MOM 2006 journal for pdf.pmd - University of Michigan-Flint

As seen from the distance data above, it is possible that there is a collation between the
backbone of the structure and the distance between the rings. The structures that had similar ring
distances to paclitaxel were either analog 28 or 29 therefore, seems to be a preference for the 6-8-
6 backbone to achieve a similar ring distance.
By comparison of 28-NH-CH 2
-RRR and 29-NH-CH 2
-RRR from above it could be concluded
that the additional methyl group on 29 makes no difference in determining the distance between
the methyl groups. 28-NH-CH 2
-RRR has a distance of 10.87Å and 29-NH-CH 2
-RRR has a
distance of 10.77Å. Therefore, the additional methyl group is not necessary for the molecule to
have a similar ring distance.
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