Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
Role of PKPD Modeling and Simulation in Influencing ... - Pharsight
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90’s: The Advent <strong>of</strong> Mechanism-Based PK/PD<br />
In so-called ―Indirect Physiological Response (IPR)<br />
models‖, the drug concentration is no longer related to<br />
the PD variable itself. Instead, it is assumed to modulate<br />
upstream <strong>and</strong>/ or downstream regulation mechanisms.<br />
k <strong>in</strong><br />
k <strong>in</strong><br />
PD VARIABLE<br />
Conc<br />
k out<br />
k out<br />
Conc<br />
Slide 12<br />
© Tripos, L.P. 2011 All Rights Reserved
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