Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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PK/PD has Matured Technically…<br />
•Types <strong>of</strong> PD variables:<br />
• Cont<strong>in</strong>uous<br />
• Categorical<br />
• B<strong>in</strong>ary<br />
• Time to event<br />
•Phoenix® NLME: a Dedicated<br />
Technology Platform<br />
•Types <strong>of</strong> models:<br />
• Direct or l<strong>in</strong>k models<br />
• Indirect response models<br />
• PD Drug <strong>in</strong>teraction models<br />
• Closed-loop dynamic systems<br />
• Mechanistic models, e.g. TMDD<br />
• Basel<strong>in</strong>es with complex patterns<br />
• L<strong>in</strong>kage to decision analytic <strong>and</strong><br />
economic models<br />
Slide 17<br />
© Tripos, L.P. 2011 All Rights Reserved
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