Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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90’s: The Advent <strong>of</strong> Mechanism-Based PK/PD<br />
1990<br />
Found<strong>in</strong>g paper on<br />
IPR models by W Jusko<br />
First publication<br />
on CTS<br />
First publication <strong>in</strong><br />
population PK/PD<br />
First PK/PD Symposium<br />
In Leiden, Netherl<strong>and</strong>s<br />
1992<br />
First publication referr<strong>in</strong>g to<br />
―mechanism-based PK/PD‖<br />
1993<br />
NEUG<br />
renamed<br />
to PAGE<br />
1995: IPR models <strong>in</strong> W<strong>in</strong>Nonl<strong>in</strong> 1.x<br />
1998<br />
NONMEM V released<br />
W<strong>in</strong>dows 98<br />
2000<br />
An EMEA guidel<strong>in</strong>e<br />
requires PK/PD models for the<br />
development <strong>of</strong> antibacterials<br />
Slide 14<br />
© Tripos, L.P. 2011 All Rights Reserved
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