Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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1968: The Birth <strong>of</strong> PK/PD<br />
• Presence <strong>of</strong> a delay between norep<strong>in</strong>ephr<strong>in</strong>e<br />
concentration-time pr<strong>of</strong>iles <strong>and</strong> the k<strong>in</strong>etics <strong>of</strong><br />
pharmacological response, i.e. blood pressure-time<br />
data.<br />
• G<strong>in</strong>o Segre <strong>in</strong>troduced the concept <strong>of</strong> a ―hypothetical<br />
effect compartment‖ to account for this delay.<br />
• This allowed an empirical description <strong>of</strong> timedissociated<br />
k<strong>in</strong>etics.<br />
Segre G. K<strong>in</strong>etics <strong>of</strong> <strong>in</strong>teraction between drugs <strong>and</strong> biological systems. Farmaco Sci. 1968<br />
Oct;23(10):907-18.<br />
Slide 4<br />
© Tripos, L.P. 2011 All Rights Reserved
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