Case Studies in Clinical Hemostasis Case Studies in ... - Pathology
Case Studies in Clinical Hemostasis Case Studies in ... - Pathology
Case Studies in Clinical Hemostasis Case Studies in ... - Pathology
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von Willebrand’s Disease<br />
Classification<br />
! Type 1 - 70-80%, mild, autosomal recessive<br />
! Type 2<br />
Type 2A - 15-20%, mild<br />
Type 2N - Rare, moderate, failure of vWF to<br />
complex with VIII:C<br />
Type 2B - Rare, thrombocytopenia,<br />
<strong>in</strong>creased vWF aff<strong>in</strong>ity for PLTS<br />
! Type 3 - Very rare, severe, decreased vWF and<br />
factor VIII, autosomal recessive<br />
! Platelet-Type Pseudo vWF - Abnormality of PLT<br />
GP1b receptor, <strong>in</strong>creased vWF aff<strong>in</strong>ity,<br />
resembles Type 2B<br />
! Acquired vWF - Usually autoimmune etiology