Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
Population PKPD Mode.. - Pharsight Corporation
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PK/PD Expertise in Early Drug Development<br />
2) IVIVC analysis using WinNonlin ® Toolkit to Perform Efficient Analyses<br />
● Modified-release formulations & super generics [505(b)2]<br />
● Fixed-Dose Combination Products<br />
● Drug Delivery systems (Transdermal, parenteral, microsphere, liposomes)<br />
Correlation<br />
1<br />
Cp (ug/ml)<br />
1.2<br />
0.6<br />
0<br />
0 30 60<br />
time (hr)<br />
In Vivo Release (%)<br />
Fastest<br />
Fast<br />
0<br />
Medium<br />
Slow 0 0.5 1<br />
In Vitro Release (%)<br />
0.5<br />
Percent Dissolved<br />
100%<br />
50%<br />
0<br />
Fastest<br />
Fast<br />
Medium<br />
Slow<br />
0 150 300<br />
time (min)<br />
In Vivo<br />
In Vitro<br />
slide 15<br />
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