02 BOOK OF ABSTRACTS .indd

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The Cancer Degradome: new insights into protease function in cancer biology Dylan R. Edwards School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK There is a long history that implicates secreted proteases such as the matrix metalloproteinases and the serine proteases of the plasminogen activation cascade as mediators of the genesis and spread of cancer. However, synthetic MP inhibitors proved disappointing in clinical trials and there is a growing awareness that proteases can in some instances antagonize rather than promote tumourigenesis. It is therefore necessary to unravel the contributions of components of the “degradome” – the repertoire of proteases, substrates and inhibitors employed in malignant tumours. Knowledge of the cancer degradome may lead to new diagnostic markers and therapeutic agents, and also to improved imaging of tumours. The talk will review recent progress from bioinformatic analysis of the degradome, and expression profiling and functional studies concerning the involvement of proteases in breast and prostate cancer. In particular, our data have identified MMP8 and ADAMTS15 as novel markers of good prognosis in breast cancer, whereas MMP11 and ADAMTS8 are associated with poor outcome. The rationale for the design of novel, selective agents that target proteolysis will also be highlighted. 20l7
Differential effects of Cathepsin L deficiency on multistage tumorigenesis of epidermal carcinomas in K14-HPV16 mice as compared to islet cell tumors in the RIP1-Tag2 mouse tumor model Thomas Reinheckel 1 , Tobias Lohmüller 1 , Vasilena Gocheva 2 , Julia Dennemärker 1 , Christoph Peters 1 , and Johanna A. Joyce 2 1 Department of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Germany; 2 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10<strong>02</strong>1, USA. To assess the functional significance of cathepsin L (CTSL) in epidermal carcinogenesis, we adopted a genetic approach utilizing ctsl -/- mice bred with transgenic Tg(K14-HPV16) mice, which express the human papillomavirus type 16 oncogenes under the control of the keratin 14 promoter and reproducibly show multistage development of invasive squamous cell carcinomas of the epidermis. During the observation period of 52 weeks the overall survival of Tg(K14-HPV16);ctsl -/- mice is significantly shorter than the survival of Tg(K14-HPV16);ctsl +/+ ,and Tg(K14-HPV16);ctsl +/- mice. Development of dysplastic lesions and average tumor onset of Tg(K14-HPV16);ctsl - /- mice occurs 2 months earlier than in Tg(K14-HPV16);ctsl +/+ or Tg(K14-HPV16);ctsl +/- mice (p
Page 2 and 3: Co-chairs of the conference: Scient
Page 4 and 5: Contents Conference programme 5 Lis
Page 6 and 7: Differential effects of Cathepsin L
Page 8 and 9: 17.25 - 17.50 Golzio Muriel, IPBS C
Page 10 and 11: List of lectures: L1. Teissiè Just
Page 13 and 14: Abstracts of lectures 13
Page 15 and 16: Proteases and their inhibitors duri
Page 17 and 18: Biochemical characterization and cl
Page 19: Assessment of cathepsin B activity
Page 23 and 24: anecdotally and within a clinical t
Page 25 and 26: Tumor cell- and macrophage-derived
Page 27 and 28: The selection of serological marker
Page 29 and 30: Cathepsins and their inhibitors in
Page 31 and 32: Matrix metalloproteinase expression
Page 33 and 34: l18 33 Complement resistance impair
Page 35 and 36: Classical tumor vaccine potently st
Page 37 and 38: CpG oligonucleotides admixed with i
Page 39 and 40: Electrochemotherapy in veterinary o
Page 41 and 42: studies were able to provide a deta
Page 43 and 44: threshold and electric field intens
Page 45 and 46: Gene delivery systems in cancer gen
Page 47 and 48: Electropermeabilization: a non vira
Page 49 and 50: Visible light microscopy, efficient
Page 51 and 52: Progress in tumour vascular targeti
Page 53 and 54: The Fer kinas: a novel target for p
Page 55 and 56: Targeting of plasminogen activation
Page 57 and 58: Functional interdependence of natur
Page 59 and 60: Antiprotease therapy in cancer: hot
Page 61 and 62: Functional genomics and systems bio
Page 63 and 64: Tumor proteolysis: a multidimension
Page 65 and 66: Stem cell therapy for liver insuffi
Page 67 and 68: Increased plasma DNA concentration
Page 69 and 70: List of poster presentations P1. Ab
Page 71 and 72:
Abstracts of posters 71
Page 73 and 74:
Tumor VEGF modulates host proteolyt
Page 75 and 76:
New inhibitors of human hydroxyster
Page 77 and 78:
Cytotoxicity and antitumour effecti
Page 79 and 80:
Quantification of lysosomal fusion
Page 81 and 82:
Spatiotemporal relevance of tumor c
Page 83 and 84:
Electrogene therapy with p53 alone
Page 85 and 86:
Do organophosphorous pesticides pla
Page 87 and 88:
Molecular analysis of lymphoprolife
Page 89 and 90:
Humoral response in pleural space t
Page 91 and 92:
In conclusion, this study shows tha
Page 93 and 94:
Angiogenesis correlates with cycloo
Page 95 and 96:
Inhibition of mouse uPA activity by
Page 97 and 98:
Cathepsin X interacts with integrin
Page 99 and 100:
Annexin-V apoptosis analysis of hum
Page 101 and 102:
Tissue swelling at the site of elec
Page 103 and 104:
p30103 The Bcl-2 family members: me
Page 105 and 106:
p32105 Proteomics of astrocytic neo
Page 107 and 108:
Correlation of chromosomal abnormal
Page 109 and 110:
Optimization of treatment parameter
Page 111 and 112:
The effect of xantohumol on normal
Page 113 and 114:
Cappabianca Lucia University of Aqu
Page 115 and 116:
Jevnikar Zala University of Ljublja
Page 117 and 118:
Mesojednik Suzana Institute of Onco
Page 119 and 120:
Rols Marie-Pierre Institute of Phar
Page 121 and 122:
Author Index Abramovi} Zrinka 72 Ak
Page 123 and 124:
Paridaens R. 31 Parker Katharine 99
Page 125 and 126:
125
Page 127 and 128:
127
Page 129 and 130:
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Page 131 and 132:
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