Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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1979: A Rebirth<br />
Lewis She<strong>in</strong>er <strong>and</strong> coworkers made Segre’s model more popular. They<br />
were the first to formalize this concept <strong>in</strong>to a model to describe<br />
hysteresis caused by distribution to the biophase.<br />
It was reborn as the ―L<strong>in</strong>k Model‖:<br />
Cp<br />
Effect<br />
Effect<br />
HYSTERESIS LOOP<br />
Time<br />
Time<br />
Cp<br />
Ce<br />
EQUILIBRIUM KINETICS<br />
Effect<br />
Effect<br />
DIRECT RELATIONSHIP<br />
Time<br />
Time<br />
Ce<br />
She<strong>in</strong>er LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous model<strong>in</strong>g <strong>of</strong> pharmacok<strong>in</strong>etics <strong>and</strong> pharmacodynamics:<br />
application to d-tubocurar<strong>in</strong>e. Cl<strong>in</strong> Pharmacol Ther. 1979 Mar;25(3):358-71.<br />
Slide 7<br />
© Tripos, L.P. 2011 All Rights Reserved
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