Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

Mark Cushman
239. A. Morrell, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, "Nitrated
Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and
Optimization", J. Med. Chem. 50, 4419-4430 (2007).
240. A. Talukdar, B. Illarionov, A. Bacher, M. Fischer, and M. Cushman, "Synthesis and
Enzyme Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine
Substrate of Lumazine Synthase and Product of Riboflavin Synthase," J. Org. Chem. 72,
7167-7175 (2007).
241. Y. Zhang, G. Jin, B. Illarionov, A. Bacher, M. Fischer, and M. Cushman, "A New Series
of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-
d]pyrimidinedione as Inhibitors of Lumazine Synthase: Design, Synthesis, and Biological
Evaluation," J. Org. Chem. 72, 7176-7184 (2007).
242. M. D. Cullen, B.-L. Deng, T. L. Hartman, K. M. Watson, R. W. Buckheit, Jr., C.
Pannecouque, E. De Clercq, and M. Cushman, "Synthesis and Biological Evaluation of
Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors that
Possess Increased Hydrolytic Stability." J. Med. Chem. 50, 4854-4867 (2007).
243. A. B. Edsall, G. E. Agoston, A. M. Treston, S. M. Plum, R. H. McClanahan, T.-S. Lu, W.
Song, and M. Cushman, "Synthesis and In Vivo Antitumor Evaluation of 2-
Methoxyestradiol 3-Phosphate, 17-Phosphate, and 3,17-Diphosphate," J. Med. Chem. 50,
6700-6705 (2007).
244. S. Antony, K. K. Agama, Z.-H. Miao, K. Takagi, M. H. Wright, A. I. Robles, L.
Varticovski, M. Nagarajan, A. Morrell, M., Cushman, and Y. Pommier, "Novel
Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I
Cleavage Complexes and Overcome Multidrug Resistance," Cancer Res. 67, 10397-
10405 (2007).
245. M. D. Cullen, T. Sarkar, E. Hamel, T. L. Hartman, K. M. Watson, R. W. Buckheit, Jr., C.
Pannecouque, E. De Clercq, and M. Cushman, "Inhibition of Tubulin Polymerization by
Select Alkenyldiarylmethanes," Bioorg. Med. Chem. Lett. 18, 469-473 (2008).
246. M. D. Cullen, Y.-F. Cheung, M. D. Houslay, T. L. Hartman, K. M. Watson, R. W.
Buckheit, Jr., C. Pannecouque, E. De Clercq, and M. Cushman, "Investigation of the
Alkenyldiarylmethane Non-nucleoside Reverse Transcriptase Inhibitors as Potential
cAMP Phosphodiesterase-4B2 Inhibitors," Bioorg. Med. Chem. Lett. 18, 1530-1533
(2008).
247. M. D. Cullen, D. Miles, A. Rothwell, C. Bonham, K. V. Wood and M. Cushman,
"Hydrolysis of Thioesters in an Ion Trap," Rapid Commun. Mass Spectrom. 22, 1094-
1098 (2008).
248. Y. Zhang, B. Illarionov, E. Morgunova, G. Jin, A. Bacher, M. Fischer, R. Ladenstein, and
M. Cushman, "A New Series of N-[2,4-Dioxo-6-D-ribitylamino-1,2,3,4-
tetrahydropyrimidin-5-yl]-oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase
and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography,
and Mechanistic Implications," J. Org. Chem. 73, 2715-2724 (2008).
249. Z. L. Fang, Y. Song, T. Sarkar, E. Hamel, W. E. Fogler, G. E. Agoston, P. E. Fanwick,
and M. Cushman, "Stereoselective Synthesis of 3,3-Diarylacrylonitriles as Tubulin
Polymerization Inhibitors," J. Org. Chem. 73, 4241-4244 (2008).
250. M. A. Cinelli, A. Morrell, T. S. Dexheimer, E. S. Scher, Y. Pommier, and M. Cushman,
"Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as
Topoisomerase I Inhibitors," J. Med. Chem. 51, 4609-4619 (2008).
251. Z. Li, M. Khaliq, Z. Zhou, C. B. Post, R. J. Kuhn, and M. Cushman, "Design, Synthesis,
and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins,"
J. Med. Chem. 51, 4660-4671 (2008).
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