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Decrease in 2,3-DPG • Hb is a tetramer of 4 proteins each containing a heme unit • 2,3-diphosphoglycerate is a small molecule that binds into the Hb tetramer • 2,3-DPG promotes oxygen offloading in hypoxic areas
Decrease in 2,3-DPG • 2,3-DPG is depleted during storage • Its decline is mirrored by an increase in Hb oxygen saturation • 2,3-DPG is restored 24-72 hours after transfusion Bennett-Guerrero et al. PNAS, 2007
Page 1 and 2: Department of Pathology, University
Page 3 and 4: The RBC storage lesion • As RBCs
Page 5: How has the RBC storage lesion been
Page 9 and 10: k off , oxygen off loading rate con
Page 11 and 12: Other biochemical/membrane changes
Page 13 and 14: How has the RBC storage lesion been
Page 15 and 16: Analysis of tissue oxygenation •
Page 17 and 18: Analysis of tissue oxygenation •
Page 19 and 20: Conclusions • No clinical outcome
Page 21 and 22: Schieẞ ein Tor…
Page 23 and 24: Retrospective studies - Pro • Ret
Page 25 and 26: Remember… • # RBCs transfused i
Page 27 and 28: Koch et al. NEJM 2008 Both groups o
Page 29 and 30: Outcome measures were broad and not
Page 31 and 32: Conclusions • Mortality end point
Page 33 and 34: Another retrospective study of mort
Page 35 and 36: Koch et al. 10 km
Page 37 and 38: Patient demographics • The recipi
Page 39 and 40: Causes of mortality • Compared re
Page 41 and 42: Another retrospective study of mort
Page 43 and 44: RECESS study 2 prospective randomiz

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