Fully Automated Sample Processing and HTP ... - PerkinElmer
Fully Automated Sample Processing and HTP ... - PerkinElmer
Fully Automated Sample Processing and HTP ... - PerkinElmer
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Value of Protease Deficient Hosts<br />
Problem: Yeast toolbox ineffective resulting in proteolytic degradation, very high<br />
heterogeneous glycosylation<br />
“Stacked” protease deletion strain with very high titer (>1 g/L in 96 well), superior<br />
product quality, no degradation or heterogeneity, soluble <strong>and</strong> active protein<br />
Protease Knockout<br />
Null 1 2 1+2 STD Spike<br />
0.5mg/mL<br />
Host Strain Choice Controls<br />
Expression Level <strong>and</strong> Quality<br />
Full length<br />
clipped<br />
Discovery ● Development ● Production<br />
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