Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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A Brief History of PK/PD THE LATE 70’S: A REBIRTH Slide 6 © Tripos, L.P. 2011 All Rights Reserved
1979: A Rebirth Lewis Sheiner and coworkers made Segre’s model more popular. They were the first to formalize this concept into a model to describe hysteresis caused by distribution to the biophase. It was reborn as the ―Link Model‖: Cp Effect Effect HYSTERESIS LOOP Time Time Cp Ce EQUILIBRIUM KINETICS Effect Effect DIRECT RELATIONSHIP Time Time Ce Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther. 1979 Mar;25(3):358-71. Slide 7 © Tripos, L.P. 2011 All Rights Reserved
Page 1 and 2: Role of PKPD Modeling and Simulatio
Page 3 and 4: A Brief History of PK/PD THE LATE 6
Page 5: 1968: Was it a Premature Birth? •
Page 9 and 10: 80’s: Toddling Growing use of PK/
Page 11 and 12: A Brief History of PK/PD THE 90’S
Page 13 and 14: 90’s: The Advent of Mechanism-Bas
Page 15 and 16: A Brief History of PK/PD PK/PD TODA
Page 17 and 18: PK/PD has Matured Technically…
Page 19 and 20: ROLE OF PK/PD MODELING AND SIMULATI
Page 21 and 22: Case Study 1: Transitioning from Pr
Page 23 and 24: Event Probability (%) 0 10 20 30 40
Page 25 and 26: Case Study 1: Transitioning from Pr
Page 27 and 28: Case Study 2 — Step 1: Model Diab
Page 29 and 30: Case Study 2 —Step 3: Match entry
Page 31 and 32: PERSPECTIVES Slide 31 © Tripos, L.
Page 33 and 34: Perspectives • … as well as reg
Page 35 and 36: Acknowledgements • Pharsight coll

Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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