Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

von Willebrand’s Disease
Classification
! Type 1 - 70-80%, mild, autosomal recessive
! Type 2
Type 2A - 15-20%, mild
Type 2N - Rare, moderate, failure of vWF to
complex with VIII:C
Type 2B - Rare, thrombocytopenia,
increased vWF affinity for PLTS
! Type 3 - Very rare, severe, decreased vWF and
factor VIII, autosomal recessive
! Platelet-Type Pseudo vWF - Abnormality of PLT
GP1b receptor, increased vWF affinity,
resembles Type 2B
! Acquired vWF - Usually autoimmune etiology