Population PKPD Mode.. - Pharsight Corporation

What Can We Evaluate ?
• The different parts of the model
– Structural PK-PD model
– Covariate-parameter relationships models
– Random effect models
- Residual variability model
• The performance of model-based inferences
– Parameter estimates & confidence intervals
– Hypothesis tests
• Explore the data (EDA)
• Follow the objectives
• Keep the model plausible
• Understand and check the
assumptions and limitations
• Define useful decision making
criteria
•Diagnosis can include a set of
plausible models
– Predictions/simulations with model
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