Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

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Mark Cushman
212. M. Cushman, G. Jin, B. Illarionov, M. Fischer, R. Ladenstein, and A. Bacher, "Design,
Synthesis, and Biochemical Evaluation of 1,5,6,7,-Tetrahydro-6,7-dioxo-9-D-
Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine
Synthase and Riboflavin Synthase," J. Org. Chem. 70, 8162-8170 (2005).
213. A. Ramsperger, M. Augustin, A.-K. Schott, S. Gerhardt, T. Krojer, W. Eisenreich, B.
Illarionov, M. Cushman, A. Bacher, R. Huber, and M. Fischer, "Crystal Structure of an
Archaeal Pentameric Riboflavin Synthase Complex with a Substrate Analog Inhibitor:
Stereochemical Implications," J. Biol. Chem. 281, 1224-1232 (2006).
214. C. Marchand, S. Antony, K. W. Kohn, M. Cushman, A. Ioanoviciu, B. L. Staker, A. B.
Burgin, L. Stewart, and Y. Pommier, "A Novel Norindeniosoquinoline Structure Reveals
a Common Interfacial Inhibitor Paradigm for Ternary Trapping of the Topoisomerase I-
DNA Covalent Complex," Mol. Cancer Ther. 5, 287-295 (2006).
215. A. Morrell, S. Antony, G. Kohlhagen, Y. Pommier. and M. Cushman, "Synthesis of
Benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile Intermediates for the Design and
Synthesis of Topoisomerase I Inhibitors," Bioorg. Med. Chem. Lett. 16, 1846-1849
(2006).
216. X. Xiao, S. Antony, Y. Pommier, and M. Cushman, "Total Synthesis and Biological
Evaluation of 22-Hydroxyacuminatine," J. Med. Chem. 49, 1408-1412 (2006).
217. H. Y. Kim, A. Talukdar, and M. Cushman, "Regioselective Synthesis of N-β-
Hydroxyethylaziridines by the Ring Opening Reaction of Epoxides with Aziridine
Generated in situ," Org. Lett. 8, 1085-1087 (2006).
218. B.-L. Deng, M. D. Cullen, Z. Zhao, T. L. Hartman, R. W. Buckheit, Jr., C. Pannecouque,
E. De Clercq, P. E. Fanwick, and M. Cushman, "Synthesis and Anti-HIV Activity of New
Alkenyldiarylmethane (ADAM) Non-nucleoside Reverse Transcriptase Inhibitors
Incorporating Benzoxazolone and Benzisoxazole Rings," Bioorg. Med. Chem. 14, 2366-
2374 (2006).
219. N. O. Anadu, V. J. Davisson, and M. Cushman, "Synthesis and Anticancer Activity of
Brefeldin A Ester Derivatives," J. Med. Chem. 49, 3897-3905 (2006).
220. A. Morrell, M. Jayaraman, M. Nagarajan, B. M. Fox, M. R. Meckley, A. Ioanoviciu, Y.
Pommier, S. Antony, M. Hollingshead, and M. Cushman, "Evaluation of
Indenoisoquinoline Topoisomerase I Inhibitors Using a Hollow Fiber Assay," Bioorg.
Med. Chem. Lett. 16, 4395-4399 (2006).
221. S. Antony, K. K. Agama, Z.-H. Miao, M. Hollingshead, S. L. Holbeck, M. H. Wright, L.
Varticovski, M. Nagarajan, A. Morrell, M. Cushman, and Y. Pommier,
"Bisindenoisoquinoline
Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-
c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA
Intercalator and Topoisomerase Inhibitor with Antitumor Activity," Mol. Pharmacol. 70,
1109-1120 (2006).
222. M. Nagarajan, A. Morrell, S. Antony, G. Kohlhagen, K. Agama, Y. Pommier, P. A.
Ragazzon, N. C. Garbett, J. B. Chaires, M. Hollingshead, and M. Cushman, " Synthesis
and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors," J.
Med. Chem. 49, 5129-5140 (2006).
223. B.-L. Deng, T. L. Hartman, R. W. Buckheit, Jr., C. Pannecouque, E. De Clercq, and M.
Cushman, "Replacement of the Metabolically Labile Methyl Esters in the
Alkenyldiarylmethane (ADAM) Series of Non-nucleoside Reverse Transcriptase
Inhibitors (NNRTIs) with Isoxazolone, Isoxazole, Oxazolone, or Cyano Substituents," J.
Med. Chem. 49, 5316-5323 (2006).
224. X. Xiao, A. Morrell, P. E. Fanwick, and M. Cushman, "On the Mechanism of Conversion
of 4-Carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to Indeno[1,2-c]isoquinolines
by Thionyl Chloride," Tetrahedron 62, 9705-9712 (2006).
225. E. Hamel, B. W. Day, J. H. Miller, M. K. Jung, P. T. Northcote, A. K. Ghosh, D. P.
Curran, M. Cushman, K. C. Nicolaou, I. Paterson, and E. J. Sorensen, "Synergistic