Phoenix FAQ: - Pharsight

March 2012
Phoenix® WinNonlin®
Frequently Asked Questions (FAQ)
Phoenix WinNonlin Questions
Q:What is Phoenix WinNonlin?
Phoenix WinNonlin is the next generation of WinNonlin, the industry standard for PK and PO
modeling and noncompartmental analysis. Phoenix WinNonlin improves the scientific
productivity of critical drug development tasks by providing a comprehensive analysis
environment that implements efficient, reusable workflows,and high quality outputs while
reducing learning and collaboration barriers and enabling more impactful quantitative
decision making. Phoenix is an evolution of WinNonlin and a revolution in modeling.
Q: Why would I want Phoenix WinNonlin?
A: Phoenix WinNonlin is an easy to learn comprehensive analysis environment where you
can perform virtually all of the analyses for standard PK and PK/PD studies. It facilitates
decision making by easily generating figures, tables and listings for standard PK and PK/PD
studies. It allows you to analyze multiple matrices (e.g., urine, plasma) in a single NCA run.
Phoenix WinNonlin provides large gains in efficiency by enabling you to build analyses in an
intuitive workflow schematic that can be copied, reused, and shared with colleagues. You can
make changes to the workflow and refresh it without rebuilding the whole analysis project.
Quality auditors can view the workflows and settings to easily verify outputs.
Phoenix WinNonlin allows for multiple simultaneous models in a given project (workspace),
unlike current versions of WinNonlin. Phoenix' high-quality graphics reduce your reliance on
outside applications. All work is mapped in a visual workflow engine enabling more efficient
project management, modification, and error identification.
Phoenix WinNonlin allows you to process data with built-in routines for: sorting; merging;
filtering; stacking; pivoting; joining; and more. Integrated tables provide a quick and
easy way to tabulate data while allowing the flexibility to edit in Microsoft® Excel.
Phoenix WinNonlin is easy to learn and promotes collaboration through easily transferable
project files and templated workflows and models.
When used with Phoenix Connect (sold separately), you can access the Pharsight®
Knowledgebase Server (PKS) as well as third party solutions and standards including:
CDISC, SAS, S-Pius®,R ®, NONMEM®, PsN, SigmaPiot®,and ODBC.
© 2012 Certara, L.P. All Rights Reserved
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Q: What happened to WinNonlin®?
A: WinNonlin is still Pharsight's flagship product. Phoenix WinNonlin is implemented on
the Phoenix platform and has a much improved look and feel. Phoenix WinNonlin has the
same computational engines in place and can load most files and workspaces from
WinNonlin versions 5 and 4. Support for WinNonlin without Phoenix will be eventually
discontinued. Contact Pharsight at support@pharsight.com for exact support
termination dates for a given WinNonlin version.
Q: Would I get the same answers in Phoenix WinNonlin as WinNonlin 5?
You will get the same answers when running analyses in Phoenix WinNonlin as you did
with WinNonlin 5.3, unless specific enhancements have been added that could affect the
results. For example, the best fit algorithm in the NCA module has been enhanced
whereby Cmax
values are never included in the lambdaz regression. In such case the results might differ
with the best fit algorithm but if the user manually enters the same start and end point for
lambdaz calculation then results will be exactly the same. These type of expected migration
issues are documented in the release notes of each version.
Q: I already have an earlier WinNonlin version, what is my upgrade path?
A: The latest available version of Phoenix WinNonlin is the upgrade path and is free of
charge if you have an existing license agreement and have paid your annual license
fee.
Q: What backwards compatibility exists with files created using previous versions of
WinNonlin?
A: Phoenix WinNonlin (PHX WNL) 32-bit can read most files created with previous versions of
WinNonlin (WNL), but it will not write to those file types.
Files/formats Import & Save in Export
New Format
WNL- PWO,PMO, PCO, PTO Yes No
WNL- tools setting files e.g. lml Yes No
WNL- ASCII models Yes No
WNL- User Compiled models No No
WNL- command files Yes No
If you have a WNL node license, you will be able to run WinNonlin 5 OR Phoenix
WinNonlin 6 at the same time. You will need to request this dual license at time of
renewal.
If you have a WinNonlin float license, you can run both simultaneously as long as two
licenses are available. Each running WinNonlin application will use (or check out I tie up)
one available float license.

Q: How are project files stored in Phoenix WinNonlin?
A:, Phoenix WinNonlin captures all relevant information related to an analysis or
model and saves it in a single project file, *.phxproj, that can be easily located and
shared. In other words, a Phoenix project will store all input data, all data analysis
and all results. In addition, one can import files for storage within the project like a
Microsoft Word or Power Point document. These files cannot be read directly from
Phoenix but they are stored within the project and can be exported and viewed
after the project is loaded.
Q: What about the IVIVC Toolkit for WinNonlin?
A: With Phoenix WinNonlin 6.2, a new Phoenix IVIVC Toolkit for WinNonlin is
available. The previous toolkit for the non-Phoenix version has been incorporated
into Phoenix. In addition, several enhancements to the toolkit were performed.
Existing IVIVC Toolkit for WinNonlin customers who are current under an Annual
License Fee can upgrade at no additional cost.
Q: What is the compatibility of Phoenix WinNonlin AutoPilot and PKS?
A: Phoenix WinNonlin is compatible with PKS 4 versions. A new AutoPilot 2.0 Toolkit for
Phoenix was introduced in Phoenix 1.2.1. This toolkit will continue to be updated with each
new release of Phoenix.
Q: Is there a Validation Suite for Phoenix WinNonlin 6.3?
A: The Phoenix Validation suite for Phoenix WinNonlin 6.3 (Phoenix WinNonlin Validation
Suite 2.2) will be available shortly following the release of Phoenix WinNonlin 6.3.
Validation Suite products support validation activities for Pharsight's products through
execution of automated test scripts and documentation templates. It is based on a
commercial test automation product that is used to execute test scripts delivered in
packages for the different products and also allows for user-developed test scripts.
Therefore, Phoenix WinNonlin Validation Suite 2.2 will contain all the necessary scripts to
automatically validate most of the Phoenix WinNonlin functionality. The tool comes with
several documents explaining the requirements that each script automates.
Q:Can Phoenix WinNonlin 6.3 run on Windows7 (64-bit edition)?
A: Phoenix WinNonlin 6.3 has been certified on Windows 7 (32-bit and 64-bit edition).
Specifically Phoenix WinNonlin 6.3 supports Windows 7 SP1 (32- and 64-bit)- English
(United States), Kanji (Japan), French (France),Spanish (Spain),German (Germany),
Simplified Chinese (China).
Q: How can I obtain additional information on Phoenix WinNonlin?
A: Technical support:
Consult the product documentation to address questions. If further assistance is needed, contact
Pharsight technical support through e-mail, our web site, phone, fax, or mail.
E-mail: support@pharsight.com (fastest response time)
Web: http://www.pharsight.com/support/support_home.php
Phone: 1-919-852-4620
User Forum
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