DOS BULLETIN - Dansk Ortopædisk Selskab

2010-378_DOS nr. 3 2010 29/09/10 10:08 Side 99
Predicting mortality in hip fracture patients
using routine blood tests
Mathias Mosfeldt, Ole B. Pedersen, Troels Riis, Henrik L. Jørgensen,
Benn R. Duus, Jes B. Lauritzen
Department of Orthopedics, Bispebjerg University Hopital;
Department of Clinical Immunology - Tissue Typing Laboratory,
Rigshospitalet; Deparment of Clinical Biochemistry,
Bispebjerg University Hospital
Background: Hip fractures are associated with excess mortality, and
several studies have pointed out the burden on society health care costs
and the need to optimize cost effectiveness in treatment.
Purpose: The goal of our study was to investigate if patients with a higher
risk of death after hip fracture could be identified using routine blood
tests taken on admission.
Methods: All hip fracture patients admitted to the Department of Orthopedics,
Bispebjerg University Hospital from October 2008 till December
2009 were included prospectively. We only included patients that had
project blood samples taken at the day of admission resulting in 324 hip
fracture patients for further analysis. Follow up data on mortality were
obtained from the civil registration system the first of February 2010.
Predictors for mortality were determined by logistic and cox regression
models. P < 0.05 was regarded as statistically significant.
Findings: Of the 324 hip fracture patients under study, 66 (20%) died
within the study period. The results of stepwise Cox multivariate regression
models for survival during the first three months after admission
revealed that plasma creatinine, albumin and age predict mortality. The
hazard ratios were 1.04 (95% CI: 1.005-1.09, p=0.02), 1.01 (per unit
increase)(95% CI: 1.01-1.02, p