Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

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Mark Cushman 303. J.-H. Liang, W. Lv, X.-L. Li, K. An; M. Cushman, H. Wang, and Y.-C. Xu, " Synthesis and Antibacterial Activity of 9-Oxime Ether Non-ketolides, and Novel Binding Mode of Alkylides with Bacterial rRNA," Bioorg. Med. Chem. Lett. 23, 1387–1393 (2013). Intellectual Property Disclosures (since 2007): 1. "Anti-trypanosomal activity of topoisomerase IB-targeting indenoisoquinolines", Mark S. Cushman, Andrew Morrell, Dongpei Sang, Rahul Bakshi, and Theresa Shapiro, June 12, 2007. 2. "Hydrolytically Stable Alkenyldiarylmethane Non-nucleoside Reverse Transcriptase Inhibitors," Mark S. Cushman and Matthew Cullen, March 1, 2007. 3. "14-Substituted Aromathecin Topoisomerase I Inhibitors," Mark S. Cushman, Maris Cinelli, Andrew Morrell, and Yves Pommier, April 17, 2008. 4. "Riboflavin Synthase Inhibitors as Potential Antitubercular Agents," Mark S. Cushman, Yanlei Zhang, Markus Fischer, and Adelbert Bacher, April 8, 2009. 5. "Discovery of a Novel Indenoisoquinoline Inducer of the Retinoid X Receptor Response Element (RXRE)," Mark S. Cushman, John M. Pezzuto, Eun-Jung Park, and Andrew Morrell, June 2, 2009. 6. "Casimiroin-Based Aromatase and QR2 Inhibitors," Mark S. Cushman, John M. Pezzuto, and Arup Maiti, January 21, 2009. 7. "New Antitumor Norindenoisoquinoline Topoisomerase I Inhibitors," Mark S. Cushman, Yunlong Song, and Yves Pommier, August 11, 2009. 8. "Substituted Dibenzo[c,h]naphthyridinediones, 11-Chlorodibenzo[c,h]naphthyridinones and Dibenzo[c,h]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents," Mark S. Cushman, Evgeny Kiselev, and Yves Pommier, June 10, 2010. 9. "Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Carbohydrates," Mark S. Cushman, Katherine Peterson, Maris Cinelli, Andrew Morrell, and Yves Pommier, October 22, 2010. 10. " Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated from Streptomyces sp., Strain CNS284," Mark S. Cushman and Martin Conda-Sheridan, November 1, 2010. 11. "Preparation of Phenylthiazole Derivatives as Antiviral Agents," Abdelrahman Salah Mayhoub, Mansoora Khaliq, Richard Kuhn, and Mark S. Cushman, February 4, 2011. 12. "Preparation of Azole Derivatives as Cancer Chemopreventive Agents," Abdelrahman Salah Mayhoub, John M. Pezzuto, and Mark S. Cushman, April 1, 2011. 13. "Synthesis and Use of Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors", Mark S. Cushman and Nguyen Trung, March 8, 2012. 14. "Dibenzo[c,h][1,5]naphthyridinediones as Topoisomerase I Inhibitors: Design, Synthesis, and Biological Evaluation," Mark S. Cushman and Evgeny Kiselev, March 21, 2012. 15. "A Novel Synthesis of the Anticancer Drugs Indotecan (LMP400) and Indotecan (LMP776)," Mark S. Cushman, June 6, 2012. 16. "Antimicrobial activity of novel substituted thiazoles against methicillin-resistant Staphylococcus aureus (MRSA)", Mark S. Cushman, Abdelrahman S. Mayhoub, and Seleem N. Mohamed, September 25, 2012. 17. "Indenoisoquinoline Rexinoids with Chemopreventive Potential," Mark S. Cushman, Martin Conda-Sheridan, and John M. Pezzuto, January 7, 2013. 22
Mark Cushman 18. "Synthesis and Antibacterial Activity of 3-(3-Aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazine Inorganic Pyrophosphatase Inhibitors," Mark S. Cushman, Wei Lv, and Andrew D. Mesecar, March 12, 2013. 19. "Synthesis of Mixed (E,Z)-, (E)-, and (Z)-Norendoxifen with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities," Mark S. Cushman, David A. Flockhart, and Wei Lv," March 12, 2013. Provisional Patent Applications: 1. Mark S. Cushman, Agustin Casimiro-Garcia, and William G. Rice, United States Provisional Patent Application, "Alkenyldiarylmethane (ADAM) Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors (NNRTIs)," January 16, 1998, Purdue Reference P- 97066.00, U.S. patent application serial number 60/071,700, European Serial Number 99902293.2-2103, Purdue Reference P-97066.00.JP (Japan), U.S. Utility Application No. 09/581,927. 2. Mark S. Cushman, Ankush Argade, Rudiger Haugwitz, and Rajesh Devraj, United States Provisional Patent Application, "Brefeldin A Derivatives," December 18, 1997, Purdue Reference P-97056.00, U.S. Provisional Patent Application Number 60/068,030. 3. Mark S. Cushman, Y. Pommier, M. Jayaraman, and P. Nagafuji, "Novel Indenoisoquinolines as Antineoplastic Agents," October 30, 1998, Purdue Reference P- 98043.00.US, U.S. Provisional Patent Application Number 60/104,226, International Publication Number WO00/21537, PCT International Application Number PCT/US99/23900. 4. Mark S. Cushman and Ernest Hamel, "B-Homoestra-1,3,5(10)-trienes as Modulators of Tubulin Polymerization," October 26, 1999, Purdue Reference E-230,99/0, U.S. Provisional Patent Application Number 60/161,533, Purdue Reference P-99083.P1.US, Purdue Reference P-99083.00.WO. International Publication Number WO 01/30803 A1. October 10, 2000, International Patent Application No. PCT/US00/28273. 5. Mark S. Cushman and O.M. Zack Howard, "Inhibition of Rantes/CCR1 Mediated Chemotaxis by Novel Cosalane Compounds," November 29, 1999, PUR-130-PROV (7024-1063), P-99093.P1.US, U.S. Provisional Patent Application Serial Number 60/167,864. 6. Mark S. Cushman, Thota Sambaiah, Adelbert Bacher, and Markus J. Fischer, "Design, Synthesis, and Evaluation of 9-D-Ribitylamino-1,3,7-Trihydro-2,6,8-Purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase," November 10, 2003, P-03140.P1.US, U.S. Provisional Patent Application Serial Number 60/518,765. 7. Mark S. Cushman, Andrew E. Morrell, and Yves Pommier, "Synthesis of Nitrated Indenoisoquinolines," May 20, 2004, U.S. Provisional Patent Application P- 04074.P1.US, Serial Number 60,568,987, Purdue Reference Number 64174.P1, Barnes & Thornburg Attorney Docket Number 3220-75284. 8. Mark S. Cushman and Andrew E. Morrell, "Synthesis of Indenoisoquinolines," May 9, 2005, U.S. Provisional Patent Application, Serial Number 11/125,723, Purdue Reference Number 64074.US, Barnes & Thornburg Attorney Docket Number 3220-77873. 9. Mark S. Cushman, Andrew E. Morrell, and Yves Pommier, "Process for Preparing Indenoisoquinolines," May 21, 2004, U.S. Provisional Patent Application Number P- 04074.P1.US, Serial Number 60/572,852, Purdue Reference Number 64074.P2, Attorney Docket Number 3220-75284. This application is supplemental to the one listed directly above. 10. Mark S. Cushman and Bo-Liang Deng, "Alkenyldiarylmethanes, Fused Analogs and Synthesis Thereof," October 25, 2005, U.S. Provisional Patent Application, Purdue Reference Number 64408.P1.US, Barnes & Thornburg Attorney Docket Number 3220- 78445. 23
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