Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Typical POP PK <strong>Mode</strong>l Development Workflow<br />
Developing a Covariate <strong>Mode</strong>l : Backward Elimination<br />
Covariate <strong>Mode</strong>l Building<br />
Backward Deletion<br />
Remove covariates<br />
one by one by reverse order :<br />
Weight and Sex on Vd<br />
Weight, Sex, CRCL on CL<br />
Repeat until no<br />
covariate can be<br />
removed<br />
Proceed with <strong>Mode</strong>l<br />
Validation and Evaluation<br />
Final <strong>Mode</strong>l<br />
Tentative Final <strong>Mode</strong>l<br />
With Covariates<br />
slide 37<br />
© <strong>Pharsight</strong> <strong>Corporation</strong> All Rights Reserved
Change language