Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
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How Can We Evaluate ?<br />
• Assumption Checking<br />
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Randomization tests for the p-values<br />
Graphics for distributional assumptions (Residuals, empirical Bayesian estimates, …)<br />
• Stability/precision of parameter estimates<br />
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Validation through parameter prediction errors<br />
Log-Likelihood Profile<br />
Bootstrap (parametric & non-parametric)<br />
Cross-Validation/Leverage analysis<br />
• Assessment of model performance/properties<br />
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Prediction errors (from internal or external test set)<br />
Posterior Predictive Check/ Predictive Check/ Visual / Numerical / Quantitative<br />
Sensitivity Analysis<br />
Karlsson et al. Assumption testing in population pharmacokinetic models: illustrated with an<br />
analysis of moxonidine data from congestive heart failure patients. J PK B 26(2):207-46 1998.<br />
EI Ette. <strong>Population</strong> <strong>Mode</strong>l Stability and Performance. J Clin Pharmacol 37:486-495 (1997).<br />
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