Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
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Typical POP PK <strong>Mode</strong>l Development Workflow<br />
Developing a Covariate <strong>Mode</strong>l : Stepwise <strong>Mode</strong>l Building<br />
Proceed with next step<br />
of covariate addition<br />
Important Covariates (GAM)<br />
Forward Stepwise Addition<br />
Graphs of WRES/CWRES and etas<br />
vs<br />
Covariates : Weight, Sex, CRCL<br />
Repeat until no<br />
covariate Covariate is <strong>Mode</strong>l significant Building<br />
Tentative <strong>Mode</strong>l<br />
With Covariates<br />
or<br />
Test each on PK parameters<br />
one by one :<br />
Weight and Sex on Vd<br />
Weight, Sex, CRCL on CL<br />
Keep the most<br />
Significant<br />
Base <strong>Mode</strong>l<br />
<strong>Mode</strong>l + Covariate<br />
slide 36<br />
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