CURRICULUM VITAE - University of Peradeniya

CURRICULUM VITAE
Desiree Nedra Karunaratne
PERSONAL DATA
OCCUPATION
Address: Home:
Official:
Professor
37/7A Anniewatte Road, Kandy, Sri Lanka.
Tel: + 94 81 2223906
Dept. of Chemistry, Faculty of Science,
University of Peradeniya, Sri Lanka,
Tel: + 94 81 2394450; Fax: + 94 81 2388018 ;
Email: nedrak@pdn.ac.lk
CITIZENSHIP Sri Lankan .
PROFESSIONAL COMPETENCE
EDUCATION :
Undergraduate & Graduate
Ph.D. in Chemistry - May 1985. Thesis Title: Structural elucidation and bacteriophage
degradation of bacterial polysaccharides.Thesis Advisor - Prof. G.G.S. Dutton.
University of British Columbia, Vancouver, B.C. Canada –
B.Sc.Special Degree - August 1979 (Upper Second Class Honours)
Chemistry major with Applied Mathematics as subsidiary
University of Colombo, Colombo. Sri Lanka.
POSTDOCTORAL
Visiting Scientist
2010-(Aug - Nov) and 2011 (July – Oct)
Department of Chemical Engineering, University of Waterloo,
Waterloo, Ontario, Canada
Research Fellow 2002-2003
Department of Pharmaceutical Chemistry
University of Kansas, Lawrence,KS, USA
Research Associate 1990-1996
Department of Microbiology and Immunology,
Vancouver, British Columbia, Canada
CIDA/NSERC Research Associate 1988 (Oct-Dec), 1989 Oct- 1990 May.
Department of Microbiology,
University of British Columbia, Vancouver,B.C. Canada
Visiting Scholar, 1987
Department of Chemistry, Mahidol University,
Bangkok, Thailand
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RESEARCH EXPERIENCE
2010 -2011 Peptides as a novel carrier for delivery of drugs and siRNA.
2004 to date Nanotechnology applications related to polymer nanoparticles and
liposomes for delivery of active ingredients in pharmaceutics,
cosmetics and food.
Carbohydrate liquid crystals with surfactant properties for use as
emulsifiers and their function in microemulsion formation.
Studies on antioxidant and anti microbial properties of some
natural products.
2002-2003 Studies on drug transport in Human placental cells.
1989-1996. Structural aspects of Pseudomonas aeruginosa
Caulobacter cresentus S-LPS.
Permeability studies through bacterial cell membranes.
Synthesis of -cyclodextrin linked lactams.
Peptide design – modeling of novel antimicrobial peptides.
Cloning and expression of an antibacterial cationic peptide using PCR
methodology.
1986-1990 Analysis of the capsular Polysaccharide of E.coli K45.
1987 Studies on the influence of outer membrane antigens of erythrocytes in
infection by the malaria parasite Plasmodium falciparum.
1985-1986 Isolation and purification of carcinoembryonic antigen (CEA) from
colorectal carcinomas.
1980-1985 Structural analysis and bacteriophage degradation of Klebsiella and E. coli
capsular polysaccharides.
AWARDS FOR RESEARCH OR INNOVATIVE PROJECTS
(PRINCIPAL INVESTIGATOR OR CO-PRINCIPAL INVESTIGATOR)
1. Glycolipids for liposome and microemulsion formation for applications in the pharmaceutical and cosmetic
industry. National Research Council (RG 11-70). 2011 - 2013.
2. Improving the bioavailability of Natural bioactive components for drug and cosmetic based applications.
HETC-QIG W3 Grant, University of Peradeniya. 2012-2014
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3. Glycolipid formulations for stabilization of bioactive compounds and micro emulsion formation. National
Science Foundation RG /2011/BS/02) 2011 -2014
4. Presidential award for research: 2002 (received in October 2008)
5. Development of basic techniques for Nanoencapsulation of bioactive bioactive compounds. National Science
Foundation RG /2010/NANO/04) 2010 -2013
6. Enhancing the efficacy of natural products through nano-encapsulation. University of Peradeniya Research
Grant (RG/2008/49/S) 2008 - 2009
7. Synthesis of glycolipids with liquid crystal properties. University of Peradeniya Research Grant
(RG/2008/48/S). 2008 - 2009
8. Enhancing the efficacy of natural products through nano-encapsulation. International Foundation for Science (
Grant # F/4455-1 ). 2008-2009
9. Synthesis and Glycolipids for use as liquid crystals and surfactants. National Science Foundation (RG
/2007/FR/05). 2008 - 2010
10. Investigation and development of the uses of glycolipids isolated from natural sources and prepared by
synthesis as liquid crystals and surfactants. National Research Council (RG 06-25). 2008 - 2010
11. Synthesis and isolation of Glycolipids for use as surfactants.University of Peradeniya Research Grant.
(RG/2006/50/S and RG/2007/C-1/40/S) 2006 - 2007
12. Structure determination of the 'O' antigen from E. coli K45. Third World Academy of Sciences, Trieste, Italy.
Grant no. TWAS RG 50 SRI 3. 1988 - 1990
13. Capsular Polysaccharide from E. coli O4:K3:H5 .International Foundation of Science, Uppsala, Sweden. 1988 -
1990
14. Capsular Polysaccharide from E. coli O4:K3:H5 .Natural Resources, Energy & Science Authority of Sri Lanka.
(RG/87/C/11 and RG/89/C/2) 1987 - 1990
15. Bacterial Polysaccharides from E.coli sp.University of Peradeniya Research Grant (RG/43/87/M) 1987
GRADUATE RESEARCH STUDENTS, STUDENT COLLABORATORS &
TECHNICAL ASSISTANTS SUPERVISED
2012 – to date D.M.D. Samantha Dissanayake (M.Phil. on going)
Glycolipids for liposome and microemulsion formation for applications in the pharmaceutical and
cosmetic industry
2012 – to date K.A.N.P. Katuvawila (M.Phil. on going)
Natural bioactive components for drug and cosmetic based applications.
2011 – to date E.P.N.Premaratne. (M.Phil. on going)
Formation of emulsions for carrying active components in cosmetic applications
2011 – to date K.M.G. Pamunuwa (Ph.D. on going)
Liposomes for encapsulating bioactive materials
2011 – to date M.S.K . Menikarachchi. (M.Phil. ongoing)
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Development of a method for encapsulating drugs using cationic polymers
2010 – to date G. Ekanayake. M.Sc. Nanoscience and Nanotechnology- (writing up)
2009 – 2012 K.M.D Gunathilake M.Phil (2012)
Microorganisms and microbial biofilms as agents for cellulosic biodegradation of invasive weeds
in Sri Lanka.
2009 –2011 L.S Hewawarawita. M.Sc. Nanoscience and Nanotechnology – (2011)
Formulation of liposomes with glycolipids for use as drug carriers.
2008 to 2010 A.R.N.M. Abeyeratne. M.Phil. (2012)
Synthesis of Glycolipids with liquid crystal and surfactant properties.
2008-2009 P.M.G. Muditha Gnanaratne. M.Sc. Industrial Chemistry (2011)
Feasibiity study of Biodiesel production from locally available non edible oils.
2008- 2009 R.M.C.K. Ratnayake. M.Sc. Science Education- Chemistry (2010)
Evolution of Organic Chemistry content in Sri Lankan schools with special reference to
advanced level syllabus.
2008 -2009 N.M.I.U Kumara. M.Sc. Industrial Chemistry. (2009)
Some formulation studies of toothpaste using Euginol rich flavour and calcium
carbonate.
2007-2012 L.L.W.C Yalegama Ph.D (2012)
Characterization and nutritional effects of cell wall polysaccharides from Coconut Kernel.
2007– 2008 R.P.H.Ranasinghe. M.Sc. Science Education- Chemistry (2011)
2006 - 2008 N.B. Jayaratne. (M.Phil. incomplete)
Effect of caffeine and epigallocatechin gallate (EGCG) on Monacrosporium ambrosium symbiote
of the shot hole borer beetle of tea.
2006- 2007 K.D.Bandula Kumara. M.Sc. Science Education- Chemistry (2009)
Introducing “Household Chemistry” for Advanced Level Chemistry syllabus.
1988 – 1989 U.A.K. Wickramasinghe. (volunteer post graduate student)
Preliminary investigation into the structure of the capsular K antigen from E. coli K 45.
1986 B.Rabel . M.Sc Biochemistry. (1987)
Isolation and purification of carcinoembryonic antigen (CEA) from colorectal carcinomas.
SCHOLASTIC AND ACADEMIC HONOURS
2006-2007 Member Consultative Committee on Equipment Requirement for the Sri
Lanka Institute of Nanotechnology and Convenor, for the area of
Nanomedicine, National Science Foundation of Sri Lanka
2002-2003 Research Fellow, Department of Pharmaceutical Chemistry University of
Kansas, USA
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1988 and 1999 Research Fellow- Canadian International Development
Agency/National Science and Engineering Research Council of Canada.
Department of Microbiology and Immunology, University of British
Columbia, Vancouver, B.C., Canada.
COURSES TAUGHT
Undergraduate courses:
Undergraduate courses in organic chemistry and basic biochemistry.
Laboratory Courses:
Laboratory courses in organic chemistry and biochemistry.
Postgraduate courses:
Organic chemistry related courses pertaining to carbohydrates, applications in paints and
nanobiochemistry.
ACADEMIC APPOINTMENTS
2010 to date Professor of Chemistry
Dept. of Chemistry, University of Peradeniya, Sri Lanka.
2007 – 2010 Associate Professor of Chemistry
Dept. of Chemistry, University of Peradeniya, Sri Lanka.
2004 – 2007 Senior Lecturer in Chemistry,Grade 1
Dept. of Chemistry, University of Peradeniya, Sri Lanka.
1996 - 2004 Senior Lecturer in Chemistry, Grade 1
The Open University of Sri Lanka, Kandy Regional Centre, Polgolla, Sri
Lanka.
1986- 1990 Lecturer in Biochemistry.
Faculty of Medicine, University of Peradeniya, Sri Lanka
1985 - 1986 Assistant Lecturer in Biochemistry,
Faculty of Medicine, University of Colombo, Sri Lanka.
1980 - 1985 Teaching Assistant.
Dept. of Chemistry, Univ. of British Columbia, Vancouver, B.C. Canada.
1979 - 1980 Temporary Demonstrator,
Dept. of Chemistry, University of Colombo, Sri Lanka.
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PROFESSIONAL ACTIVITIES
Invited Lectures/Workshops/Responsibilities
Feb 2013
Jan 2012
June 2010
Dec. 2009
April 2009
June 2008
Oct. 2007
Nov. 2006
Oct. 2005
Review Board Member, Journal of Food Chemistry and Nutrition
(http://escijournals.net/JFCN). Open access International journal.
Editor, “The complex world of Polysaccharides”. InTech open access
publishers. Published October 31 st 2012. . ISBN 978-953-51-0819-1
http://www.intechopen.com/books/the-complex-world-of-polysaccharides
Secretary, Organizing Committee. International Symposium on
Natural Products. Organized by the Dept. of Chemistry, Univ. of Peradeniya.
Invited speaker, Awareness seminar on Nanotechnology: Opportunities
and Challenges. Jointly Organized by the NSF & SLAAS.
Invited speaker, Seminar on Nanotechnology application in Food
& Agriculture. Jointly Organized by the NSF & the SMED of FCCISL
Invited Speaker, Training Workshop on Exploring Opportunities in
Nanoscience and Nanotechnology. Organized by the Post Graduate Institute of
Science, Institute of Engineers Sri Lanka and National Science Foundation, Sri Lanka. .
Invited speaker at the Techno 2007 Engineering and Technology
conference. Title of talk: Biological and Medical Applications of
Nanotechnology.
Resource person at 2 nd National Workshop on Sri Lankan Lichens.
Organized by the Dept.s of Botany and Chemistry, University of Peradeniya, and the
Dept. of National Botanic Gardens, Peradeniya..
Invited Speaker at Workshop on Nanoscience and Technology.
Organized by the National Science Foundation, Sri Lanka.
2004 – 2008 Chief Examiner. General Certificate of Education (Advanced Level
Chemistry), Dept of Examinations, Sri Lanka.
Aug. 2000
Jun /Aug 1999
Resource person at the Regional Workshop on "Curriculum Development
for Diploma Programme in Laboratory Technology". Sponsored by the
Commonwealth of Learning, Canada.
Invited Speaker at Workshop on "Nutrition and Food Security". Organized
by FAO/UNICEF/Science Education Unit of the University of Peradeniya. Sri Lanka.
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PARTICIPATION AT WORKSHOPS FOR PROFESSIONAL DEVELOPMENT
Sept. 2012
Jan. 2012
July 2010
Mar 2009
Nov. 2008
Oct. 2008
Sept. 2008
May 2008
July 2007
Aug. 2006
Participant at Workshop on Ethical and Moral challenges of Nanotechnology.
Conducted by the National Science Foundation and IDRC (International
Developmnet Research Centre) at the Colombo city Hotel.
Participant at work shop for effective technical grant proposal writing. Conducted
by the National Science Foundation.
Participant in the Sixth Sri Lanka Conference on Science and Technology
(BICOST VI). National Science and Technology Policy for Sri Lanka. Organized
by the National Science and Technology Commission (NASTEC), Kandy Sri Lanka
Participant in Nanotechnology Policy for Sri Lanka, stakeholder meeting. NSF,
Sri Lanka
Participant in Seminar and Panel discussion on GMO, GM crops, Feed, Food and
processed Products, at the Plant Genetic Resources centre, Gannoruwa, Sri Lanka.
Participant in Workshop on Curriculum Revision for the B. Pharmacy Degree.
Faculty of Allied Health Sciences, University of Peradeniya.
Participant in Workshop on External Degrees. Organized by the University Grants
Commission and The Distance Education Modernization Project. HARTI Colombo, Sri
Lanka.
Participant in the Fifth Sri Lanka Conference on Science and Technology
(BICOST V). National Science and Technology Policy for Sri Lanka. Organized by
the National Science and Technology Commission (NASTEC), Kandy Sri Lanka
Participant in Study Tour to University Sains Malaysia to study the delivery and
conduct of programmes through distance mode.
Participant in Workshop on “Neem Research and Applications: Current Trends
and Future Prospects”.Organized by the National Science Foundation, Sri Lanka.
June 2006 Participant in Workshop on Principles and Practice of Counselling
& June 2007 Organized by the IRQUE project at the University of Peradeniya.
Oct. 2005
Sept. 2005
Feb 2004
Participant in Seminar on application of HPLC. Organized by Hemsons
International (Pte) Ltd.
Participant in Workshop on Curriculum Revision as part of IRQUE project.
Organized by the Faculty of Applied Sciences, Rajarata University, Polgolla.
Participant in Training Seminar on "GMP for industries to improve productivity".
Organized by the Institute of Chemistry, Ceylon.
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July 2002
Participant in Course leading to Certificate in Radiation Safety.
Conducted at the University of Kansas, Lawrence, KS, USA.
PARTICIPATION AT PROFESSIONAL MEETINGS
2012 Participant at the First National Nanotechnology conference at the Mt. Lavinia Hotel, Sri
Lanka
2012 Participant. International conference on Chemical Sciences. Institute of Chemistry,
Colombo, Sri Lanka
2011 Participant. Global Forum for Sri Lankan Scientists. Organized by the National
Science Foundation, Sri Lanka and UNESCO at Hotel Galadari, Colombo.
2010 Participant. Fourth Symposium on Health Technology, University of Waterloo, Canada.
2010 International Symposium on Natural Products. Organized by the Dept. of Chemistry,
University of Peradeniya.
2008 International Conference on Advances in Continuum Mechanics, Material Science,
Nanoscience and Nanotechnology.
Faculty of Engineering, University of Peradeniya, Sri Lanka.
2007 National Conference on Advanced Materials for Emerging Technologies, Peradeniya, Sri
Lanka.
2007 CHEMTECH 2007, International Conference on Chemistry, Technology and
Innovation for Greater Safety and Economic Growth. Colombo, Sri Lanka.
2003 2nd Annual Kansas City Life Sciences Research Day, Kansas City, MO, USA.
2002 35 th Higuchi Conference in Pharmaceutical Chemistry, Lawrence, Kansas, USA.
2003 36 th Higuchi Conference in Pharmaceutical Chemistry, Lawrence, Kansas, USA.
1995 14 th American Peptide Symposium, Columbus, OH, USA
1994 Annual Meeting of the Canadian Society of Microbiology, Kananaskis, Canada
1993 Pharmaceutical Biotechnology Conference, Association of Faculties of Pharmacy of
Canada, Vancouver, Canada.
1993 4 th International Symposium on Psuedomonas: Biotechnology and Molecular
Biology. Vancouver, B.C. Canada.
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1992 Annual Meeting of the Australian Society of Microbiology, Sydney, Australia
1982 XIth International Carbohydrate Symposium, Vancouver, Canada.
1981 28th IUPAC Congress, Vancouver, Canada.
SCHOLARLY CONTRIBUTIONS IN PEER-REVIEWED JOURNALS
1 Chemical and functional properties of fibre concentrates obtained from by-products of coconut
kernel L.L.W.C. Yalegama, D. Nedra Karunaratne, Ramiah Sivakanesan and Chithrangani
Jayasekara. Submitted to Journal of Food Science and Technology 2012
2 Surfactant behavior of novel carbohydrate liquid crystals. A R N M Abeyrathne, A D L C Perera
and D N Karunaratne Submitted to Journal of the National Science Foundation 2012
3 Evaluation of Cellulose Degrading Efficiencies of Fungal and Bacterial monocultures and
Fungal-Bacterial Biofilms. K.M.D. Gunathilake, R.R. Ratnayake, S.A. Kulasooriya, D.N.
Karunaratne- Submitted to Journal of the National Science Foundation 2012
4 Physicochemical characterization, stability studies and delivery efficiency of C6M1 peptide.
Mousa Jafari, Wen Xu, Ran Pan, Chad M. Sweeting, D. Nedra Karunaratne, and P. Chen. In
preparation.
5 Modification of a designed amphipathic cell penetrating peptide and its effect on solubility,
secondary structure and efficiency. Mousa Jafari, D. Nedra Karunaratne,, Chad M. Sweeting, and
P. Chen. Submitted to Biochemistry.
6 A R N M Abeyrathne, A D L C Perera and D N Karunaratne. (2012). Liquid crystal behaviour
of three novel glycosides. Journal of the National Science Foundation, 40 115 -121
7 M. Jafari, M. Soltani, S. Naahidi, D.N. Karunaratne and P. Chen. (2012). Nonviral
approach for targeted nucleic acid delivery, Current Medicinal Chemistry 19 197 – 208
8 S. Puvanendran, T. Manoranjan, A. Wickramasinghe, D.N. Karunaratne, D.S.A.
Wijesundara, V. Kumar, G. Carr, R.J. Andersen, V. Karunaratne. (2010) Alkaloids
from Xylopia parvifolia and Xylopia nigricans (Annonaceae)
Journal of the National Science Foundation, 38 75 – 76.
9 N.B. Jayaratne, D.N. Karunaratne and N.S. Kumar. (2009) Effect of caffeine and a tea
flavanoid on Monacrosoprium ambrosium, ecto-symbiote of shot-hole borer beetle of tea.
Journal of the National Science Foundation, 37 273 – 275.
10 S. Puvanendran, A. Wickramasinghe, D.N. Karunaratne, G.Carr, D.S.A. Wijesundara,
R. Andersen, and V. Karunaratne. (2008) Antioxidant constituents from Xylopia
championii. Pharmaceutical Biology . 46 352 – 355.
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11 D.N. Karunaratne. (2007) Nanotechnology in Medicine. Journal of the National
Science Foundation. 35 149 – 152.
12 D.N. Karunaratne and K.L. Audus. (2007) Use of fluorescent probes to monitor the
efflux transporters P-glycoprotein and MRP1 in BeWo cells. Journal of the National
Science Foundation, 35 19 – 27.
13 T. Nanovskaya, I Nekhayeva, N. Karunaratne, K. Audus, G.D.V. Hankins, M.S.
Ahmed. (2005) Role of P-glycoprotein in transplacental transfer of methadone.
Biochemical Pharmacology, 69 1869 – 1878.
14 V. Karunaratne, K. Bombuwela, S Kathirgamanathan, D.N. Karunaratne, K.B.
Ranawana, D.S.A.Wijesundera, A. Weerasooriya, V. Kumar and E.D. De Silva. (2002)
An association between the butterfly Talicada nyseus and the lichen Leproma
sipmanianum as evidenced from chemical studies.
Current Science, 83 741 - 745.
15 C. C. Freidrich, M.G. Scott, N. Karunaratne, H. Yan and R.E.W. Hancock (1999). Salt
resistant -helical cationic antimicrobial peptides. Antimicrobial Agents and
Chemotherapy. 43 1542 - 1548.
16 M. Houston, L. Kondejewski, D.N. Karunaratne, M. Gough, S. Fidai, R. Hodges, and
R.E.W. Hancock. (1998) Influence of preformed helix and helix induction on the
activity of cationic antimicrobial peptides.
Journal of Peptide Research, 52 81 - 88.
17 T.J. Falla, D.N. Karunaratne, and R.E.W. Hancock. (1996) Mode of action of the
antimicrobial peptide Indolicidin.
Journal of Biological Chemistry, 271 19298 – 19303.
18 S.G. Walker, D.N. Karunaratne, N. Ravenscroft, and J. Smit. (1994) Characterization of
mutants of Caulobacter cresentus defective in surface attachment of the paracrystalline
surface layer.
Journal of Bacteriology, 176 6312 - 6323.
19 D.N. Karunaratne, S. Farmer, and R.E.W. Hancock. (1993) Synthesis of bulky
lactams for inhibition of cell surface lactamase activity.
Bioconjugate Chemistry, 4 434 – 439.
20 D.N. Karunaratne, J.C. Richards, and R.E.W. Hancock. (1992) Characterization of
Lipid A from Pseudomonas aeruginosa O Antigenic B band Lipopolysaccharide by 1D
and 2D NMR and mass spectral analysis.
Archives of Biochemistry and Biophysics, 299 368 – 376.
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21 G.G.S. Dutton, D.N. Karunaratne, and A.V.S. Lim. (1988) Escherichia coli serotype
K44: an acidic capsular polysaccharide containing two 2-acetamido-2-deoxy hexoses.
Carbohydrate Research, 183 111 – 122.
22 J.L. Di Fabio, D.N. Karunaratne and G.G.S. Dutton. (1986) Novel oligosaccharides
obtained by bacteriophage degradation of the polysaccharide from Klebsiella serotype
K26.
Carbohydrate Research, 144 251 – 261.
23 G.G.S. Dutton, and D.N. Karunaratne. (1985) Bacteriophage degradation of
Klebsiella K44 polysaccharide: an NMR study and chemical proof of the
position of the acetate group.
Carbohydrate Research, 138 277 – 291.
24 G.G.S. Dutton, and D.N. Karunaratne. (1984) Structural investigation of the Capsular
polysaccharide of Klebsiella serotype K80.
Carbohydrate Research, 134 103 – 114.
25 G.G.S. Dutton, and D.N. Karunaratne. (1983) Structural investigation of the Capsular
polysaccharide of Klebsiella serotype K67.
Carbohydrate Research, 119 157 – 169.
26 N. Segond, M.-A. Chalvignac, R. Gavard, R. Tinelli, J.L. Di Fabio, D.N. Karunaratne
and G.G.S. Dutton. (1983) Etude d’un polyoside de Bacillus megaterium.
Carbohydrate Research, 119 117 – 128.
27 H.D. Gunawardhana, and D.N. Wikramanayake. (1982) Extraction of Titanium using a
castor oil based ligand. Indian Journal of Chemistry, 21A 88 - 90.
PATENTS
28 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent
application 08/460,464, Filed, 02 Jul 1995.US Patent No 5,877,274, issued March 2, 1999.
29 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent CIP (of
08/460,464) serial no 08/658,857, filed May 31, 1996, US Patent No 6,040,435 issued
March 21, 2000.
30 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent CIP (of
08/658,857)serial no 08/763,226 filed Dec 10, 1996, US Patent No 6,057,291 issued May
2, 2000.
31 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent CIP (of
08/658,857) serial no 09/307,200 filed May 7, 1999. US Patent No 6,297,215 issued Oct 2,
2001.
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32 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent CIP (of
08/658,857) serial no 09/593,321 filed June 13, 2000. US Patent No 6,465,429 issued Oct
15, 2002.
33 Antimicrobial cationic peptides R.E.W. Hancock and N. Karunaratne. US patent CIP (of
08/658,857) serial no 09/593,321 filed June 13, 2000. US Patent No 6,906,035 issued Jun
14, 2005.
34 Method and composition of thermally stabilizing Vitamin C within nanolayers of
Montmorillonite clay. C. G. Gunasekara, V.N. Seneviratne, D.N. Karunaratne and V.
Karunaratne. US patent filing date 10 th January, 2010; Application Serial Number
12696048.
35 Method and compositions for topical vitamic C compositions: US provisional patent
application filing date 3 rd July, 2010; Application Serial Number: 61/361,382.
36 Peptide sequence design and the use thereof for peptide mediated siRNA delivery. P.Chen,
M. Jafari, W. Xu, B. Chen, R. Pan, N. Karunaratne. US Patent Application no: 61/563,591
filed 24th November 2011
BOOKS AND MONOGRAPHS
37 D.N. Karunaratne, R.G.U. Jayalal and V. Karunaratne. (2012). “Lichen Polysaccharides”
in The Complex World of Polysaccharides, Desiree Nedra Karunaratne (Ed), In Tech
open access publishers. Chapter 8 pp 215-226. ISBN 978-953-51-0819-1Available from:
http://www.intechopen.com/books/the-complex-world-of-polysaccharides/lichenpolysaccharides.
38 M. Jafari, M. Soltani, B. Zargar, D.N. Karunaratne, B. Ingalls and P. Chen. (2012).
“Intelligent drug delivery systems for cancer therapy”, in Biomedical Materials and
Diagnostic Devices, (Eds) Ashutosh Tiwari, Murugan Ramalingam, Hisatoshi Kobayashi
and Anthony P.F. Turner. Wiley-Scrivener Publishing LLC, Salem,USA. Chapter 15 pp
477-513. ISBN 978-1-1180-3014-1
39 Karunaratne, D.N., (2006). Oils and Fats in Industry, Peradeniya University Science
Education Unit Publication.
40 Karunaratne, D.N., Silverstein, P.S., Vasandani, V., Young, A.M., Rytting, E., Yops, B.,
and Audus, K.L. (2005) Cell culture models for drug transport studies, in Drug Delivery:
Principles and Applications (Wang, B., Siahaan, T.J., and Soltero, R.A, Eds.), pp. 103-125,
John Wiley & Sons, Inc., New York.
41 P.Silverstein, D.N. Karunaratne and K.L Audus. (2003). "Utilization of uptake studies for
evaluating activity of efflux transporters" Curr. Protocols Pharmacol. Supplement 23,
7.7.1-7.7.14. John Wiley & Sons, Inc., New York.
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42 D.N. Karunaratne. Natural Product Chemistry- CHU 3131. ( volume II, Proteins and
Nucleic acids) 2001 An Open University publication for undergraduate teaching at the third
year level.
43 D.N Karunaratne. Biochemistry- CHU 3139. ( volumes I,II,III) 2000. An Open University
publication for undergraduate teaching at the third year level.
44 R.E.W. Hancock, D.N. Karunaratne and C. Egli-Bernegger. (1993). "Molecular
Organization and structural role of outer membrane macromolecules", in New
Comprehensive Biochemistry , Bacterial Cell Wall. J.-M. Ghuysen and R. Hakenbeck
(Eds). Elsevier Science B.V. (1994) Chapter 12,pp 263 -279.
45 R.E.W. Hancock and D.N. Karunaratne. "LPS integration into outer Membrane
structures", in Endotoxin Research Series, Vol. 1 A. Novotny (Ed). Elsevier Press,
Amsterdam (1990), pp 191 - 204.
RESEARCH COMMUNICATIONS
1. D.N. Karunaratne. “A new delivery agent for cancer therapeutics”. Chemistry in Sri Lanka, 2012
29,(3), 16
2. K.M.G.K. Pamunuwa, R.M.C.J. Bandara, D.N. Karunaratne and V. Karunaratne.Effect of variation
of lipid composition on properties of a liposomal delivery system. First National Nanotechnology
conference, 2012
3. E.P.N. Premarathne, D.M.R.H Dissanayake, A D L C Perera and D N Karunaratne. Investigation of
potential ability of nanoemulsion formulation for transdermal delivery of diclofenac sodium. First
National Nanotechnology conference, 2012
4. S.S.W.B.M.G.U. Ekanayake, D N Karunaratne and A D L C Perera. Formulation of liposomes
encapsulated with acetylsalicylic acid. First National Nanotechnology conference, 2012
5. M. A. S. K. Menikarachchi, D. N. Karunaratne, V. Karunaratne, V. Thevanesam & A. Ekanayake.
Chitosan based Drug-Carrier System for Controlled Release of Amoxicillin, International
Conference on Chemical Sciences Proceedings, 2012.
6. K.M.G.K. Pamunuwa, D.N. Karunaratne, V. Karunaratne. Encapsulation and slow release of the
highly antioxidant methanol extract of Schumacheria castaneifolia in liposomes. International
Conference on Chemical Sciences Proceedings, 2012.
7. A R N M Abeyrathne, A D L C Perera and D N Karunaratne. A study of liquid crystal behavior in
two novel glycosides. International Conference on Chemical Sciences Proceedings, 2012.
8. M. A. S. K. Menikarachchi, D. N. Karunaratne, & V. Karunaratne. Chitosan based Nano-Carrier
System for Controlled Release of Ascorbic Acid. Poster presented at the Global Forum of Sri Lankan
Scientists held at the Hotel Galadari, Dec 2011.
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9. A.R.N.M. Abeyrathne, A.D.L.C. Perera and D.N. Karunaratne. Synthesis of a novel glycoside to
use as a liquid crystalline material and a surfactant. Proc. of Peradeniya University Research Sessions
(PURSE), Vol. 16, 2011.
10. L.S. Hewawarawita, A.D.L.C. Perera and D.N. Karunaratne. Preparation, characterization and invitro
release study of ascorbic acid-encapsulated liquid crystal liposomes. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 16, 2011.
11. M.A.S.K. Menikarchchi, N. Karunaratne and V. Karunaratne. Chitosan based nano-carrier system
for controlled release of ascorbic acid. Proc. of Peradeniya University Research Sessions (PURSE),
Vol. 16, 2011.
12. R.M.C.J. Bandara, D.M.B. Abeykoon, R.M.R. Bandara, A. Wickramasinghe, D.S.A.
Wijesundara, N. Karunaratne and V. Karunaratne. Antioxidant, cytotoxic and phytotoxic
activities of schumacheria castaneifolia, a plant endemic to Sri Lanka. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 16, 2011.
13. R.M.D.R. Jayarathna, A.D.L.C. Perera and D.N. Karunaratne. A preliminary study on the
use of carbohydrate liquid crystals as emulsifiers in cosmetic chemistry. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 16, 2011.
14. K.M.D Gunathileke, R.R. Ratnayake, S.A. Kulasooriya and D.N. Karunaratne.
Biodegradation of Cellulose for Biofuel Production using Microbial Biofilms.
NPAHA(Natural Products Applications for Health and Agriculture), Int. Symposium, Natural
Products, IFS, Kandy, Sri Lanka 2011.
15. R.M.C.J. Bandara, A. Wickramasinghe., B.M.R. Bandara, D.N. Karunaratne, D.S.A.
Wijesundara, N.L.V.V. Karunaratne. Chemistry and Bioactivity of Schumacheria
castaneifolia A Plant Endemic to Sri Lanka, NPAHA(Natural Products Applications for
Health and Agriculture), Int. Symposium, Natural Products, IFS, Kandy, Sri Lanka. 2011.
16. L.L.W.C Yalegama, N. Karunaratne, R. Sivakanesan and C. Jayasekara. Composition and
metal binding capacity of cell wall polysaccharides extracted from coconut residue. 3 rd
Symposium on Plantation Crop Research. 2010.
17. H.A.I.R. Perera, C.G. Gunasekara, V.N.Seneviratne and D.N.Karunaratne. Understanding
the stability and the releasing properties of the molecules chelated within calcium
montmorillonite nanocomposites. Proc. of Peradeniya University Research Sessions
(PURSE), Vol. 15, 2010.
18. A. R. N. M. Abeyrathne, A. D. L. C. Perera and D. N. Karunaratne. Mesophase behaviour
of a novel sugar based liquid crystal. Proc. of Peradeniya University Research Sessions
(PURSE), Vol. 15, 2010.
19. A. R. N. M. Abeyrathne, A. D. L. C. Perera and D. N. Karunaratne. Lyotropic Liquid
crystal behaviour of two novel glycosides. 66 th Proc. of Sri Lanka Association for the
Advancement of Science (SLAAS), 2010.
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20. K. Bombuwela, S. Kathirgamanathar, U. G. W. P. Kumara, D. N. Karunaratne, K. B.
Ranawana, V. Kumar, A. Weerasooriya, A. Wijesekara, S. Wijesundara, P. Wolseley and V.
Karunaratne. The Butterfly Talicada nyseus Collects Phenolic Substances by Scraping the
Lichen Leproloma sipmanianum. Proc. Of the International Symposium on Natural Products
2010. Peradeniya, Sri Lanka.
21. A.R.N.M. Abeyrathne, A.D.L.C. Perera and D.N. Karunaratne. Surfactant and liquid
crystalline behavior of 4-chloro-3,5dimethylphenyl 2,3,4,6-tetra-O-acetyl--D-glucopyrano -
side. 65 th Proc.of Sri Lanka Association for the Advancement of Science (SLAAS), 2009.
22. W.M.U.K.Wanninayake, V.N.Seneviratne, D.N.Karunaratne and A. D. L C. Perera. Liquid
crystal behavior of an ethyl hexanoyl glucofuranose derivative. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 14, 2009.
23. Damith Perera, Rukmal Ratnayake, D.N Karunaratne, B.M. Ratnayake Bandara, D. S. A.
Wijesundara and Veranja Karunaratne. Hortonia angustifolia does not contain DPPH
sensitive antioxidant alkaloids. Proc. of Peradeniya University Research Sessions (PURSE),
Vol. 14, 2009.
24. A R N M Abeyrathne, A D L C Perera and D N Karunaratne. Surfactant behavior of two
novel glycosides: determination of critical micelle concentration by UV-visible
spectrophotometry. Proc. of Peradeniya University Research Sessions (PURSE), Vol. 14,
2009.
25. R.M.C.K. Rathnayake and D. N. Karunaratne. Evolution of organic chemistry in Sri
Lankan schools with special reference to advanced level syllabus. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 14, 2009.
26. A.R.N.M. Abeyrathne, A.D.L.C. Perera and D.N. Karunaratne. “Reaction of D-Glucose
with Cinnamyl alcohol- liquid crystal behaviour of products”. Proc. of Peradeniya University
Research Sessions (PURSE), Vol. 13, 2008.
27. S. Puvanendran, T. Manoranjan, A. Wickramasinghe, D. N. Karunaratne, V. Kumar, D. S.
A. Wijesundara and V. Karunaratne, “Alkaloids from Xylopia parvifolia and X.nigricans
(Annonaceae)”. Proc. of Peradeniya University Research Sessions (PURSE), Vol. 13, 2008.
28. A.R.N.M. Abeyrathne, A.D.L.C. Perera and D.N. Karunaratne . “Liquid Crystal (LC)
behavior of cinnamyl 2,3,4,6-tetra-O-acetyl--D-glucopyranoside”. 64 th Proc. of Sri Lanka
Association for the Advancement of Science (SLAAS), 2008.
29. K. Somaratne, A.D.L.C. Perera and D.N. Karunaratne. “Synthesis of Glucopyranoside
Carbohydrate Derived Liquid Crystal”. 64 th Proc. of Sri Lanka Association for the
Advancement of Science (SLAAS), 2008.
30. S. Puvanendran, A. Wickramasinghe, D. N. Karunaratne, D. S. A. Wijesundara and V.
Karunaratne, “Antifungal and antioxidant properties of alkaloids from Xylopia championii
(Annonaceae)”, 63 rd Proc. of Sri Lanka Association for the Advancement of Science
(SLAAS), 2007.
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31. S. Puvanendran, A. Wickramasinghe, D. N. Karunaratne, D. S. A. Wijesundara and V.
Karunaratne, “Screening of radical scavenging activity of some endemic Annonaceae plant
extracts”, Proc. of Peradeniya University Research Sessions (PURSE), Vol. 12, 2007.
32. N.B. Jayaratne, D.N. Karunaratne and N.S. Kumar. “Effect of caffeine and epigallocatechin
gallate (egcg) on sporulation, spore germination and mycelial growth of monacrosporium a.
mbrosium, ectosymbiote of the shot-hole borer beetle of tea”.
Peradeniya University Research Sessions (PURSE) Vol. 12, 2007, Peradeniya, Sri Lanka
33. G.L.A.D. Liyanage, A.D.L.C. Perera and D.N. Karunaratne. “Preliminary investigation of
the liquid crystal behaviour of -sitosteryl--D-glucopyranoside”. Proc. of Peradeniya
University Research Sessions (PURSE), Vol. 12, 2007.
34. L.S. Widanapathirana, A.D.L.C. Perera and D.N. Karunaratne . “Attempted synthesis of a
Glucofuranose Derived Carbohydrate Liquid Crystal”. Proc. of Peradeniya University
Research Sessions (PURSE), Vol. 12, 2007.
35. L.S. Widanapathirana, G.L.A.D. Liyanage, D.N. Karunaratne and A.D.L.C. Perera .
“Synthesis and Characterization of two carbohydrate derived Liquid Crystals”. National
Conference on Advanced Materials for Emerging Technologies 2007, Peradeniya, Sri Lanka.
36. N.B. Jayaratne, D.N. Karunaratne and N.S. Kumar. Effect of caffeine and epigallocatechin
gallate (EGCG) on Monacrosporium ambrosium symbiote of the shot hole borer beetle of
tea”. Peradeniya University Research Sessions 2006, Peradeniya, Sri Lanka.
37. D.N. Karunaratne and K.L. Audus. “Fluorescent compounds as functional indicators of the
efflux transporters P-glycoprotein and MRP1 in BeWo cells”. Peradeniya University
Research Sessions 2005, Peradeniya, Sri Lanka.
38. D.N. Karunaratne and K.L. Audus. “Assessing the functionality of efflux transporters P-
glycoprotein and MRP1 in BeWo cells with fluorescent substrates”.
2nd Annual Kansas City Life Sciences Research Day, 2003. Kansas City, MO, USA.
39. D.N. Karunaratne. “The role of lipopolysaccharide of some Salmonella strains in sensitivity
to defensins”. 29th Annual Sessions of the Institute of Chemistry, Ceylon, Colombo, Sri
Lanka. Chemistry in Sri Lanka, 2000 17,(3), 45.
40. D.N. Karunaratne, S. Farmer and R.E.W. Hancock. “Design, Synthesis and activity of
cyclodextrin linked lactamase inhibitors”. Abstracts of the AFPC (Association of
Faculties of Pharmacy of Canada)
Pharmaceutical Biotechnology Conference, 1993. Vancouver, Canada.
41. G.G.S. Dutton, D.N. Karunaratne, N.S. Kumar, P.A.J. Perera and U.A.K. Wickramasinghe.
“Preliminary investigation into the structure of the capsular K antigen from E. coli K 45”.
43 rd Proc. of Sri Lanka Association for the Advancement of Science (SLAAS), 1987.
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42. D.N. Karunaratne, P.A.J. Perera and U.A.K. Wickramasinghe. (1987). Development of a
medium to increase the the yield of capsular polysaccharide produced by E. coli.
Abstracts of the 43rd Annual Sessions of the Sri Lanka Association for the Advancement of
Science, Colombo, Sri Lanka.
43. G.G.S. Dutton, D.N. Karunaratne, and A.V.S. Lim. (1984).Capsular polysaccharide of
Klebsiella: New structural patterns. Abstracts of the XIIth International Carbohydrate
Symposium, Utrecht, The Netherlands.
44. G.G.S. Dutton, and D.N. Karunaratne. (1984). Bacteriophage depolymerization as an aid in
locating O-acetyl groups. Abstracts of the XIIth International Carbohydrate Symposium,
Utrecht, The Netherlands.
45. E. Altman, Dutton, G.G.S. and D.N. Karunaratne, (1983). Unique structural patterns in the
capsular polysaccharides from Klebsiella. Abstracts of papers of the American Chemical
Society. 185 (3) 51
46. G.G.S. Dutton, and D.N. Karunaratne. (1982). Structure of the capsular polysaccharide
from Klebsiella K 67. Abstracts of the XIth International Carbohydrate Symposium,
Vancouver, Canada.
47. G.G.S. Dutton, J. Di Fabio, D.N. Karunaratne, D. Leek and E.H. Merrifield. (1981).
Virology - A technique for obtaining oligosaccharides. Abstracts of the 64th Canadian
Chemical Conference, Halifax, Canada.
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