Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
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Summary of <strong>Mode</strong>l building<br />
Absorption <strong>Mode</strong>l<br />
Disposition <strong>Mode</strong>l<br />
⎡θ1<br />
⎤<br />
⎢<br />
θ<br />
⎥<br />
Θ= ⎢<br />
2 ⎥<br />
⎢⎣<br />
θ ⎥<br />
3 ⎦<br />
Deterministic<br />
Component<br />
⎡Ω11<br />
Ω=<br />
⎢<br />
⎢<br />
Ω Ω<br />
⎢⎣<br />
0 0<br />
12 22<br />
⎡σ<br />
Ω<br />
33<br />
⎤<br />
⎥<br />
⎥<br />
⎥⎦<br />
⎤<br />
11<br />
Σ= ⎢<br />
0 σ ⎥<br />
22<br />
⎣<br />
Between subject variability Matrix<br />
⎦<br />
Residual error model<br />
Stochastic<br />
Component<br />
Covariate <strong>Mode</strong>l Building<br />
Base <strong>Mode</strong>l<br />
Final <strong>Mode</strong>l<br />
With Covariates<br />
<strong>Mode</strong>l Evaluation<br />
slide 40<br />
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