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Fully Automated Sample Processing and HTP ... - PerkinElmer

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Expression analysis: <strong>Sample</strong> Preparation Bottleneck<br />

challenge: to accurately analyze target in complex mixture of solids, protein, DNA, etc. in timely fashion<br />

samples:<br />

whole cells<br />

<strong>HTP</strong> strain selection<br />

1000s of samples<br />

Fermentation<br />

Optimization<br />

sample<br />

h<strong>and</strong>ling<br />

<strong>and</strong> cell<br />

lysis<br />

separation<br />

of soluble<br />

<strong>and</strong><br />

insoluble<br />

fractions<br />

analysis<br />

100s of samples<br />

Goal<br />

“Old” process steps<br />

semi-automated,<br />

manual labels,<br />

labor intensive<br />

centrifugation in<br />

multiple rounds;<br />

manual h<strong>and</strong>ling<br />

Improve throughput <strong>and</strong> efficiencies through automation while<br />

maintaining high-quality analytical support<br />

Discovery ● Development ● Production

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