Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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Diagnostic Assays for vWD II ! Ristocetin-induced agglutination assay Platelet aggregation assay Patient PRP + graded ristocetin concentrations ! Cryoprecipitate-induced agglutination assay Patient PRP + normal cryoprecipitate Spontaneous agglutination with platelet-type pseudo-vWD ! vWF multimer analysis Gel electrophoresis Subtypes show different migration patterns Used to subtype vWD after Dx established Laborious and expensive
vWF Multimers Large Multimers Intermediate Multimers Small Multimers Normal Type I Type IIA Type IIB Type III
Page 1 and 2: Case Studies in Clinical Hemostasis
Page 3 and 4: Patient J.M. ! Middle-aged man admi
Page 5 and 6: Primary & Secondary Hemostasis Prim
Page 7 and 8: Damaged Damaged Vessel Vessel Wall
Page 9 and 10: GPIb GPIIbIIIa PLT Function Platele
Page 11 and 12: Platelet Agonists Membrane Glycopro
Page 13 and 14: Platelet Aggregation Light Shape Ch
Page 15 and 16: Coagulation Prothrombin Thrombin Fi
Page 17 and 18: Contact Factors - Charged Surface M
Page 19 and 20: Prothrombin Time (PT) Thromboplasti
Page 21 and 22: Activated Partial Thromboplastin Ti
Page 23 and 24: Defects of Hemostasis Bleeding Thro
Page 25 and 26: Platelet Diseases Bleeding Thrombos
Page 27 and 28: Factor Activity (%) 200 180 160 140
Page 29 and 30: GPIb GPIIbIIIa vWD Platelet membran
Page 31 and 32: History of vWD ! 1926 - Erik Adolf
Page 33 and 34: Clinical Features of vWD Epistaxis
Page 35 and 36: von Willebrand’s Disease Classifi
Page 37: Diagnostic Assays for vWD I ! Facto
Page 41: Case Studies in Clinical Hemostasis

Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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