Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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PK/PD Today: a Mature Discipline Since 2000, the number of published PK/PD models has increased dramatically, with slightly more papers in Q1 this year than in the whole year 2000. Source: Pubmed search on March 29 th , 2011 (Key-words: ―pharmacodynamic AND modeling‖) Slide 16 © Tripos, L.P. 2011 All Rights Reserved
PK/PD has Matured Technically… •Types of PD variables: • Continuous • Categorical • Binary • Time to event •Phoenix® NLME: a Dedicated Technology Platform •Types of models: • Direct or link models • Indirect response models • PD Drug interaction models • Closed-loop dynamic systems • Mechanistic models, e.g. TMDD • Baselines with complex patterns • Linkage to decision analytic and economic models Slide 17 © Tripos, L.P. 2011 All Rights Reserved
Page 1 and 2: Role of PKPD Modeling and Simulatio
Page 3 and 4: A Brief History of PK/PD THE LATE 6
Page 5 and 6: 1968: Was it a Premature Birth? •
Page 7 and 8: 1979: A Rebirth Lewis Sheiner and c
Page 9 and 10: 80’s: Toddling Growing use of PK/
Page 11 and 12: A Brief History of PK/PD THE 90’S
Page 13 and 14: 90’s: The Advent of Mechanism-Bas
Page 15: A Brief History of PK/PD PK/PD TODA
Page 19 and 20: ROLE OF PK/PD MODELING AND SIMULATI
Page 21 and 22: Case Study 1: Transitioning from Pr
Page 23 and 24: Event Probability (%) 0 10 20 30 40
Page 25 and 26: Case Study 1: Transitioning from Pr
Page 27 and 28: Case Study 2 — Step 1: Model Diab
Page 29 and 30: Case Study 2 —Step 3: Match entry
Page 31 and 32: PERSPECTIVES Slide 31 © Tripos, L.
Page 33 and 34: Perspectives • … as well as reg
Page 35 and 36: Acknowledgements • Pharsight coll

Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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