Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

More documents

Recommendations

Info

Case Study 2: Value Delivered Impact • Modeling strategy provided sponsor timely and compelling support for positive efficacy signal of in-licensing candidate, helping to secure $23 million financing round and advance compound to Phase IIb Extensions • Potential for models to be combined with Phase IIb data to support downstream trial design and program strategy decisions (e.g., making predictions about steady-state HbA1c) Slide 30 © Tripos, L.P. 2011 All Rights Reserved
PERSPECTIVES Slide 31 © Tripos, L.P. 2011 All Rights Reserved
Page 1 and 2: Role of PKPD Modeling and Simulatio
Page 3 and 4: A Brief History of PK/PD THE LATE 6
Page 5 and 6: 1968: Was it a Premature Birth? •
Page 7 and 8: 1979: A Rebirth Lewis Sheiner and c
Page 9 and 10: 80’s: Toddling Growing use of PK/
Page 11 and 12: A Brief History of PK/PD THE 90’S
Page 13 and 14: 90’s: The Advent of Mechanism-Bas
Page 15 and 16: A Brief History of PK/PD PK/PD TODA
Page 17 and 18: PK/PD has Matured Technically…
Page 19 and 20: ROLE OF PK/PD MODELING AND SIMULATI
Page 21 and 22: Case Study 1: Transitioning from Pr
Page 23 and 24: Event Probability (%) 0 10 20 30 40
Page 25 and 26: Case Study 1: Transitioning from Pr
Page 27 and 28: Case Study 2 — Step 1: Model Diab
Page 29: Case Study 2 —Step 3: Match entry
Page 33 and 34: Perspectives • … as well as reg
Page 35 and 36: Acknowledgements • Pharsight coll

Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?