Curriculum vitae for mark cushman - Purdue College of Pharmacy ...

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Mark Cushman
183. M. A. Silvestri, D. Miles, A. P. Rothwell, K. V. Wood, and M. Cushman, "The
"Apparent" Hydrolysis of Alkyl Esters During Electrospray Ionization," Rapid Commun.
Mass Spectrom. 17, 1703-1708 (2003).
184. X. Zhang, W. Meining, M. Cushman, I. Haase, M. Fischer, A. Bacher, and R. Ladenstein,
"A Structure-based Model of the Reaction Catalyzed by Lumazine Synthase from Aquifex
aeolicus, "J. Mol. Biol 328, 167-182 (2003).
185. B. M. Fox, X. Xiao, S. Antony, G. Kohlhagen, Y. Pommier, B. L. Staker, L. Stewart,
and M. Cushman, "Design, Synthesis, and Biological Evaluation of Cytotoxic 11-
Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline-
Camptothecin Hybrids," J. Med. Chem. 46, 3275-3282 (2003).
186. S. Antony, M. Jayaraman, G. Laco, G. Kohlhagen, K. W. Kohn, M. Cushman, and Y.
Pommier, "Differential Induction of Topoisomerase I-DNA Cleavage Complexes by the
Indenoisoquinoline MJ-III-65 (NSC 706744) and Camptothecin: Base Sequence Analysis
and Activity against Camptothecin-Resistant Topoisomerase I," Cancer Res. 63, 7428-
7435 (2003).
187. M. Nagarajan, X. Xiao, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman,
"Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I
Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen," J. Med. Chem. 46,
5712-5724 (2003).
188. M. Fischer, A.-K. Schott, K. Kempter, R. Feicht, G. Richter, B. Illarionov, W. Eisenreich,
S. Gerhardt, M. Cushman, S. Steinbacher, R. Huber, and A. Bacher, "Riboflavin
Synthase of Saccharomyces pombe. Protein Dynamics Revealed by 19 F NMR Protein
Perturbation Experiments," BMC Biochem. 4, 18 (2003).
189. M. Cushman, T. Sambaiah, G. Jin, B. Illarionov, M. Fischer, and A. Bacher, "Design,
Synthesis, and Evaluation of 9-D-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones
Bearing Alkyl Phosphate and α,σ-Difluorophosphonate Substituents as Inhibitors of
Riboflavin Synthase and Lumazine Synthase, J. Org. Chem. 69, 601-612 (2004).
190. B. D. Gehm, A. S. Levenson, H. Liu, E.-J. Lee, B. M. Amundsen, M. Cushman, V. C.
Jordan, J. L. Jameson, "Estrogenic Effects of Resveratrol in Breast Cancer Cells
Expressing Mutant and Wild-type Estrogen Receptors: Role of AF-1 and AF-2," J.
Steroid Biochem. Mol. Biol. 88, 223-234 (2004).
191. M. A. Silvestri, M. Nagarajan, E. De Clercq, C. Pannecouque, and M. Cushman, "Design,
Synthesis, Anti-HIV Activities, and Metabolic Stabilities of Alkenyldiarylmethane
(ADAM) Non-nucleoside Reverse Transcriptase Inhibitors," J. Med. Chem. 47, 3149-
3162 (2004).
192. A. Morrell, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, "Synthesis of
Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors," Bioorg. Med. Chem. Lett.
14, 3659-3663 (2004).
193. M. Koch, C. Breithaupt, S. Gerhardt, I. Haase, S. Weber, M. Cushman, R. Huber, A.
Bacher, and M. Fischer, "Structural Basis of Charge Transfer Complex Formation by
Riboflavin Bound to 6,7-Dimethyl-8-ribityllumazine Synthase," Eur. J. Biochem. 271,
3208-3214 (2004).
194. X. Xiao, S. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, "Design, Synthesis,
and Biological Evaluation of Cytotoxic 11-Aminoalkenylindenoisoquinoline and 11-
Diaminoalkenylindenoisoquinoline Topoisomerase I Inhibitors," Bioorg. Med. Chem. 12,
5147-5160 (2004).
195. X. Xiao, P. E. Fanwick, and M. Cushman, "Synthesis, Crystal Structure and Conversion
of the Polycyclic Tris-anhydrotetramer of o-Aminobenzaldehyde to Cu(TAAB) 2+ ,
Synthetic Communications 34, 3901-3907 (2004).
196. X. Xiao, S,. Antony, G. Kohlhagen, Y. Pommier, and M. Cushman, "A Novel
Autoxidative Cleavage Reaction of 9-Fluoredenes Discovered During the Synthesis of a
Potential DNA-Threading Agent," J. Org. Chem. 69, 7495-7501 (2004).
197. J. Chen, T. Sambaiah, B. Illarionov, M. Fischer, A. Bacher, and M. Cushman, "Design,
Synthesis, and Evaluation of Acyclic C-Nucleoside and N-Methylated Derivatives of the
Ribitylaminopyrimidine Substrate of Lumazine Synthase as Potential Enzyme Inhibitors
and Mechanistic Probes," J. Org. Chem. 69, 6996-7003 (2004).