Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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1968: The Birth of PK/PD • Presence of a delay between norepinephrine concentration-time profiles and the kinetics of pharmacological response, i.e. blood pressure-time data. • Gino Segre introduced the concept of a ―hypothetical effect compartment‖ to account for this delay. • This allowed an empirical description of timedissociated kinetics. Segre G. Kinetics of interaction between drugs and biological systems. Farmaco Sci. 1968 Oct;23(10):907-18. Slide 4 © Tripos, L.P. 2011 All Rights Reserved
1968: Was it a Premature Birth? • NONLIN software only introduced in a year later by Carl Metzler. • It was written in FORTRAN-66 programming language for mainframe computers. • Long gap of PK/PD publications until 1979 CM Metzler. A Users Manual for NONLIN. Technical Report 7297 69 7292 005. Upjohn Co., Kalamazoo, Michigan (1969). Slide 5 © Tripos, L.P. 2011 All Rights Reserved
Page 1 and 2: Role of PKPD Modeling and Simulatio
Page 3: A Brief History of PK/PD THE LATE 6
Page 7 and 8: 1979: A Rebirth Lewis Sheiner and c
Page 9 and 10: 80’s: Toddling Growing use of PK/
Page 11 and 12: A Brief History of PK/PD THE 90’S
Page 13 and 14: 90’s: The Advent of Mechanism-Bas
Page 15 and 16: A Brief History of PK/PD PK/PD TODA
Page 17 and 18: PK/PD has Matured Technically…
Page 19 and 20: ROLE OF PK/PD MODELING AND SIMULATI
Page 21 and 22: Case Study 1: Transitioning from Pr
Page 23 and 24: Event Probability (%) 0 10 20 30 40
Page 25 and 26: Case Study 1: Transitioning from Pr
Page 27 and 28: Case Study 2 — Step 1: Model Diab
Page 29 and 30: Case Study 2 —Step 3: Match entry
Page 31 and 32: PERSPECTIVES Slide 31 © Tripos, L.
Page 33 and 34: Perspectives • … as well as reg
Page 35 and 36: Acknowledgements • Pharsight coll

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