Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

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Mark Cushman
123. M. Cushman, H.-M. He, J. A. Katzenellenbogen, R. K. Varma, E, Hamel, C. M. Lin, S.
Ram, and Y. P. Sachedeva, "Synthesis of Analogs of 2-Methoxyestradiol with Enhanced
Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth," J. Med. Chem.
40, 2323-2334 (1997).
124. M. Cushman, F. Mavandadi, K. Kugelbrey, and A. Bacher, "Design and Synthesis of
Ribitylaminouracils Bearing Fluorosulfonyl, Sulfonic Acid, and Carboxylic Acid
Functionality as Inhibitors of Lumazine Synthase," J. Org. Chem. 62, 8944-8947 (1997).
125. G. Kohlhagen, K. Paull, M. Cushman, P. Nagafuji, and Y. Pommier, "Protein-linked
DNA Strand Breaks Induced by NSC 314622, a Non-camptothecin Topoisomerase I
Poison," Mol. Pharmacol. 54, 50-58 (1998).
126. A. B. Argade, R. D. Haugwitz, R. Devraj, J. Kozlowski, P. E. Fanwick, and M. Cushman,
"Highly Efficient Diastereoselective Michael Addition of Various Thiols to (+)-Brefeldin
A," J. Org. Chem. 63, 273-278 (1998).
127. M. Cushman, F. Mavandadi, K. Kugelbrey, and A. Bacher, "Synthesis of 2,6-Dioxo-
(1H,3H)-9-N-ribitylpurine and 2,6-Dioxo-(1H,3H)-8-aza-9-N-ribitylpurine as Inhibitors
of Lumazine Synthase and Riboflavin Synthase," Bioorg. Med. Chem. 6, 409-415 (1998).
128. M. Cushman, A. Casimiro-Garcia, K. Williamson, and W. G. Rice, "Synthesis of a Nonnucleoside
Reverse Transcriptase Inhibitor in the Alkenyldiarylmethane (ADAM) Series
with Optimized Potency and Therapeutic Index," Bioorg. Med. Chem. Lett. 8, 195-198
(1998).
129. M. Cushman, S. Insaf, J. A. Ruell, C. A. Schaeffer, and W. G. Rice, "Synthesis of a
Cosalane Analog with an Extended Polyanionic Pharmacophore Conferring Enhanced
Potency as an Anti-HIV Agent," Bioorg. Med. Chem. Lett. 8, 833-836 (1998).
130. M. Cushman, A. Casimiro-Garcia, E. Hejchman, J. A. Ruell, M. Huang, C. A. Schaeffer,
K. Williamson, W. G. Rice, and R. W. Buckheit, Jr. "New Alkenyldiarylmethanes
(ADAMs) with Enhanced Potencies as Anti-HIV Agents Which Act as Non-Nucleoside
Reverse Transcriptase Inhibitors," J. Med. Chem. 41, 2076-2089 (1998).
131. M. Jayaraman, P. E. Fanwick, and M. Cushman, "Novel Oxidative Transformation of
Indenoisoquinolines to Isoquinoline-3-spiro-3'-phthalides in the Presence of Osmium
Tetroxide and 4-Methylmorpholine N-Oxide," J. Org. Chem. 63, 5736-5737 (1998).
132. A. B. Argade, R. Devraj, J. A. Vroman, R. D. Haugwitz, M. Hollingshead, and M.
Cushman, "Design and Synthesis of Brefeldin A Sulfide Derivatives as Prodrug
Candidates with Enhanced Aqueous Solubilities," J. Med. Chem. 41, 3337-3346 (1998).
133. Z. Wang and M. Cushman, "An Optimized Synthesis of 2-Methoxyestradiol, a Naturally
Occurring Human Metabolite with Anticancer Activity," Synth. Commun. 28, 4431-4437
(1998).
134. M. Cushman, J. T. Mihalic, K. Kis, and A. Bacher "Design and Synthesis of 6-(6-D-
Ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexylphosphonic Acid, a Potent Inhibitor
of Lumazine Synthase," Bioorg. Med. Chem. Lett. 9, 39-42 (1999).
135. D. Strumberg, Y. Pommier, K. Paull, M. Jayaraman, P. Nagafuji, and M. Cushman,
"Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons," J. Med. Chem.
42, 446-457 (1999).
136. M. Cushman, S. Insaf, G. Paul, J. A. Ruell, E. De Clercq, D. Schols, C. Pannecouque, M.
Witvrouw, C. A. Schaeffer, J. A. Turpin, K. Williamson, and W. G. Rice, "Extension of
the Polyanionic Cosalane Pharmacophore as a Strategy for Increasing Anti-HIV
Potency," J. Med. Chem. 42, 1767-1777 (1999).
137. K. Mohanakrishnan and M. Cushman, "Pd(0)-Mediated Cross Coupling of 2-
Iodoestradiol with Organozinc Bromides: A General Route to the Synthesis of 2-Alkynyl,
2-Alkenyl and 2-Alkylestradiols," Synlett. 1097-1099 (1999).
138. M. Cushman, J. T. Mihalic, K. Kis, and A. Bacher, "Design, Synthesis, and Biological
Evaluation of Homologous Phosphonic Acids as Inhibitors of Lumazine Synthase," J.
Org. Chem. 64, 3838-3845 (1999).
139. M. Cushman, F. Mavandadi, D. Yang, K. Kugelbrey, K. Kis, and A. Bacher, "Synthesis
and Biochemical Evaluation of Bis(6,7-dimethyl-8-D-ribityllumazines) as Potential
Bisubstrate Analogue Inhibitors of Riboflavin Synthase," J. Org. Chem. 64, 4635-4642
(1999).