Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

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Mark Cushman
Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each
Other, on Tubulin Assembly," Mol. Pharmacol. 70, 1555-1564 (2006).
226. M. Nagarajan, A. Morrell, A. Ioanoviciu, S. Antony, G. Kohlhagen. M. Hollingshead, Y.
Pommier, and M. Cushman, "Synthesis and Evaluation of Indenoisoquinoline
Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles," J. Med. Chem. 49,
6283-6289 (2006).
227. A. Morrell, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, "A Systematic
Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I Inhibitor," J.
Med. Chem. 49, 7740-7753 (2006).
228. E. Morgunova, B. Illarionov, T. Sambaiah, I. Haase, A. Bacher, M. Cushman, M.
Fischer, M., R. Ladenstein, "Structural and Thermodynamic Insights into the Binding
Mode of Five Novel Inhibitors of Lumazine Synthase from Mycobacterium tuberculosis,"
FEBS J. 273, 4790-4804 (2006).
229. A. Maiti, M. Cuendet, T. Kondratyuk, V. L. Croy, J. M. Pezzuto, and M. Cushman,
"Synthesis and Cancer Chemopreventive Activity of Zapotin, a Natural Product from
Casimiroa edulis," J. Med. Chem. 50, 350-355 (2007).
230. C. Y. Lee, B. Illarionov, Y.-E. Woo, K. Kemter, R.-R. Kim, S. Eberhardt, M. Cushman,
W. Eisenreich, M. Fischer, and A. Bacher, "Ligand Binding Properties of the N-Terminal
Domain of Riboflavin Synthase from Escherichia coli," J. Biochem. Mol. Biol. 40, 239-
246 (2007).
231. A. Morrell, M. S. Placzek, J. D. Steffen, S. Antony, K. Agama, Y. Pommier, and M.
Cushman, "Investigation of the Lactam Side Chain Length Necessary for Optimal
Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell
Cultures," J. Med. Chem. 50, 2040-2048 (2007).
232. H. Y. Kim, R. J. Kuhn, C. Patkar, R. Warrier, and M. Cushman, "Synthesis of Dioxane-
Based Antiviral Agents and Evaluation of Their Biological Activities as Inhibitors of
Sindbis Virus Replication," Bioorg. Med. Chem. 15, 2667-2679 (2007).
233. Y. Zhang, B. Illarionov, A. Bacher, M. Fischer, G. I. Georg, Q.-Z. Ye, D. Vander Velde,
P. E. Fanwick, Y. Song, and M. Cushman, "A Novel Lumazine Synthase Inhibitor
Derived from Oxidation of 1,3,6,8-Tetrahydroxy-2,7-naphthyridine to a
Tetraazaperylenehexaone Derivative," J. Org. Chem. 72, 2769-2776 (2007).
234. J. Kaiser, B. Illarionov, F. Rohdich, W. Eisenreich, S. Saller, J. Van den Brulle, M.
Cushman, A. Bacher, and M. Fischer, "A High Throughput Screening Platform for
Inhibitors of the Riboflavin Biosynthesis Pathway," Anal. Biochem. 365, 52-61 (2007).
235. A. Maiti, M. Cuendet, V. L. Croy, D. C. Endringer, J. M. Pezzuto, and M. Cushman,
"Synthesis and Biological Evaluation of (±)-Abyssinone II and its Analogues as
Aromatase Inhibitors for Chemoprevention of Breast Cancer," J. Med. Chem. 50, 2799-
2806 (2007).
236. T. Sakamoto, M. D. Cullen, T. L. Hartman, K. M. Watson, R. W. Buckheit, C.
Pannecouque, E. De Clercq, and M. Cushman, "Synthesis and Anti-HIV Activity of New
Metabolically Stable Alkenyldiarylmethane Non-Nucleoside Reverse Transcriptase
Inhibitors Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadiazole Systems," J.
Med. Chem. 50, 3314-3321 (2007).
237. E. Morgunova, S. Saller, I. Haase, M. Cushman, A. Bacher, M. Fischer and R.
Ladenstein, "Lumazine Synthase from Candida albicans as an Anti-Fungal Target
Enzyme: Structural and Biochemical Basis for Drug Design," J. Biol. Chem. 282, 17231-
17241 (2007).
238. A. Morrell, M. Placzek, S. Parmley, S. Antony, T. Dexheimer, Y. Pommier and M.
Cushman, "Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I
Inhibitors," J. Med. Chem. 50, 4388-4404 (2007).