Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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90’s: The Advent of Mechanism-Based PK/PD 1990 Founding paper on IPR models by W Jusko First publication on CTS First publication in population PK/PD First PK/PD Symposium In Leiden, Netherlands 1992 First publication referring to ―mechanism-based PK/PD‖ 1993 NEUG renamed to PAGE 1995: IPR models in WinNonlin 1.x 1998 NONMEM V released Windows 98 2000 An EMEA guideline requires PK/PD models for the development of antibacterials Slide 14 © Tripos, L.P. 2011 All Rights Reserved
A Brief History of PK/PD PK/PD TODAY: A MATURE DISCIPLINE Slide 15 © Tripos, L.P. 2011 All Rights Reserved
Page 1 and 2: Role of PKPD Modeling and Simulatio
Page 3 and 4: A Brief History of PK/PD THE LATE 6
Page 5 and 6: 1968: Was it a Premature Birth? •
Page 7 and 8: 1979: A Rebirth Lewis Sheiner and c
Page 9 and 10: 80’s: Toddling Growing use of PK/
Page 11 and 12: A Brief History of PK/PD THE 90’S
Page 13: 90’s: The Advent of Mechanism-Bas
Page 17 and 18: PK/PD has Matured Technically…
Page 19 and 20: ROLE OF PK/PD MODELING AND SIMULATI
Page 21 and 22: Case Study 1: Transitioning from Pr
Page 23 and 24: Event Probability (%) 0 10 20 30 40
Page 25 and 26: Case Study 1: Transitioning from Pr
Page 27 and 28: Case Study 2 — Step 1: Model Diab
Page 29 and 30: Case Study 2 —Step 3: Match entry
Page 31 and 32: PERSPECTIVES Slide 31 © Tripos, L.
Page 33 and 34: Perspectives • … as well as reg
Page 35 and 36: Acknowledgements • Pharsight coll

Role of PKPD Modeling and Simulation in Influencing ... - Pharsight

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