Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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Relationship Between vWF and ABO Blood Groups Individuals with Blood Group O have significantly lower levels of vWF than those with blood groups A, B, or AB
von Willebrand’s Disease Classification ! Type 1 - 70-80%, mild, autosomal recessive ! Type 2 Type 2A - 15-20%, mild Type 2N - Rare, moderate, failure of vWF to complex with VIII:C Type 2B - Rare, thrombocytopenia, increased vWF affinity for PLTS ! Type 3 - Very rare, severe, decreased vWF and factor VIII, autosomal recessive ! Platelet-Type Pseudo vWF - Abnormality of PLT GP1b receptor, increased vWF affinity, resembles Type 2B ! Acquired vWF - Usually autoimmune etiology
Page 1 and 2: Case Studies in Clinical Hemostasis
Page 3 and 4: Patient J.M. ! Middle-aged man admi
Page 5 and 6: Primary & Secondary Hemostasis Prim
Page 7 and 8: Damaged Damaged Vessel Vessel Wall
Page 9 and 10: GPIb GPIIbIIIa PLT Function Platele
Page 11 and 12: Platelet Agonists Membrane Glycopro
Page 13 and 14: Platelet Aggregation Light Shape Ch
Page 15 and 16: Coagulation Prothrombin Thrombin Fi
Page 17 and 18: Contact Factors - Charged Surface M
Page 19 and 20: Prothrombin Time (PT) Thromboplasti
Page 21 and 22: Activated Partial Thromboplastin Ti
Page 23 and 24: Defects of Hemostasis Bleeding Thro
Page 25 and 26: Platelet Diseases Bleeding Thrombos
Page 27 and 28: Factor Activity (%) 200 180 160 140
Page 29 and 30: GPIb GPIIbIIIa vWD Platelet membran
Page 31 and 32: History of vWD ! 1926 - Erik Adolf
Page 33: Clinical Features of vWD Epistaxis
Page 37 and 38: Diagnostic Assays for vWD I ! Facto
Page 39 and 40: vWF Multimers Large Multimers Inter
Page 41: Case Studies in Clinical Hemostasis

Case Studies in Clinical Hemostasis Case Studies in ... - Pathology

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