Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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log(anti Xa)<br />
log(PT)<br />
Case Study 1: Transition<strong>in</strong>g from Precl<strong>in</strong>ical to FIH<br />
Time-courses <strong>of</strong> anti-FXa activity <strong>and</strong> PT were derived:<br />
F=0.045 F=0.09 F=0.18 F=0.5<br />
0 4 8 12 20<br />
F=0.045 F=0.09 F=0.18 F=0.5<br />
0 4 8 12 20<br />
40<br />
80<br />
160<br />
4<br />
40<br />
80<br />
160<br />
2<br />
2.0<br />
0<br />
1.5<br />
1.0<br />
-2<br />
0.5<br />
4<br />
5 10<br />
20<br />
-4<br />
5<br />
10<br />
20<br />
0.0<br />
2<br />
0<br />
-2<br />
-4<br />
2.0<br />
1.5<br />
1.0<br />
0.5<br />
0.0<br />
0 4 8 12 20<br />
0 4 8 12 20<br />
0 4 8 12 20<br />
0 4 8 12 20<br />
Time (Hr)<br />
Time (Hr)<br />
S Rohatagi et al., Model based development <strong>of</strong> a direct Factor Xa <strong>in</strong>hibitor, ACoP Meet<strong>in</strong>g, Tucson AZ, Mar 2008<br />
Slide 22<br />
© Tripos, L.P. 2011 All Rights Reserved
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