Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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von Willebrand’s Disease Laboratory Features ! Normal PLT (with exceptions) ! Prolonged bleeding time ! Prolonged aPTT ! Decreased factor VIII activity (FVIII:C) ! Decreased vWF antigen (vWF:Ag) ! Abnormal ristocetin cofactor activity (vWF:RCoF) ! Abnormal vWF multimeric composition ! Molecular abnormalities
Diagnostic Assays for vWD I ! Factor VIII activity Clotting assay Capacity of patient plasma dilutions to correct clotting time of FVIII-deficient plasma ! vWF Activity (RCoF Activity) Platelet aggregation assa y Different concentrations of ristocetin mixed with patient PPP and normal platelets ! vWF Antigen Immunoassay quantitation ELISA commonly utiized
Page 1 and 2: Case Studies in Clinical Hemostasis
Page 3 and 4: Patient J.M. ! Middle-aged man admi
Page 5 and 6: Primary & Secondary Hemostasis Prim
Page 7 and 8: Damaged Damaged Vessel Vessel Wall
Page 9 and 10: GPIb GPIIbIIIa PLT Function Platele
Page 11 and 12: Platelet Agonists Membrane Glycopro
Page 13 and 14: Platelet Aggregation Light Shape Ch
Page 15 and 16: Coagulation Prothrombin Thrombin Fi
Page 17 and 18: Contact Factors - Charged Surface M
Page 19 and 20: Prothrombin Time (PT) Thromboplasti
Page 21 and 22: Activated Partial Thromboplastin Ti
Page 23 and 24: Defects of Hemostasis Bleeding Thro
Page 25 and 26: Platelet Diseases Bleeding Thrombos
Page 27 and 28: Factor Activity (%) 200 180 160 140
Page 29 and 30: GPIb GPIIbIIIa vWD Platelet membran
Page 31 and 32: History of vWD ! 1926 - Erik Adolf
Page 33 and 34: Clinical Features of vWD Epistaxis
Page 35: von Willebrand’s Disease Classifi
Page 39 and 40: vWF Multimers Large Multimers Inter
Page 41: Case Studies in Clinical Hemostasis

Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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