number 1.0 (right at the beginning). This version
applies to the NCA analysis engine (the “core”), which is unchanged since 2007. The NCA engine is one
of many analysis engines implemented in WNL/PHX WNL. The NCA user interface has changed but the
engines behind it are stable and remain the same. See screenshot
However, we realize that this could be confusing so we have entered a defect to make sure that the
version of the software is shown in this output in the future.
Q: 半 衰 期 是 采 用 消 除 相 的 3 个 点 做 的 吗 ?Google Translation: ‘Elimination phase half-life is the use
of 3 points to do?’